Platelet function changes in patients undergoing endovascular aortic aneurysm repair: Review of the literature.
Anna Burban, Aleksandra Idzik, Agata Gelo, Krzysztof J Filipiak, Tomasz Jakimowicz, Katarzyna Jama, Marcin Grabowski, Aleksandra Gasecka, Aleksander Siniarski
Author Information
Anna Burban: Chair and Department of Cardiology, Medical University of Warsaw, Warsaw, Poland.
Aleksandra Idzik: Chair and Department of Cardiology, Medical University of Warsaw, Warsaw, Poland.
Agata Gelo: Department of Anesthesiology and Intensive Care, Medical University of Warsaw, Warsaw, Poland.
Krzysztof J Filipiak: Department of Clinical Sciences, Maria Sklodowska-Curie Medical Academy, Warsaw, Poland.
Tomasz Jakimowicz: Department of General, Vascular and Transplant Surgery, Medical University of Warsaw, Warsaw, Poland.
Katarzyna Jama: Department of General, Vascular and Transplant Surgery, Medical University of Warsaw, Warsaw, Poland.
Marcin Grabowski: Chair and Department of Cardiology, Medical University of Warsaw, Warsaw, Poland.
Aleksandra Gasecka: Chair and Department of Cardiology, Medical University of Warsaw, Warsaw, Poland.
Aleksander Siniarski: Department of Coronary Disease and Heart Failure, Institute of Cardiology, Jagiellonian University Medical College, Cracow, Poland.
Patients with abdominal aortic aneurysm (AAA) have a higher risk of cardiovascular (CV) events, which seems to be associated with disturbed platelet (PLT) function. Endovascular aneurysm repair (EVAR) is an emerging, less-invasive treatment alternative to surgical AAA repair. Both platelet function abnormalities in patients with AAA and the effect of EVAR on platelet function are poorly understood. In this review, we aim to fill the gap regarding the effect of EVAR on PLT function in AAA patients by discussing PLT function disturbances in patients with AAA, PLT function changes after EVAR, evidence from clinical studies regarding PLT function before and after EVAR, and antiplatelet or and antithrombotic treatment in patients undergoing EVAR. The goal of our review is to summarize the contemporary knowledge and initiate further studies to better understand PLT function changes in patients undergoing EVAR, optimize the pharmacotherapy before and after EVAR and further improve outcomes in this group of patients.
