Charge transport properties of SARS-CoV-2 Delta variant (B.1.617.2).

Lijun He, Zhiyang Xie, Xing Long, Chaopeng Zhang, Chengyun He, Boyang Zhao, Fei Qi, Nan Zhang
Author Information
  1. Lijun He: The School of Optoelectronic Engineering, Chongqing University of Posts and Telecommunications, Chongqing 400065, China.
  2. Zhiyang Xie: The School of Optoelectronic Engineering, Chongqing University of Posts and Telecommunications, Chongqing 400065, China.
  3. Xing Long: The School of Optoelectronic Engineering, Chongqing University of Posts and Telecommunications, Chongqing 400065, China.
  4. Chaopeng Zhang: The School of Optoelectronic Engineering, Chongqing University of Posts and Telecommunications, Chongqing 400065, China.
  5. Chengyun He: The School of Optoelectronic Engineering, Chongqing University of Posts and Telecommunications, Chongqing 400065, China.
  6. Boyang Zhao: The School of Optoelectronic Engineering, Chongqing University of Posts and Telecommunications, Chongqing 400065, China.
  7. Fei Qi: The School of Optoelectronic Engineering, Chongqing University of Posts and Telecommunications, Chongqing 400065, China.
  8. Nan Zhang: The School of Optoelectronic Engineering, Chongqing University of Posts and Telecommunications, Chongqing 400065, China.

Abstract

The B.1.617.2 (Delta) variant of concern is causing a new wave of infections in many countries. In order to better understand the changes of the SARS-CoV-2 mutation at the genetic level, we selected six mutations in the S region of the Delta variant compared with the native SARS-CoV-2 and get the conductance information of these six short RNA oligonucleotides groups by construct RNA: DNA hybrids. The electronic characteristics are investigated by the combination of density functional theory and non-equilibrium Green's function formulation with decoherence. We found that conductance is very sensitive to small changes in virus sequence. Among the 6 mutations in the Delta S region, D950N shows the largest change in relative conductance, reaching a surprising 4104.75%. These results provide new insights into the Delta variant from the perspective of its electrical properties. This may be a new method to distinguish virus variation and possess great research prospects.

Keywords

References

  1. Science. 2020 Mar 13;367(6483):1260-1263 [PMID: 32075877]
  2. Mol Cell Biochem. 2021 Mar;476(3):1599-1603 [PMID: 33405086]
  3. J Comput Chem. 2012 Feb 15;33(5):580-92 [PMID: 22162017]
  4. Hum Vaccin Immunother. 2021 Nov 2;17(11):4126-4127 [PMID: 34473593]
  5. Genomics Proteomics Bioinformatics. 2020 Dec;18(6):749-759 [PMID: 33704069]
  6. ACS Appl Mater Interfaces. 2021 Dec 15;13(49):59154-59163 [PMID: 34856097]
  7. J Phys Chem Lett. 2016 May 19;7(10):1888-94 [PMID: 27145167]
  8. Phys Rev Lett. 1987 May 4;58(18):1861-1864 [PMID: 10034557]
  9. Zool Res. 2020 Nov 18;41(6):705-708 [PMID: 33045776]
  10. Yi Chuan. 2020 Feb 20;42(2):212-221 [PMID: 32102777]
  11. Cell. 2020 Apr 16;181(2):281-292.e6 [PMID: 32155444]
  12. Biopolymers. 2021 Aug;112(8):e23465 [PMID: 34242395]
  13. Science. 2021 Dec 24;374(6575):1621-1626 [PMID: 34751595]
  14. Nat Nanotechnol. 2018 Dec;13(12):1167-1173 [PMID: 30397286]

Word Cloud

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