Globally, phenolic contaminants have posed a considerable threat to agro-ecosystems. Exolaccase-boosted humification may be an admirable strategy for phenolic detoxification by creating multifunctional humic-like products (H-LPs). Nonetheless, the potential applicability of the formed H-LPs in agricultural production is still overlooked. This review describes immobilized exolaccase-enabled humification in eliminating phenolic pollutants and producing artificial H-LPs. The similarities and differences between artificial H-LPs and natural humic substances (HSs) in chemical properties are compared. In particular, the agronomic effects of these reproducible artificial H-LPs are highlighted. On the basis of the above summary, the granulation process is employed to prepare granular humic-like organic fertilizers, which can be applied to field crops by mechanical side-deep fertilization. Finally, the challenges and perspectives of exolaccase-boosted humification for practical applications are also discussed. This review is a first step toward a more profound understanding of phenolic detoxification, soil improvement, and agricultural production by exolaccase-boosted humification.
