OpenLB
Open Library of Bioscience
Advanced Search
Cells
11 02, 2022;11 (21):

Hematopoietic Stem Cell Transplantation in Refractory Crohn's Disease: Should It Be Considered?

Simon Reider, Lukas Binder, Stefan Fürst, Stefan Hatzl, Andreas Blesl
Author Information
  1. Simon Reider: Christian Doppler Laboratory for Mucosal Immunology, Johannes Kepler University Linz, 4020 Linz, Austria.
  2. Lukas Binder: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria.
  3. Stefan Fürst: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria. ORCID
  4. Stefan Hatzl: Intensive Care Unit, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria. ORCID
  5. Andreas Blesl: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria. ORCID
PMID: 36359859 DOI: 10.3390/cells11213463

Abstract

Hematopoietic stem cell transplantation (HSCT) is widely used in benign and malignant hematological diseases. During the last decade, HSCT, mainly autologous, also gained increasing attention in the treatment of refractory autoimmune diseases. Crohn's disease (CD) is an inflammatory bowel disease leading to transmural inflammation potentially affecting all parts of the luminal gastrointestinal tract. Despite improving therapeutic options, including various biologics, some patients are refractory to all lines of available conservative therapy, leading to increased morbidity and reduced quality of life. Apart from surgery, HSCT might be a reasonable treatment alternative for refractory CD patients. This review aims to describe the current role of HSCT in CD and discusses the procedure, the correct patient selection, the clinical efficacy from initial remission to following relapse rates, and complications of this treatment.

Keywords

Crohn’s disease chemotherapy hematopoietic stem cell transplantation inflammatory bowel disease

References

  1. Nat Rev Rheumatol. 2017 Apr;13(4):244-256 [PMID: 28228650]
  2. Blood. 2010 Dec 23;116(26):6123-32 [PMID: 20837778]
  3. Bone Marrow Transplant. 2012 Jun;47(6):770-90 [PMID: 22002489]
  4. Blood. 2022 Mar 10;139(10):1452-1468 [PMID: 34724567]
  5. Lancet. 2017 Apr 29;389(10080):1741-1755 [PMID: 27914655]
  6. J Crohns Colitis. 2022 Jan 28;16(1):27-38 [PMID: 34402887]
  7. Dis Colon Rectum. 2012 Aug;55(8):864-9 [PMID: 22810471]
  8. Support Care Cancer. 2017 Oct;25(10):3085-3093 [PMID: 28439725]
  9. Gut. 2019 Mar;68(3):423-433 [PMID: 29363534]
  10. N Engl J Med. 2016 Nov 17;375(20):1946-1960 [PMID: 27959607]
  11. Infection. 2012 Jun;40(3):271-8 [PMID: 22187340]
  12. Gut. 2016 Sep;65(9):1456-62 [PMID: 26585938]
  13. Chest. 2012 Feb;141(2):442-450 [PMID: 21778261]
  14. Haematologica. 2010 Feb;95(2):185-8 [PMID: 20139390]
  15. Gastroenterology. 2022 May;162(6):1650-1664.e8 [PMID: 35134323]
  16. Am J Transplant. 2019 Sep;19(9):2479-2494 [PMID: 31247126]
  17. Rambam Maimonides Med J. 2014 Oct 29;5(4):e0028 [PMID: 25386344]
  18. J Crohns Colitis. 2018 Mar 28;12(4):476-488 [PMID: 29325112]
  19. Blood. 2007 Mar 15;109(6):2643-548 [PMID: 17119125]
  20. J Crohns Colitis. 2017 Oct 01;11(10):1161-1168 [PMID: 28419282]
  21. Aliment Pharmacol Ther. 2022 Apr;55(7):789-804 [PMID: 35166398]
  22. Blood. 2020 Jul 16;136(3):362-369 [PMID: 32483623]
  23. Cureus. 2022 May 7;14(5):e24807 [PMID: 35686267]
  24. Front Immunol. 2018 Apr 04;9:646 [PMID: 29670622]
  25. Inflamm Bowel Dis. 2017 Jan;23(1):133-142 [PMID: 28002130]
  26. JAMA. 2015 Dec 15;314(23):2524-34 [PMID: 26670970]
  27. Hematol Transfus Cell Ther. 2021 Jan-Mar;43(1):65-86 [PMID: 32418777]
  28. Mayo Clin Proc. 2017 Jul;92(7):1088-1103 [PMID: 28601423]
  29. Cochrane Database Syst Rev. 2022 May 13;5:CD013070 [PMID: 35556242]
  30. Gastroenterology. 2020 Jun;158(8):2123-2138.e8 [PMID: 32044319]
  31. Gastroenterology. 2014 Nov;147(5):990-1007.e3 [PMID: 25058236]
  32. Bone Marrow Transplant. 2016 Apr;51(4):553-9 [PMID: 26752142]
  33. Blood. 2005 Oct 15;106(8):2912-9 [PMID: 15994282]
  34. J Rheumatol. 2006 Sep;33(9):1878-80 [PMID: 16832843]
  35. QJM. 2014 Nov;107(11):871-7 [PMID: 24803477]
  36. Inflamm Bowel Dis. 2012 Nov;18(11):2107-19 [PMID: 22419649]
  37. Clin Gastroenterol Hepatol. 2022 Apr;20(4):e653-e663 [PMID: 33746097]
  38. Am J Hematol. 1993 Jun;43(2):157-8 [PMID: 8342550]
  39. Curr Treat Options Cardiovasc Med. 2016 Apr;18(4):25 [PMID: 26909819]
  40. Bone Marrow Transplant. 2003 Aug;32 Suppl 1:S57-9 [PMID: 12931244]
  41. Transplantation. 2003 May 27;75(10):1745-7 [PMID: 12777867]
  42. Lancet. 2022 May 28;399(10340):2015-2030 [PMID: 35644154]
  43. J Crohns Colitis. 2018 Aug 29;12(9):1097-1103 [PMID: 29788233]
  44. J Crohns Colitis. 2020 Jan 1;14(1):4-22 [PMID: 31711158]
  45. Leukemia. 2007 Jul;21(7):1387-94 [PMID: 17410187]
  46. Bone Marrow Transplant. 2020 Dec;55(12):2343-2346 [PMID: 32467584]
  47. Annu Rev Immunol. 2010;28:573-621 [PMID: 20192811]
  48. Bone Marrow Transplant. 2001 Jul;28(1):1-12 [PMID: 11498738]
  49. Curr Res Transl Med. 2016 Apr-Jun;64(2):71-82 [PMID: 27316390]
  50. Gut. 2008 Feb;57(2):211-7 [PMID: 17895357]
  51. Blood Adv. 2020 Dec 22;4(24):6283-6290 [PMID: 33351121]
  52. Lancet Gastroenterol Hepatol. 2017 Jun;2(6):399-406 [PMID: 28497755]
  53. Inflamm Bowel Dis. 2004 Nov;10(6):892-4 [PMID: 15626911]
  54. Bone Marrow Transplant. 2007 Mar;39(6):317-29 [PMID: 17277794]
  55. Blood. 2003 Mar 1;101(5):2064-6 [PMID: 12393477]
  56. Stem Cells. 2013 Nov;31(11):2575-81 [PMID: 23404825]
  57. Aliment Pharmacol Ther. 2012 Oct;36(8):725-35 [PMID: 22937722]
  58. Dis Colon Rectum. 1996 Nov;39(11):1199-203 [PMID: 8918424]
  59. J Crohns Colitis. 2020 Feb 10;14(2):155-168 [PMID: 31742338]
  60. Intest Res. 2020 Jan;18(1):79-84 [PMID: 32013316]
  61. Cureus. 2020 May 29;12(5):e8351 [PMID: 32617224]
  62. Gut. 2007 Sep;56(9):1232-9 [PMID: 17299059]
  63. Lancet Gastroenterol Hepatol. 2021 Jul;6(7):520-522 [PMID: 34019799]
  64. J Crohns Colitis. 2011 Dec;5(6):543-9 [PMID: 22115372]
  65. Bone Marrow Transplant. 2000 Oct;26(8):921-3 [PMID: 11081397]
  66. Gastroenterology. 1998 Mar;114(3):433-40 [PMID: 9496932]
  67. Cancer Invest. 2014 Aug;32(7):349-62 [PMID: 24902046]
  68. Br J Haematol. 1998 Dec;103(3):651-2 [PMID: 9858212]
  69. Bone Marrow Transplant. 2019 Jul;54(7):933-942 [PMID: 30705338]
  70. Gastroenterol Hepatol. 2019 Jan;42(1):16-22 [PMID: 30337206]
  71. Curr Opin Gastroenterol. 2021 Jul 1;37(4):357-363 [PMID: 34059604]
  72. World J Stem Cells. 2018 Oct 26;10(10):134-137 [PMID: 30397423]

MeSH Term

Humans
Crohn Disease
Quality of Life
Hematopoietic Stem Cell Transplantation
Transplantation, Autologous
Inflammatory Bowel Diseases
Chronic Disease
Journal Article Review
Article has an altmetric score of 2

Word Cloud

Created with Highcharts 10.0.0HSCTdiseasetreatmentrefractoryCDHematopoieticstemcelltransplantationdiseasesCrohn'sinflammatorybowelleadingpatientswidelyusedbenignmalignanthematologicallastdecademainlyautologousalsogainedincreasingattentionautoimmunetransmuralinflammationpotentiallyaffectingpartsluminalgastrointestinaltractDespiteimprovingtherapeuticoptionsincludingvariousbiologicslinesavailableconservativetherapyincreasedmorbidityreducedqualitylifeApartsurgerymightreasonablealternativereviewaimsdescribecurrentrolediscussesprocedurecorrectpatientselectionclinicalefficacyinitialremissionfollowingrelapseratescomplicationsStemCellTransplantationRefractoryDisease:Considered?Crohn’schemotherapyhematopoietic

Similar Articles

Cited By