[Phage therapy for respiratory infections].

Georgia Mitropoulou, Pieter-Jan Gijs, Angela Koutsokera, Alain Sauty, Sylvain Blanchon, Chantal Csajka, Jean-François Brunet, Grégory Resch, Benoit Guery, Christophe Von Garnier
Author Information
  1. Georgia Mitropoulou: Service de pneumologie, Département de médecine, Centre hospitalier universitaire vaudois et Université de Lausanne, 1011 Lausanne.
  2. Pieter-Jan Gijs: Service de pneumologie, Département de médecine, Centre hospitalier universitaire vaudois et Université de Lausanne, 1011 Lausanne.
  3. Angela Koutsokera: Service de pneumologie, Département de médecine, Centre hospitalier universitaire vaudois et Université de Lausanne, 1011 Lausanne.
  4. Alain Sauty: Service de pneumologie, Département de médecine, Centre hospitalier universitaire vaudois et Université de Lausanne, 1011 Lausanne.
  5. Sylvain Blanchon: Unité de pneumologie et mucoviscidose pédiatrique, Service de pédiatrie, Département femme-mère-enfant, Centre hospitalier universitaire vaudois et Université de Lausanne, 1011 Lausanne.
  6. Chantal Csajka: Centre de recherche et d'innovation en sciences pharmaceutiques cliniques, Centre hospitalier universitaire vaudois, 1011 Lausanne.
  7. Jean-François Brunet: Centre de production cellulaire, Département des centres interdisciplinaires, Centre hospitalier universitaire vaudois, 1011 Lausanne.
  8. Grégory Resch: Centre de recherche et d'innovation en sciences pharmaceutiques cliniques, Centre hospitalier universitaire vaudois, 1011 Lausanne.
  9. Benoit Guery: Service des maladies infectieuses, Département de médecine, Centre hospitalier universitaire vaudois et Université de Lausanne, 1011 Lausanne.
  10. Christophe Von Garnier: Service de pneumologie, Département de médecine, Centre hospitalier universitaire vaudois et Université de Lausanne, 1011 Lausanne.

Abstract

The crisis of antibiotic resistance represents a global public health challenge, affecting particularly patients with respiratory infections. The use of (bacterio)phages for the treatment of bacterial infections (phage therapy) seems safe but its effectiveness has not yet been proven by controlled clinical trials. Nevertheless, phage therapy is regaining interest, encouraged by published cases treated successfully with personalized phage combinations as well as significant advances at a preclinical level. Standardized approaches in phage production and treatment administration, as well as future translational studies, are needed to improve our understanding and explore the potential of phage therapy.

MeSH Term

Humans
Phage Therapy
Bacterial Infections
Bacteriophages
Respiratory Tract Infections
Drug Resistance, Microbial
Anti-Bacterial Agents

Chemicals

Anti-Bacterial Agents

Word Cloud

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