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PloS one
2022;17 (8): e0272954.

Genomic characterization of SARS-CoV-2 from vaccine breakthrough cases in Allegheny County, Pennsylvania.

Kady D Waggle, Marissa P Griffith, Lei Zhu, Vaughn S Cooper, Daniel J Snyder, Vatsala Srinivasa, Tung Phan, Alan Wells, Graham M Snyder, Daria Van Tyne, Lee H Harrison, Jane W Marsh
Author Information
  1. Kady D Waggle: Microbial Genomics Epidemiology Laboratory, Center for Genomic Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
  2. Marissa P Griffith: Microbial Genomics Epidemiology Laboratory, Center for Genomic Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
  3. Lei Zhu: Microbial Genomics Epidemiology Laboratory, Center for Genomic Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
  4. Vaughn S Cooper: Department of Microbiology and Molecular Genetics and Center for Evolutionary Biology and Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America. ORCID
  5. Daniel J Snyder: Microbial Genome Sequencing Center, LLC, Pittsburgh, Pennsylvania, United States of America.
  6. Vatsala Srinivasa: Microbial Genomics Epidemiology Laboratory, Center for Genomic Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
  7. Tung Phan: Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
  8. Alan Wells: Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
  9. Graham M Snyder: Department of Infection Control and Hospital Epidemiology, UPMC Presbyterian, Pittsburgh, Pennsylvania, United States of America. ORCID
  10. Daria Van Tyne: Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.
  11. Lee H Harrison: Microbial Genomics Epidemiology Laboratory, Center for Genomic Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
  12. Jane W Marsh: Microbial Genomics Epidemiology Laboratory, Center for Genomic Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America. ORCID
PMID: 36044529 DOI: 10.1371/journal.pone.0272954

Abstract

We performed whole genome sequencing on SARS-CoV-2 from 59 vaccinated individuals from southwest Pennsylvania who tested positive between February and September, 2021. A comparison of mutations among vaccine breakthrough cases to a time-matched control group identified potential adaptive responses of SARS-CoV-2 to vaccination.

References

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MeSH Term

Antibodies, Viral
COVID-19
Genomics
Humans
Pennsylvania
SARS-CoV-2
Viral Vaccines

Chemicals

Antibodies, Viral
Viral Vaccines
Journal Article Research Support, Non-U.S. Gov't
Article has an altmetric score of 1

Word Cloud

Created with Highcharts 10.0.0SARS-CoV-2Pennsylvaniavaccinebreakthroughcasesperformedwholegenomesequencing59vaccinatedindividualssouthwesttestedpositiveFebruarySeptember2021comparisonmutationsamongtime-matchedcontrolgroupidentifiedpotentialadaptiveresponsesvaccinationGenomiccharacterizationAlleghenyCounty

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