High risk of developing dementia in Parkinson's disease: a Swedish registry-based study.
Daniel Oudin Åström, Jacob Simonsen, Lars Lau Raket, Simona Sgarbi, Johan Hellsten, Peter Hagell, Jenny M Norlin, Klas Kellerborg, Pablo Martinez-Martin, Per Odin
Author Information
Daniel Oudin Åström: H Lundbeck A/S, Ottiliavej 9, 2500, Valby, Denmark. aast@lundbeck.com.
Jacob Simonsen: H Lundbeck A/S, Ottiliavej 9, 2500, Valby, Denmark.
Lars Lau Raket: H Lundbeck A/S, Ottiliavej 9, 2500, Valby, Denmark.
Simona Sgarbi: H Lundbeck A/S, Ottiliavej 9, 2500, Valby, Denmark.
Johan Hellsten: H Lundbeck A/S, Ottiliavej 9, 2500, Valby, Denmark.
Peter Hagell: The PRO-CARE Group, Faculty of Health Sciences, Kristianstad University, Kristianstad, Sweden.
Jenny M Norlin: The Swedish Institute for Health Economics, Lund, Sweden.
Klas Kellerborg: The Swedish Institute for Health Economics, Lund, Sweden.
Pablo Martinez-Martin: Center for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED), Carlos III Institute of Health, Madrid, Spain.
Per Odin: Division of Neurology, Department of Clinical Sciences, Lund University, Lund, Sweden.
Dementia have substantial negative impact on the affected individual, their care partners and society. Persons living with Parkinson's disease (PwP) are also to a large extent living with dementia. The aim of this study is to estimate time to dementia in PD using data from a large quality register with access to baseline clinical and patient reported data merged with Swedish national health registries. Persons with Parkinson's disease in the Swedish Neuro Registries/Parkinson's Disease Swedish PD Registry (PARKreg) in Sweden were included and linked to national health registries and matched by sex and age to controls without PD. Time to dementia was analysed with Cox regression models assuming proportional hazards, with time since diagnosis as the underlying time variable. In this large prospective cohort study, PwP had approximately four times higher risk of developing dementia as compared to age and sex-matched controls, a finding which remained after adjusting for potential confounders. The present results underline the high risk of dementia in PD and further emphasize the importance of developing symptomatic and ultimately disease modifying strategies to counteract this part of the non-motor symptomatology in PD.
References
Lancet. 2015 Oct 24;386(10004):1683-97
[PMID: 26595642]
J Int Neuropsychol Soc. 2021 Aug;27(7):722-732
[PMID: 33303048]
Ann Clin Transl Neurol. 2020 Apr;7(4):449-461
[PMID: 32285645]
Life (Basel). 2021 Nov 16;11(11):
[PMID: 34833115]
