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Experimental and clinical psychopharmacology
Jun, 2023;31 (3): 724-732.

Effects of short-term nicotine deprivation on delay discounting among young, experienced, exclusive ENDS users: An initial study.

Irene Pericot-Valverde, Jin H Yoon, Kaileigh A Byrne, Moonseong Heo, Jiajing Niu, Alain H Litwin, Diann E Gaalema
Author Information
  1. Irene Pericot-Valverde: Department of Psychology, Clemson University. ORCID
  2. Jin H Yoon: Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston.
  3. Kaileigh A Byrne: Department of Psychology, Clemson University.
  4. Moonseong Heo: Prisma Health Addiction Research Center.
  5. Jiajing Niu: Prisma Health Addiction Research Center.
  6. Alain H Litwin: Prisma Health Addiction Research Center. ORCID
  7. Diann E Gaalema: Vermont Center on Behavior and Health, University of Vermont.
PMID: 36355684 DOI: 10.1037/pha0000612

Abstract

Delay discounting describes how rapidly delayed rewards lose value as a function of delay and serves as one measure of impulsive decision-making. Nicotine deprivation among combustible cigarette smokers can increase delay discounting. We aimed to explore changes in discounting following nicotine deprivation among electronic nicotine delivery systems (ENDS) users. Thirty young adults (aged 18-24 years) that exclusively used ENDS participated in two laboratory sessions: one with vaping as usual and another after 16 hr of nicotine deprivation (biochemically assessed). At each session, participants completed a craving measure and three hypothetical delay discounting tasks presenting choices between small, immediate rewards and large, delayed ones (money-money; e-liquid-e-liquid; e-liquid-money). Craving for ENDS significantly increased during short-term nicotine deprivation relative to normal vaping. Delay discounting rates in the e-liquid now versus money later task increased (indicating a shift in preference for smaller, immediate rewards) following short-term nicotine deprivation relative to vaping as usual, but no changes were observed in the other two discounting tasks. Short-term nicotine deprivation increased the preference for smaller amounts of e-liquid delivered immediately over larger, monetary awards available after a delay in this first study of its kind. As similar preference shifts for drug now versus money later have been shown to be indicative of increased desire to use drug as well as relapse risk, the findings support the utility of the current model as a platform to explore interventions that can mitigate these preference shifts. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Associated Data

ClinicalTrials.gov | NCT04522362

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Grants

  1. P20 GM103644/NIGMS NIH HHS
  2. P50 DA036114/NIDA NIH HHS
  3. U54 DA036114/NIDA NIH HHS
  4. /FDA HHS

MeSH Term

Young Adult
Humans
Nicotine
Delay Discounting
Reward
Impulsive Behavior
Vaping

Chemicals

Nicotine
Journal Article
Article has an altmetric score of 1

Word Cloud

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