Right Ventricular Dysfunction During Endurance Exercise as Determined by Pressure-Volume Analysis.

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Justin A Edward, Lukasz P Cerbin, Daniel W Groves, Robert A Quaife, Kendall S Hunter, Benjamin D Levine, William K Cornwell

Author Information

Justin A Edward: Department of Medicine-Cardiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Lukasz P Cerbin: Department of Medicine-Cardiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Daniel W Groves: Department of Medicine-Cardiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Robert A Quaife: Department of Medicine-Cardiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Kendall S Hunter: Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Benjamin D Levine: Division of Cardiology, Department of Medicine, University of Texas Southwestern Medical Campus, Dallas, Texas, USA.
William K Cornwell: Department of Medicine-Cardiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

PMID: 36388707 DOI: 10.1016/j.jaccas.2022.08.006

A 37-year-old athlete completed invasive endurance (90 km) bicycle exercise testing for right ventricular pressure-volume analysis. Increased right ventricular afterload caused declines in ventricular-arterial coupling and cardiac output, causing increased arteriovenous oxygen difference to maintain oxygen uptake. These findings demonstrate effects of changes in right ventricular performance on exercise capacity. ().

CMR, cardiac magnetic resonance Ea, effective arterial elastance Ees, end-systolic elastance PA, pulmonary arterial PV, pressure volume Qc, cardiac output RV, right ventricle Vo2 max, maximal oxygen consumption exercise hemodynamics right ventricle sports

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UL1 TR002535/NCATS NIH HHS

Journal Article

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Right ventricular performance during acute hypoxic exercise.Physical exercise for pulmonary arterial hypertension diagnosis and therapy.Clinical Applications of Pressure-Volume Assessment in Congenital Heart Disease.

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