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10, 2022;18 (10): e1010805.

An introduction to the Marburg virus vaccine consortium, MARVAC.

Robert W Cross, Ira M Longini, Stephan Becker, Karin Bok, David Boucher, Miles W Carroll, Janet V Díaz, William E Dowling, Ruxandra Draghia-Akli, James T Duworko, John M Dye, Michael A Egan, Patricia Fast, Amy Finan, Courtney Finch, Thomas R Fleming, Joan Fusco, Thomas W Geisbert, Anthony Griffiths, Stephan Günther, Lisa E Hensley, Anna Honko, Ruth Hunegnaw, Jocelyn Jakubik, Julie Ledgerwood, Kerstin Luhn, Demetrius Matassov, Jeffrey Meshulam, Emily V Nelson, Christopher L Parks, Roxana Rustomjee, David Safronetz, Lauren M Schwartz, Dean Smith, Paul Smock, Ydrissa Sow, Christina F Spiropoulou, Nancy J Sullivan, Kelly L Warfield, Daniel Wolfe, Courtney Woolsey, Roland Zahn, Ana María Henao-Restrepo, César Muñoz-Fontela, Andrea Marzi
Author Information
  1. Robert W Cross: Galveston National Laboratory, and Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.
  2. Ira M Longini: Department of Biostatistics, University of Florida, Gainesville, Florida, United States of America.
  3. Stephan Becker: Institute for Virology, Philipps-Universität Marburg, Marburg, Germany.
  4. Karin Bok: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
  5. David Boucher: U.S. COVID-19 Response at U.S. Department of Health and Human Services, Washington, DC, United States of America.
  6. Miles W Carroll: Pandemic Sciences Institute, Nuffield Department of Medicine, Oxford University, United Kingdom.
  7. Janet V Díaz: World Health Organization, Geneva, Switzerland.
  8. William E Dowling: Coalition for Epidemic Preparedness Innovations (CEPI), Washington, Washington, DC, United States of America.
  9. Ruxandra Draghia-Akli: Johnson & Johnson-Global Public Health Research and Development, Spring House, Pennsylvania, United States of America.
  10. James T Duworko: Partnership for Research on Infectious Diseases in Liberia, Monrovia, Liberia.
  11. John M Dye: Virology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America.
  12. Michael A Egan: Auro Vaccines, Pearl River, New York, United States of America.
  13. Patricia Fast: IAVI, New York, New York, United States of America.
  14. Amy Finan: Sabin vaccine Institute, Washington, DC, United States of America.
  15. Courtney Finch: Sabin vaccine Institute, Washington, DC, United States of America.
  16. Thomas R Fleming: University of Washington, Seattle, Washington, United States of America.
  17. Joan Fusco: Public Health Vaccines, Cambridge, Massachusetts, United States of America.
  18. Thomas W Geisbert: Galveston National Laboratory, and Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.
  19. Anthony Griffiths: National Emerging Infectious Diseases Laboratories, Boston University School of Medicine, Boston, Maryland, United States of America.
  20. Stephan Günther: Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
  21. Lisa E Hensley: Integrated Research Facility, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland, United States of America.
  22. Anna Honko: National Emerging Infectious Diseases Laboratories, Boston University School of Medicine, Boston, Maryland, United States of America.
  23. Ruth Hunegnaw: Immune Biology of Retroviral Infection Section, Vaccine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
  24. Jocelyn Jakubik: Sabin vaccine Institute, Washington, DC, United States of America.
  25. Julie Ledgerwood: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
  26. Kerstin Luhn: Janssen Vaccines & Prevention, Leiden, the Netherlands.
  27. Demetrius Matassov: Auro Vaccines, Pearl River, New York, United States of America.
  28. Jeffrey Meshulam: Auro Vaccines, Pearl River, New York, United States of America.
  29. Emily V Nelson: Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
  30. Christopher L Parks: IAVI, New York, New York, United States of America.
  31. Roxana Rustomjee: Sabin vaccine Institute, Washington, DC, United States of America.
  32. David Safronetz: Zoonotic Diseases and Special Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
  33. Lauren M Schwartz: World Health Organization, Geneva, Switzerland.
  34. Dean Smith: Bacterial and Combination Vaccines, Public Health Agency of Canada, Ottawa, Ontario, Canada.
  35. Paul Smock: Sabin vaccine Institute, Washington, DC, United States of America.
  36. Ydrissa Sow: Collaborative Clinical Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America.
  37. Christina F Spiropoulou: Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
  38. Nancy J Sullivan: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
  39. Kelly L Warfield: Emergent BioSolutions, Gaithersburg, Maryland, United States of America.
  40. Daniel Wolfe: Bacterial and Combination Vaccines, Public Health Agency of Canada, Ottawa, Ontario, Canada.
  41. Courtney Woolsey: Galveston National Laboratory, and Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.
  42. Roland Zahn: Janssen Vaccines & Prevention, Leiden, the Netherlands.
  43. Ana María Henao-Restrepo: World Health Organization, Geneva, Switzerland.
  44. César Muñoz-Fontela: Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
  45. Andrea Marzi: Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America. ORCID
PMID: 36227853 DOI: 10.1371/journal.ppat.1010805

Abstract

The emergence of Marburg virus (MARV) in Guinea and Ghana triggered the assembly of the MARV vaccine "MARVAC" consortium representing leaders in the field of vaccine research and development aiming to facilitate a rapid response to this infectious disease threat. Here, we discuss current progress, challenges, and future directions for MARV vaccines.

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Grants

  1. R37 AI029168/NIAID NIH HHS
  2. R56 AI148284/NIAID NIH HHS
  3. R01 AI139761/NIAID NIH HHS
  4. HHSN272200800056C/NIAID NIH HHS
  5. U19 AI142785/NIAID NIH HHS
  6. 001/World Health Organization
  7. U01 AI151801/NIAID NIH HHS
  8. UM1 AI068617/NIAID NIH HHS

MeSH Term

Animals
Humans
Marburg Virus Disease
Marburgvirus
Viral Vaccines

Chemicals

Viral Vaccines
Journal Article Research Support, N.I.H., Intramural Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.
Article has an altmetric score of 158

Word Cloud

Created with Highcharts 10.0.0MARVvaccineMarburgvirusconsortiumemergenceGuineaGhanatriggeredassembly"MARVAC"representingleadersfieldresearchdevelopmentaimingfacilitaterapidresponseinfectiousdiseasethreatdiscusscurrentprogresschallengesfuturedirectionsvaccinesintroductionMARVAC

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