Implementing Risk-Stratified Breast Screening in England: An Agenda Setting Meeting.

Lorna McWilliams, D Gareth Evans, Katherine Payne, Fiona Harrison, Anthony Howell, Sacha J Howell, David P French, Breast Screening Risk-Stratification Agenda Setting Group
Author Information
  1. Lorna McWilliams: Manchester Centre for Health Psychology, Division of Psychology & Mental Health, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
  2. D Gareth Evans: NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester M13 9WU, UK. ORCID
  3. Katherine Payne: NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester M13 9WU, UK. ORCID
  4. Fiona Harrison: Patient representative.
  5. Anthony Howell: NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester M13 9WU, UK.
  6. Sacha J Howell: NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester M13 9WU, UK.
  7. David P French: Manchester Centre for Health Psychology, Division of Psychology & Mental Health, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester M13 9PL, UK. ORCID

Abstract

It is now possible to accurately assess breast cancer risk at routine NHS Breast Screening Programme (NHSBSP) appointments, provide risk feedback and offer risk management strategies to women at higher risk. These strategies include National Institute for Health and Care Excellence (NICE) approved additional breast screening and risk-reducing medication. However, the NHSBSP invites nearly all women three-yearly, regardless of risk. In March 2022, a one-day agenda setting meeting took place in Manchester to discuss the feasibility and desirability of implementation of risk-stratified screening in the NHSBSP. Fifty-eight individuals participated (38 face-to-face, 20 virtual) with relevant expertise from academic, clinical and/or policy-making perspectives. Key findings were presented from the PROCAS2 NIHR programme grant regarding feasibility of risk-stratified screening in the NHSBSP. Participants discussed key uncertainties in seven groups, followed by a plenary session. Discussions were audio-recorded and thematically analysed to produce descriptive themes. Five themes were developed: (i) risk and health economic modelling; (ii) health inequalities and communication with women; (iii); extending screening intervals for low-risk women; (iv) integration with existing NHSBSP; and (v) potential new service models. Most attendees expected some form of risk-stratified breast screening to be implemented in England and collectively identified key issues to be resolved to facilitate this.

Keywords

References

  1. Genet Med. 2019 Aug;21(8):1708-1718 [PMID: 30643217]
  2. BMC Cancer. 2022 Jan 16;22(1):69 [PMID: 35033023]
  3. BMJ Open. 2022 May 4;12(5):e058635 [PMID: 35508345]
  4. BMC Public Health. 2018 Jan 25;18(1):178 [PMID: 29370783]
  5. JAMA Oncol. 2018 Sep 1;4(9):e180174 [PMID: 29621362]
  6. J Med Screen. 2017 Sep;24(3):127-145 [PMID: 27754937]
  7. Psychooncology. 2018 Apr;27(4):1089-1099 [PMID: 29080378]
  8. Br J Cancer. 2016 Apr 26;114(9):1045-52 [PMID: 27022688]
  9. Fam Cancer. 2021 Jan;20(1):13-21 [PMID: 32524330]
  10. BMJ Open. 2020 Dec 23;10(12):e044597 [PMID: 33361170]
  11. Genet Med. 2021 Nov;23(11):2114-2121 [PMID: 34230637]
  12. PLoS One. 2018 Jun 1;13(6):e0197772 [PMID: 29856760]
  13. J Community Genet. 2018 Apr;9(2):103-116 [PMID: 28952070]
  14. Patient Educ Couns. 2022 Aug;105(8):2757-2762 [PMID: 35440375]
  15. J Pers Med. 2021 Jun 10;11(6): [PMID: 34200634]
  16. Curr Oncol. 2016 Dec;23(6):e615-e625 [PMID: 28050152]
  17. Breast. 2022 Apr;62:16-21 [PMID: 35114637]
  18. Med J Aust. 2021 Oct 18;215(8):359-365 [PMID: 34374095]
  19. J Pers Med. 2021 Feb 02;11(2): [PMID: 33540785]
  20. J Med Screen. 2020 Sep;27(3):138-145 [PMID: 31701797]
  21. Stat Med. 2004 Apr 15;23(7):1111-30 [PMID: 15057881]
  22. Cancer Prev Res (Phila). 2012 Jul;5(7):943-51 [PMID: 22581816]
  23. Br J Cancer. 2020 Feb;122(3):329-332 [PMID: 31761901]
  24. J Med Screen. 2020 Sep;27(3):130-137 [PMID: 31791172]
  25. J Med Screen. 2011;18(2):96-102 [PMID: 21852703]
  26. Br J Cancer. 2021 Aug;125(4):611-617 [PMID: 34040176]
  27. Breast Cancer Res. 2007;9(5):213 [PMID: 17888188]
  28. Int J Epidemiol. 2022 Jan 6;50(6):1897-1911 [PMID: 34999890]
  29. Cancers (Basel). 2021 Aug 18;13(16): [PMID: 34439302]
  30. Br J Cancer. 2015 Feb 3;112(3):562-6 [PMID: 25535731]
  31. Pilot Feasibility Stud. 2021 Dec 20;7(1):220 [PMID: 34930478]
  32. Breast Cancer Res. 2015 Dec 01;17(1):147 [PMID: 26627479]
  33. Aust N Z J Public Health. 2022 Apr;46(2):230-236 [PMID: 35112749]
  34. BMC Womens Health. 2022 May 2;22(1):142 [PMID: 35501791]
  35. NPJ Breast Cancer. 2017 Sep 13;3:34 [PMID: 28944288]
  36. BMC Cancer. 2021 May 29;21(1):637 [PMID: 34051753]
  37. PLoS One. 2022 Feb 4;17(2):e0263788 [PMID: 35120169]
  38. Cancers (Basel). 2021 Nov 19;13(22): [PMID: 34830965]
  39. Eur Radiol. 2022 Jun;32(6):4036-4045 [PMID: 35258677]
  40. BMC Med. 2022 Feb 11;20(1):72 [PMID: 35151316]
  41. Br J Cancer. 2018 Jun;118(12):1648-1657 [PMID: 29736008]
  42. Womens Health (Lond). 2021 Jan-Dec;17:17455065211009746 [PMID: 33877937]
  43. Nat Rev Clin Oncol. 2020 Nov;17(11):687-705 [PMID: 32555420]
  44. Genet Med. 2022 Sep 3;: [PMID: 36057905]
  45. Genet Med. 2022 Jul;24(7):1485-1494 [PMID: 35426792]
  46. Climacteric. 2017 Aug;20(4):313-320 [PMID: 28661704]
  47. Public Health Rev. 2019 Feb 28;40:2 [PMID: 30858992]
  48. Healthc Policy. 2019 Nov;15(2):39-54 [PMID: 32077844]
  49. Br J Cancer. 2013 Jun 11;108(11):2205-40 [PMID: 23744281]
  50. Front Genet. 2017 Sep 21;8:128 [PMID: 28983318]
  51. J Pers Med. 2021 Jun 04;11(6): [PMID: 34199804]
  52. BMC Cancer. 2019 Dec 4;19(1):1089 [PMID: 31795966]
  53. Genet Med. 2022 Jan;24(1):146-156 [PMID: 34906505]
  54. Breast. 2018 Jun;39:24-32 [PMID: 29529454]
  55. Breast Cancer Res Treat. 2019 Jul;176(1):141-148 [PMID: 30941651]
  56. BMC Cancer. 2020 May 20;20(1):452 [PMID: 32434564]
  57. BMC Cancer. 2020 Jun 18;20(1):570 [PMID: 32552763]
  58. Int J Cancer. 2022 Jan 1;150(1):73-79 [PMID: 34460111]
  59. Br J Cancer. 2022 Mar;126(4):533-550 [PMID: 34703006]
  60. BMC Cancer. 2020 Jul 22;20(1):680 [PMID: 32698780]
  61. Value Health. 2017 Sep;20(8):1100-1109 [PMID: 28964442]

Grants

  1. RP-PG-1214-20016; IS-BRC-1215-20007/National Institute for Health Research
  2. 2018RP005/Breast Cancer Now
  3. GA18-001/Prevent Breast Cancer

Word Cloud

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