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Journal of clinical medicine
Sep 17, 2022;11 (18):

Transesophageal Endoscopic Ultrasound Fine Needle Biopsy for the Diagnosis of Mediastinal Masses: A Retrospective Real-World Analysis.

Daniela Assisi, Filippo Tommaso Gallina, Daniele Forcella, Riccardo Tajè, Enrico Melis, Paolo Visca, Federico Pierconti, Emanuela Venti, Francesco Facciolo
Author Information
  1. Daniela Assisi: Digestive Endoscopy Unit, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.
  2. Filippo Tommaso Gallina: Thoracic Surgery Unit, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy. ORCID
  3. Daniele Forcella: Thoracic Surgery Unit, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.
  4. Riccardo Tajè: Thoracic Surgery Unit, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.
  5. Enrico Melis: Thoracic Surgery Unit, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.
  6. Paolo Visca: Department of Pathology, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.
  7. Federico Pierconti: Anesthesiology and Intensive Care Unit, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.
  8. Emanuela Venti: Anesthesiology and Intensive Care Unit, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.
  9. Francesco Facciolo: Thoracic Surgery Unit, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy. ORCID
PMID: 36143116 DOI: 10.3390/jcm11185469

Abstract

Endoscopic ultrasound (EUS) plays an important role in the diagnosis and staging of thoracic disease. Our report studies the diagnostic performance and clinical impact of EUS fine needle aspiration (FNA) in a homogenous cohort of patients according to the distribution of the enlarged MLNs or pulmonary masses. We retrospectively reviewed the diagnostic performance of 211 EUS-FNA in 200 consecutive patients with enlarged or PET-positive MLNs and para-mediastinal masses who were referred to our oncological center between January 2019 and May 2020. The overall sensitivity of EUS-FNA was 85% with a corresponding negative predictive value (NPV) of 56% and an accuracy of 87.5%. The sensitivity and accuracy in patients with abnormal MLNs were 81.1% and 84.4%, respectively. In those with para-mediastinal masses, sensitivity and accuracy were 96.4% and 96.8%. The accuracy for both masses and lymph nodes was 100%, and in the LAG (left adrenal gland), it was 66.6%. Our results show that, in patients with suspected mediastinal masses, EUS-FNA is an accurate technique to evaluate all reachable mediastinal nodal stations, including station 5.

Keywords

endoscopic ultrasound fine needle aspiration biopsy mediastinal lymph node para-mediastinal masses

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Journal Article

Word Cloud

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