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International journal of molecular sciences
Oct 18, 2022;23 (20):

An Original and Efficient Antibiotic Adjuvant Strategy to Enhance the Activity of Macrolide Antibiotics against Gram-Negative Resistant Strains.

Azza Troudi, Jean Michel Bolla, Naouel Klibi, Jean Michel Brunel
Author Information
  1. Azza Troudi: Aix Marseille Universit��, INSERM, SSA, MCT, 13385 Marseille, France.
  2. Jean Michel Bolla: Aix Marseille Universit��, INSERM, SSA, MCT, 13385 Marseille, France. ORCID
  3. Naouel Klibi: Laboratory of Microorganisms and Active Biomolecules, Department of Biology, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis 1068, Tunisia.
  4. Jean Michel Brunel: Aix Marseille Universit��, INSERM, SSA, MCT, 13385 Marseille, France. ORCID
PMID: 36293314 DOI: 10.3390/ijms232012457

Abstract

Gram-negative bacteria were reported as a significant cause of infections in both community and nosocomial settings. Considered as one of the greatest threats to public health, the spread of bacteria drug resistance and the lack of effective alternative treatment options remains problematic. Herein, we report a promising strategy to combat Gram-negative resistant strains consisting of the combination of a macrolide antibiotic with a polyaminoisoprenyl adjuvant derivative leading to a significant decrease of antibiotic resistance.

Keywords

Gram-negative bacterial strains antibiotic adjuvants macrolide antibiotics outer membrane polyamines polyaminoisoprenyl derivatives

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MeSH Term

Anti-Bacterial Agents
Gram-Negative Bacteria
Macrolides
Drug Resistance, Bacterial
Adjuvants, Pharmaceutic
Microbial Sensitivity Tests
Drug Resistance, Multiple, Bacterial

Chemicals

Anti-Bacterial Agents
Macrolides
Adjuvants, Pharmaceutic
Journal Article
Article has an altmetric score of 1

Word Cloud

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