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PHAGE (New Rochelle, N.Y.)
Mar 01, 2022;3 (1): 6-11.

inPhocus: Current State and Challenges of Phage Research in Singapore.

Navin Kumar Verma, Si Jia Tan, John Chen, Hanrong Chen, Muhammad Hafiz Ismail, Scott A Rice, Pablo Bifani, Sukumar Hariharan, Vivek Daniel Paul, Bharathi Sriram, Linh Chi Dam, Chia Ching Chan, Peiying Ho, Boon Chong Goh, Shimin Jasmine Chung, Kenneth Choon Meng Goh, Shu Hua Thong, Andrea Lay-Hoon Kwa, Adam Ostrowski, Thet Tun Aung, Halimah Razali, Shermaine W Y Low, Mani Shankar Bhattacharyya, Hemant K Gautam, Rajamani Lakshminarayanan, Thomas Sicheritz-Pontén, Martha R J Clokie, Wilfried Moreira, Maurice Adrianus Monique van Steensel
Author Information
  1. Navin Kumar Verma: Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore.
  2. Si Jia Tan: Institute for Health Technologies, Nanyang Technological University Singapore, Singapore.
  3. John Chen: Infectious Diseases Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  4. Hanrong Chen: Computational and Systems Biology, Genome Institute of Singapore, Singapore.
  5. Muhammad Hafiz Ismail: Singapore Centre for Environmental Life Sciences Engineering, Microbial Biofilms Cluster, Nanyang Technological University Singapore, Singapore.
  6. Scott A Rice: Singapore Centre for Environmental Life Sciences Engineering, Microbial Biofilms Cluster, Nanyang Technological University Singapore, Singapore.
  7. Pablo Bifani: Yong Loo Lin School of Medicine, National University of Singapore, ASTAR Infectious Diseases Labs, Singapore and the London School of Hygiene and Tropical Medicine, London, United Kingdom.
  8. Sukumar Hariharan: Gangagen Biotechnologies Private Ltd., Bangalore, India.
  9. Vivek Daniel Paul: Gangagen Biotechnologies Private Ltd., Bangalore, India.
  10. Bharathi Sriram: Antimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology Centre, Singapore.
  11. Linh Chi Dam: Antimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology Centre, Singapore.
  12. Chia Ching Chan: Antimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology Centre, Singapore.
  13. Peiying Ho: Antimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology Centre, Singapore.
  14. Boon Chong Goh: Antimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology Centre, Singapore.
  15. Shimin Jasmine Chung: Department of Infectious Diseases, Singapore General Hospital, Singapore.
  16. Kenneth Choon Meng Goh: Department of Microbiology, Singapore General Hospital, Singapore.
  17. Shu Hua Thong: Department of Pharmacy, Singapore General Hospital, Singapore.
  18. Andrea Lay-Hoon Kwa: Singhealth Duke-NUS Medicine Academic Clinical Programme, Singapore.
  19. Adam Ostrowski: Cellexus International Ltd., Dundee, United Kingdom.
  20. Thet Tun Aung: Department of Microbiology and Immunology, Immunology Translational Research Program and Centre for Life Science, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  21. Halimah Razali: Asian School of the Environment, Nanyang Technological University Singapore, Singapore.
  22. Shermaine W Y Low: Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore.
  23. Mani Shankar Bhattacharyya: CSIR-Institute of Microbial Technology, Chandigarh, India.
  24. Hemant K Gautam: CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.
  25. Rajamani Lakshminarayanan: Singapore Eye Research Institute, Singapore.
  26. Thomas Sicheritz-Pontén: Center for Evolutionary Hologenomics, The GLOBE Institute, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
  27. Martha R J Clokie: Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom.
  28. Wilfried Moreira: Department of Microbiology and Immunology, Immunology Translational Research Program and Centre for Life Science, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  29. Maurice Adrianus Monique van Steensel: Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore.
PMID: 36161195 DOI: 10.1089/phage.2022.29028.nkv

Abstract

Bacteriophages and phage-derived proteins are a promising class of antibacterial agents that experience a growing worldwide interest. To map ongoing phage research in Singapore and neighboring countries, Lee Kong Chian School of Medicine, Nanyang Technological University Singapore (NTU) and Yong Loo Lin School of Medicine, National University of Singapore (NUS) recently co-organized a virtual symposium on Bacteriophage and Bacteriophage-Derived Technologies, which was attended by more than 80 participants. Topics were discussed relating to phage life cycles, diversity, the roles of phages in biofilms and the human gut microbiome, engineered phage lysins to combat polymicrobial infections in wounds, and the challenges and prospects of clinical phage therapy. This perspective summarizes major points discussed during the symposium and new perceptions that emerged after the panel discussion.

Keywords

antimicrobial resistance ectolysin filamentous phages metagenomics recombinant phage proteins

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Journal Article
Article has an altmetric score of 8

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