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Revista do Instituto de Medicina Tropical de Sao Paulo
2022;64 e64.

The role of IFN-γ production during retroviral infections: an important cytokine involved in chronic inflammation and pathogenesis.

Patrícia Azevedo Soares Cordeiro, Tatiane Assone, Gabriela Prates, Marcia Regina Martinez Tedeschi, Luiz Augusto Marcondes Fonseca, Jorge Casseb
Author Information
  1. Patrícia Azevedo Soares Cordeiro: Universidade de São Paulo , Faculdade de Medicina , Instituto de Medicina Tropical de São Paulo , Laboratório de Investigação em Dermatologia e Imunodeficiências (LIM-56), São Paulo , São Paulo , Brazil. ORCID
  2. Tatiane Assone: Universidade de São Paulo , Faculdade de Medicina , Instituto de Medicina Tropical de São Paulo , Laboratório de Investigação em Dermatologia e Imunodeficiências (LIM-56), São Paulo , São Paulo , Brazil. ORCID
  3. Gabriela Prates: Universidade de São Paulo , Faculdade de Medicina , Instituto de Medicina Tropical de São Paulo , Laboratório de Investigação em Dermatologia e Imunodeficiências (LIM-56), São Paulo , São Paulo , Brazil. ORCID
  4. Marcia Regina Martinez Tedeschi: Universidade de São Paulo , Faculdade de Medicina , Instituto de Medicina Tropical de São Paulo , Laboratório de Investigação em Dermatologia e Imunodeficiências (LIM-56), São Paulo , São Paulo , Brazil. ORCID
  5. Luiz Augusto Marcondes Fonseca: Universidade de São Paulo , Faculdade de Medicina , Instituto de Medicina Tropical de São Paulo , Laboratório de Investigação em Dermatologia e Imunodeficiências (LIM-56), São Paulo , São Paulo , Brazil. ORCID
  6. Jorge Casseb: Universidade de São Paulo , Faculdade de Medicina , Instituto de Medicina Tropical de São Paulo , Laboratório de Investigação em Dermatologia e Imunodeficiências (LIM-56), São Paulo , São Paulo , Brazil. ORCID
PMID: 36197425 DOI: 10.1590/S1678-9946202264064

Abstract

Interferon-gamma (IFN-γ) plays a crucial role in viral infections by preventing viral replication and in the promotion of innate and adaptive immune responses. However, IFN-gamma can exert distinct effects in different persistent viral infections. The long-term overproduction of IFN-γ in retroviral infections, such as the human immunodeficiency virus (HIV), human T-lymphotropic virus type 1 (HTLV-1), and human endogenous retroviruses (HERVs), resulting in inflammation, may cause neuronal damage. This review is provocative about the role of IFN-γ during persistent retroviral infections and its relationship with the causation of some neurological disorders that are important for public health.

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MeSH Term

Cytokines
HIV Infections
Human T-lymphotropic virus 1
Humans
Inflammation
Interferon-gamma

Chemicals

Cytokines
Interferon-gamma
Journal Article Review
Article has an altmetric score of 2

Word Cloud

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