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Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences
Dec, 2022;30 (2): 331-341.

Mesoporous silica coated SPIONs containing curcumin and silymarin intended for breast cancer therapy.

Soosan Sadegha, Reyhaneh Varshochian, Pegah Dadras, Hosniyeh Hosseinzadeh, Ramin Sakhtianchi, Zahra Hadavand Mirzaie, Akram Shafiee, Fatemeh Atyabi, Rassoul Dinarvand
Author Information
  1. Soosan Sadegha: Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  2. Reyhaneh Varshochian: Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  3. Pegah Dadras: Trita Nanomedicine Research Center (TNRC), Trita Third Millennium Pharmaceuticals, Zanjan, Iran.
  4. Hosniyeh Hosseinzadeh: Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  5. Ramin Sakhtianchi: Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  6. Zahra Hadavand Mirzaie: Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  7. Akram Shafiee: Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  8. Fatemeh Atyabi: Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  9. Rassoul Dinarvand: Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. dinarvand@tums.ac.ir. ORCID
PMID: 36197594 DOI: 10.1007/s40199-022-00453-9

Abstract

INTRODUCTION: Super-paramagnetic iron oxide nanoparticles (SPIONs) are known as promising theranostic nano-drug carriers with magnetic resonance imaging (MRI) properties. Applying the herbaceous components with cytotoxic effects as cargos can suggest a new approach in the field of cancer-therapy. In this study mesoporous silica coated SPIONs (mSiO2@SPIONs) containing curcumin (CUR) and silymarin (SIL) were prepared and evaluated on breast cancer cell line, MCF-7.
METHODS: Nanoparticles (NPs) were formulated by reverse microemulsion method and characterized by DLS, SEM and VSM. The in vitro drug release, cellular cytotoxicity, and MRI properties of NPs were determined as well. The cellular uptake of NPs by MCF-7 cells was investigated through LysoTracker Red staining using confocal microscopy.
RESULTS: The MTT results showed that the IC50 of CUR + SIL loaded mSiO2@SPIONs was reduced about 50% in comparison with that of the free drug mixture. The NPs indicated proper MRI features and cellular uptake through endocytosis.
CONCLUSION: In conclusion the prepared formulation may offer a novel theranostic system for breast cancer researches.

Keywords

Curcumin Mesoporous silica Silymarin Superparamagnetic iron oxide nanoparticles Theranostic

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MeSH Term

Humans
Female
Curcumin
Silicon Dioxide
Breast Neoplasms
Magnetite Nanoparticles
Silymarin
Nanoparticles

Chemicals

Curcumin
Silicon Dioxide
Magnetite Nanoparticles
Silymarin
Journal Article
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Word Cloud

Created with Highcharts 10.0.0NPsSPIONsMRIsilicabreastcancercellularironoxidenanoparticlestheranosticpropertiescoatedmSiO2@SPIONscontainingcurcuminsilymarinpreparedMCF-7druguptakeMesoporousINTRODUCTION:Super-paramagneticknownpromisingnano-drugcarriersmagneticresonanceimagingApplyingherbaceouscomponentscytotoxiceffectscargoscansuggestnewapproachfieldcancer-therapystudymesoporousCURSILevaluatedcelllineMETHODS:NanoparticlesformulatedreversemicroemulsionmethodcharacterizedDLSSEMVSMvitroreleasecytotoxicitydeterminedwellcellsinvestigatedLysoTrackerRedstainingusingconfocalmicroscopyRESULTS:MTTresultsshowedIC50CUR + SILloadedreduced50%comparisonfreemixtureindicatedproperfeaturesendocytosisCONCLUSION:conclusionformulationmayoffernovelsystemresearchesintendedtherapyCurcuminSilymarinSuperparamagneticTheranostic

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