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BMC infectious diseases
Nov 07, 2022;22 (1): 819.

Prevalence of Hepatitis B Virus infection in the Gulf Cooperation Council: a systematic review and meta-analysis.

Ali A Alali, Mahmoud N Abo-Shehada
Author Information
  1. Ali A Alali: Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, University of London, London, UK. alali.a@ku.edu.kw.
  2. Mahmoud N Abo-Shehada: Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, University of London, London, UK.
PMID: 36344923 DOI: 10.1186/s12879-022-07806-4

Abstract

BACKGROUND: Hepatitis B virus (HBV) infection is a global public-health problem. Since the introduction of an effective vaccine, the epidemiology of HBV infection is changing. We aimed to estimate the prevalence of HBV infection in the Gulf Cooperation Council (GCC) region and delineate any variation in member-countries, special sub-groups, and over time.
METHODS: This is a systematic review and meta-analysis to review studies of HBV prevalence in the GCC region. Databases were searched and all studies from inception to July 31st, 2021, were considered for inclusion. The pooled HBV prevalence was analyzed using the random-effect model after assessment for heterogeneity. True prevalence was adjusted using the Rogan-Gladen estimator. Pre-defined subgroup analysis was performed, and publication bias was assessed.
RESULTS: Overall, 99 studies (n = 1,944,200 participants) met the inclusion criteria. The overall HBV apparent prevalence was 3.05% (95% CI 2.60, 3.52) and the true prevalence was 1.67% (95% CI 1.66, 1.68). The apparent prevalence varied between subgroups. Over time, the apparent prevalence of HBV infection has declined from 9.38% (95% CI 7.26, 11.74) before 1990 to 1.56% (95% CI 1.07, 2.12) during the period 2010 to 2020.
CONCLUSION: Over the last four decades the overall prevalence of HBV infection in the GCC region has decreased from high- to low-endemicity level. However, due to poor methodology of the included studies, further high-quality community-based studies are needed to obtain more precise estimate of HBV infection in this region.

Keywords

Arabian Gulf Gulf Cooperation Council Hepatitis B virus Prevalence Systematic review

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MeSH Term

Humans
Hepatitis B virus
Prevalence
Hepatitis B
Hepatitis B Surface Antigens

Chemicals

Hepatitis B Surface Antigens
Meta-Analysis Systematic Review Journal Article
Article has an altmetric score of 2

Word Cloud

Created with Highcharts 10.0.0HBVprevalenceinfectionstudies1Gulfregionreview95%CIHepatitisBCooperationGCCapparentvirusestimateCounciltimesystematicmeta-analysisinclusionusingoverall32PrevalenceBACKGROUND:globalpublic-healthproblemSinceintroductioneffectivevaccineepidemiologychangingaimeddelineatevariationmember-countriesspecialsub-groupsMETHODS:DatabasessearchedinceptionJuly31st2021consideredpooledanalyzedrandom-effectmodelassessmentheterogeneityTrueadjustedRogan-GladenestimatorPre-definedsubgroupanalysisperformedpublicationbiasassessedRESULTS:Overall99n = 1944200participantsmetcriteria05%6052true67%6668variedsubgroupsdeclined938%7261174199056%0712period20102020CONCLUSION:lastfourdecadesdecreasedhigh-low-endemicitylevelHoweverduepoormethodologyincludedhigh-qualitycommunity-basedneededobtainpreciseVirusCouncil:ArabianSystematic

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