OpenLB
Open Library of Bioscience
Advanced Search
Cells
09 04, 2022;11 (17):

Lung Organoids as Model to Study SARS-CoV-2 Infection.

Li Peng, Li Gao, Xinya Wu, Yuxin Fan, Meixiao Liu, Jingjing Chen, Jieqin Song, Jing Kong, Yan Dong, Bingxue Li, Aihua Liu, Fukai Bao
Author Information
  1. Li Peng: The Institute for Tropical Medicine, Faculty of Basic Medical Science, Kunming Medical University, Kunming 650500, China.
  2. Li Gao: The Institute for Tropical Medicine, Faculty of Basic Medical Science, Kunming Medical University, Kunming 650500, China.
  3. Xinya Wu: The Institute for Tropical Medicine, Faculty of Basic Medical Science, Kunming Medical University, Kunming 650500, China.
  4. Yuxin Fan: The Institute for Tropical Medicine, Faculty of Basic Medical Science, Kunming Medical University, Kunming 650500, China.
  5. Meixiao Liu: The Institute for Tropical Medicine, Faculty of Basic Medical Science, Kunming Medical University, Kunming 650500, China.
  6. Jingjing Chen: The Institute for Tropical Medicine, Faculty of Basic Medical Science, Kunming Medical University, Kunming 650500, China.
  7. Jieqin Song: The Institute for Tropical Medicine, Faculty of Basic Medical Science, Kunming Medical University, Kunming 650500, China.
  8. Jing Kong: The Institute for Tropical Medicine, Faculty of Basic Medical Science, Kunming Medical University, Kunming 650500, China.
  9. Yan Dong: The Institute for Tropical Medicine, Faculty of Basic Medical Science, Kunming Medical University, Kunming 650500, China.
  10. Bingxue Li: The Institute for Tropical Medicine, Faculty of Basic Medical Science, Kunming Medical University, Kunming 650500, China.
  11. Aihua Liu: The Institute for Tropical Medicine, Faculty of Basic Medical Science, Kunming Medical University, Kunming 650500, China.
  12. Fukai Bao: The Institute for Tropical Medicine, Faculty of Basic Medical Science, Kunming Medical University, Kunming 650500, China. ORCID
PMID: 36078166 DOI: 10.3390/cells11172758

Abstract

Coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic and has severely affected socio-economic conditions and people's life. The lung is the major target organ infected and (seriously) damaged by SARS-CoV-2, so a comprehensive understanding of the virus and the mechanism of infection are the first choices to overcome COVID-19. Recent studies have demonstrated the enormous value of human organoids as platforms for virological research, making them an ideal tool for researching host-pathogen interactions. In this study, the various existing lung organoids and their identification biomarkers and applications are summarized. At the same time, the seven coronaviruses currently capable of infecting humans are outlined. Finally, a detailed summary of existing studies on SARS-CoV-2 using lung organoids is provided and includes pathogenesis, drug development, and precision treatment. This review highlights the value of lung organoids in studying SARS-CoV-2 infection, bringing hope that research will alleviate COVID-19-associated lung infections.

Keywords

COVID-19 SARS-CoV-2 coronavirus lung organoid

References

  1. Stem Cells Transl Med. 2021 Nov;10(11):1491-1499 [PMID: 34302450]
  2. Mol Syst Biol. 2020 Jul;16(7):e9610 [PMID: 32715618]
  3. Nature. 2021 Jan;589(7841):270-275 [PMID: 33116299]
  4. J Clin Invest. 2017 Jun 1;127(6):2277-2294 [PMID: 28463226]
  5. Stem Cell Reports. 2018 Jan 9;10(1):101-119 [PMID: 29249664]
  6. Cell Stem Cell. 2020 Dec 3;27(6):905-919.e10 [PMID: 33142113]
  7. Sci Rep. 2019 Sep 17;9(1):13450 [PMID: 31530844]
  8. N Engl J Med. 2003 May 15;348(20):1953-66 [PMID: 12690092]
  9. J Am Geriatr Soc. 2020 Dec;68(12):2735-2743 [PMID: 33045106]
  10. Nature. 2021 May;593(7860):492-494 [PMID: 34040221]
  11. N Engl J Med. 2020 Aug 6;383(6):590-592 [PMID: 32402155]
  12. Microbiol Mol Biol Rev. 2005 Dec;69(4):635-64 [PMID: 16339739]
  13. Lancet. 2020 May 9;395(10235):1517-1520 [PMID: 32311318]
  14. Nat Commun. 2021 Feb 8;12(1):866 [PMID: 33558541]
  15. Thromb Haemost. 2020 Jun;120(6):998-1000 [PMID: 32316063]
  16. Elife. 2021 Jan 04;10: [PMID: 33393462]
  17. Nat Med. 2017 Jan;23(1):49-59 [PMID: 27869805]
  18. Stem Cells Int. 2020 Mar 11;2020:5847876 [PMID: 32256609]
  19. Cell Stem Cell. 2017 Oct 5;21(4):472-488.e10 [PMID: 28965766]
  20. Front Med (Lausanne). 2021 Oct 13;8:728543 [PMID: 34722569]
  21. JAMA. 2020 Apr 28;323(16):1574-1581 [PMID: 32250385]
  22. Stem Cell Reports. 2021 Mar 9;16(3):505-518 [PMID: 33636110]
  23. EMBO J. 2021 Mar 1;40(5):e105912 [PMID: 33283287]
  24. Stem Cell Reports. 2021 Mar 9;16(3):437-445 [PMID: 33631122]
  25. Wiley Interdiscip Rev Dev Biol. 2021 Nov;10(6):e399 [PMID: 33145915]
  26. Gastroenterology. 2011 Nov;141(5):1762-72 [PMID: 21889923]
  27. N Engl J Med. 2020 Jul 9;383(2):120-128 [PMID: 32437596]
  28. J Allergy Clin Immunol. 2020 Jul;146(1):110-118 [PMID: 32294485]
  29. Cell. 2020 Apr 16;181(2):281-292.e6 [PMID: 32155444]
  30. N Engl J Med. 2012 Nov 8;367(19):1814-20 [PMID: 23075143]
  31. Sci Adv. 2019 Sep 06;5(9):eaaw2459 [PMID: 31523707]
  32. Cell Stem Cell. 2020 Dec 3;27(6):890-904.e8 [PMID: 33128895]
  33. Nat Rev Cancer. 2015 Dec;15(12):701-11 [PMID: 26563462]
  34. Cell Stem Cell. 2020 Dec 3;27(6):962-973.e7 [PMID: 32979316]
  35. Nat Protoc. 2015 Mar;10(3):413-25 [PMID: 25654758]
  36. Nat Cell Biol. 2017 May;19(5):542-549 [PMID: 28436965]
  37. Nat Methods. 2022 Apr;19(4):418-428 [PMID: 35396481]
  38. Int J Mol Sci. 2021 Feb 26;22(5): [PMID: 33652988]
  39. Stem Cell Reports. 2016 Jan 12;6(1):18-25 [PMID: 26724905]
  40. Cell. 2020 Jul 23;182(2):429-446.e14 [PMID: 32526206]
  41. EMBO J. 2020 Nov 2;39(21):e106057 [PMID: 32944968]
  42. Stem Cell Res. 2021 May;53:102207 [PMID: 33677394]
  43. J Infect. 2020 Jun;80(6):656-665 [PMID: 32283155]
  44. Exp Hematol Oncol. 2018 Dec 5;7:30 [PMID: 30534474]
  45. Nature. 2013 Sep 19;501(7467):373-9 [PMID: 23995685]
  46. Nature. 2020 May;581(7807):221-224 [PMID: 32225175]
  47. Phytomedicine. 2021 May;85:153242 [PMID: 33867046]
  48. Cell Stem Cell. 2017 Jun 1;20(6):844-857.e6 [PMID: 28366587]
  49. JMIR Public Health Surveill. 2020 Jul 10;6(3):e19538 [PMID: 32589146]
  50. EMBO Mol Med. 2021 Jan 11;13(1):e12828 [PMID: 33159417]
  51. Dis Model Mech. 2019 Jul 29;12(7): [PMID: 31383635]
  52. Stem Cell Reports. 2014 Sep 9;3(3):394-403 [PMID: 25241738]
  53. Cell Discov. 2020 Mar 16;6:14 [PMID: 32194980]
  54. J Intern Med. 2020 Oct;288(4):469-476 [PMID: 32498135]
  55. Nat Biotechnol. 2005 Dec;23(12):1534-41 [PMID: 16258519]
  56. Biochem Pharmacol. 2021 Jan;183:114296 [PMID: 33191206]
  57. J Autoimmun. 2021 Nov;124:102715 [PMID: 34399188]
  58. Front Cell Infect Microbiol. 2020 Nov 25;10:587269 [PMID: 33324574]
  59. Nat Biotechnol. 2014 Jan;32(1):84-91 [PMID: 24291815]
  60. Eur Rev Med Pharmacol Sci. 2021 Dec;25(24):8012-8018 [PMID: 34982465]
  61. Clin Transl Immunology. 2020 May 05;9(5):e1131 [PMID: 32377340]
  62. EMBO J. 2021 Mar 1;40(5):e107651 [PMID: 33576058]
  63. Dev Cell. 2010 Jan 19;18(1):8-23 [PMID: 20152174]
  64. Virus Res. 2020 Sep;286:198070 [PMID: 32569708]
  65. Cell Rep. 2021 May 4;35(5):109055 [PMID: 33905739]
  66. Elife. 2016 Sep 28;5: [PMID: 27677847]
  67. mBio. 2014 Feb 25;5(2):e00884-14 [PMID: 24570370]
  68. Science. 2014 Jul 18;345(6194):1247125 [PMID: 25035496]
  69. Nat Microbiol. 2021 Jan;6(1):11-18 [PMID: 33273742]
  70. Protein Cell. 2021 Sep;12(9):717-733 [PMID: 33314005]
  71. J Cell Biol. 2017 Jan 2;216(1):31-40 [PMID: 28031422]
  72. Nat Biotechnol. 2011 Mar;29(3):267-72 [PMID: 21358635]
  73. Science. 2005 Sep 16;309(5742):1864-8 [PMID: 16166518]
  74. Cell Stem Cell. 2020 Jul 2;27(1):125-136.e7 [PMID: 32579880]
  75. Can Med Assoc J. 1946 Aug;55(2):151-2 [PMID: 20323870]
  76. Nat Med. 2004 Apr;10(4):368-73 [PMID: 15034574]
  77. J Virol. 2005 Jan;79(2):884-95 [PMID: 15613317]
  78. N Engl J Med. 2020 Sep 3;383(10):989-992 [PMID: 32530583]
  79. Cell Stem Cell. 2021 Feb 4;28(2):331-342.e5 [PMID: 33450186]
  80. Adv Exp Med Biol. 2021;1312:1-17 [PMID: 33385178]
  81. Clin Microbiol Rev. 2021 Jan 13;34(2): [PMID: 33441314]
  82. Nat Protoc. 2019 Feb;14(2):518-540 [PMID: 30664680]
  83. JAMA Intern Med. 2020 Jul 1;180(7):934-943 [PMID: 32167524]
  84. Drug Discov Today. 2022 Apr;27(4):1062-1076 [PMID: 34954328]
  85. Nature. 2020 Dec;588(7839):670-675 [PMID: 33238290]
  86. N Engl J Med. 2020 Apr 23;382(17):e38 [PMID: 32268022]
  87. N Engl J Med. 2020 Nov 5;383(19):1813-1826 [PMID: 32445440]
  88. Lancet Infect Dis. 2022 Feb;22(2):209-221 [PMID: 34534511]
  89. Cell. 2020 Apr 16;181(2):271-280.e8 [PMID: 32142651]
  90. Science. 2020 Jul 3;369(6499):50-54 [PMID: 32358202]
  91. Elife. 2015 Mar 24;4: [PMID: 25803487]
  92. Science. 2005 Oct 28;310(5748):676-9 [PMID: 16195424]
  93. Front Public Health. 2020 Apr 29;8:152 [PMID: 32411652]
  94. Cell Stem Cell. 2020 Dec 3;27(6):876-889.e12 [PMID: 33232663]
  95. Br Med J. 1965 Jun 5;1(5448):1467-70 [PMID: 14288084]
  96. J Biomed Sci. 2021 Jan 12;28(1):9 [PMID: 33435929]
  97. Lancet Microbe. 2020 May;1(1):e14-e23 [PMID: 32835326]
  98. Proc Natl Acad Sci U S A. 2021 May 11;118(19): [PMID: 33906951]

MeSH Term

COVID-19
Humans
Lung
Models, Anatomic
Organoids
SARS-CoV-2
Journal Article Review Research Support, Non-U.S. Gov't
Article has an altmetric score of 1

Word Cloud

Created with Highcharts 10.0.0SARS-CoV-2lungorganoidsCOVID-19coronavirusinfectionstudiesvalueresearchexistingCoronavirusdisease-2019causedsevereacuterespiratorysyndrome2becomeglobalpandemicseverelyaffectedsocio-economicconditionspeople'slifemajortargetorganinfectedseriouslydamagedcomprehensiveunderstandingvirusmechanismfirstchoicesovercomeRecentdemonstratedenormoushumanplatformsvirologicalmakingidealtoolresearchinghost-pathogeninteractionsstudyvariousidentificationbiomarkersapplicationssummarizedtimesevencoronavirusescurrentlycapableinfectinghumansoutlinedFinallydetailedsummaryusingprovidedincludespathogenesisdrugdevelopmentprecisiontreatmentreviewhighlightsstudyingbringinghopewillalleviateCOVID-19-associatedinfectionsLungOrganoidsModelStudyInfectionorganoid

Similar Articles

Cited By