Jujuboside A Exhibits an Antiepileptogenic Effect in the Rat Model via Protection against Traumatic Epilepsy-Induced Oxidative Stress and Inflammatory Responses.
Wei Lu, Zhangze Wu, Chong Zhang, Tingting Gao, Xiaoyang Ling, Min Xu, Wenhua Wang, Xuegang Jin, Keran Li, Long Chen, Jinjuan Wang, Zhongyang Sun
Author Information
Wei Lu: Department of Neurosurgery, Kunshan Hospital of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Kunshan, China.
Zhangze Wu: Department of Neurosurgery, Air Force Hospital of Eastern Theater, Nanjing University of Chinese Medicine, Nanjing, China.
Chong Zhang: The First Retired Cadres' Sanatorium of Jiangsu Military Region, Nanjing, China.
Tingting Gao: Department of Neurosurgery, Air Force Hospital of Eastern Theater, Nanjing University of Chinese Medicine, Nanjing, China.
Xiaoyang Ling: Department of Neurosurgery, Kunshan Hospital of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Kunshan, China.
Min Xu: Department of Neurosurgery, Kunshan Hospital of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Kunshan, China.
Wenhua Wang: Department of Neurosurgery, Kunshan Hospital of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Kunshan, China.
Xuegang Jin: Department of Neurosurgery, Kunshan Hospital of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Kunshan, China.
Keran Li: Faculty of Life Science, School of Biomedical Science, University of Bristol, Bristol, UK.
Long Chen: Department of Neurosurgery, Kunshan Hospital of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Kunshan, China. ORCID
Jinjuan Wang: Department of Pharmacy, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. ORCID
Zhongyang Sun: Department of Orthopedics, Air Force Hospital of Eastern Theater, Nanjing University of Chinese Medicine, Nanjing, China. ORCID
Traumatic brain injuries (TBI) are the greatest source of death in trauma, and post-traumatic epilepsy (PTE) is one of the common complications of TBI. Oxidative stress and inflammatory responses play an important role in the process of PTE. Many studies have shown that Jujuboside A has powerful antioxidant and anti-inflammatory properties. However, it is not known whether Jujuboside A has an anti-epileptic effect. The influences of Jujuboside A in the experimental FeCl-induced model of PTE were tested by estimating the grade of seizures and performing behavioral tests. Following that, we detected oxidative stress indicators and inflammatory factors. Additionally, western blotting was used to test the protein levels of signaling molecules in MAPK pathways. In this study, Jujuboside A was found to have improved the recognition deficiency and epilepsy syndromes in the experimental rat model. Moreover, oxidative stress and inflammatory responses induced by FeCl injection were relieved by Jujuboside A. In addition, Jujuboside A was found to be capable of reducing the increased expression of p-P38 and p-ERK1/2 caused by iron ions. Collectively, our results demonstrated that Jujuboside A exhibits an antiepileptogenic effect by alleviating oxidative stress and inflammatory responses via the p38 and ERK1/2 pathways.
