Association of self-reported snoring with decreased retinal thickness and vessel density.
Yunfan Xiao, Keai Shi, Chunmei Li, Kai Yang, Xiaoxuan Zhu, Binbin Su, Ying Ju, Fan Lu, Jia Qu, Ming Li, Lele Cui
Author Information
Yunfan Xiao: Eye Hospital and School of Ophthalmology and Optometry, National Clinical Research Center for Ocular Diseases, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Keai Shi: Eye Hospital and School of Ophthalmology and Optometry, National Clinical Research Center for Ocular Diseases, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Chunmei Li: Eye Hospital and School of Ophthalmology and Optometry, National Clinical Research Center for Ocular Diseases, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Kai Yang: Eye Hospital and School of Ophthalmology and Optometry, National Clinical Research Center for Ocular Diseases, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Xiaoxuan Zhu: Eye Hospital and School of Ophthalmology and Optometry, National Clinical Research Center for Ocular Diseases, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Binbin Su: Eye Hospital and School of Ophthalmology and Optometry, National Clinical Research Center for Ocular Diseases, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Ying Ju: Eye Hospital and School of Ophthalmology and Optometry, National Clinical Research Center for Ocular Diseases, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Fan Lu: Eye Hospital and School of Ophthalmology and Optometry, National Clinical Research Center for Ocular Diseases, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Jia Qu: Eye Hospital and School of Ophthalmology and Optometry, National Clinical Research Center for Ocular Diseases, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Ming Li: Eye Hospital and School of Ophthalmology and Optometry, National Clinical Research Center for Ocular Diseases, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Lele Cui: Eye Hospital and School of Ophthalmology and Optometry, National Clinical Research Center for Ocular Diseases, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Self-reported snoring has been reported to influence nerves and vessels. However, there are few direct evidences of snoring related to nerves and microvessels defects. Therefore, we evaluated the association of self-reported snoring with retinal structure and microcirculation. A total of 2,622 participants were recruited from the Jidong eye cohort study (JECS). Physical examinations, laboratory tests, and questionnaires were recorded. We also used optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) to assess the retinal structure and microvascular network. Snoring was defined as "never," "occasionally," and "frequently or more severe" according to self-reported frequency. The prevalence of snoring were 84.6% ( = 983) and 45.0% ( = 657) in males and females, respectively. Compared with never snoring group, the retinal thickness increased in "occasionally" ( < 0.001) and "frequently or more severe" groups ( = 0.001), while no difference was found between snoring groups ( = 0.14). Superficial retinal capillary plexus (RCP) vessel density was lower in "frequently or more severe" group than in "never" ( < 0.001) and "occasionally" snoring groups ( < 0.001). After adjusting for confounders, "frequently or more severe" snoring was significantly associated with thinner total retinal thickness [ = -2.79 (95% CI: -5.27, -0.30)] and lower superficial RCP vessel density [ = -0.71 (95% CI: -1.19, -0.23)]. Our research showed self-reported snoring was associated with thinner retinal thickness and lower superficial RCP vessel density. The findings of our study emphasize the need for self-reported snoring assessments in determining retinal structure and microcirculation impairment.
