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International journal of hematology
Mar, 2023;117 (3): 421-427.

Severe short-term adverse events in related bone marrow or peripheral blood stem cell donors.

Ryu Yanagisawa, Tsuneaki Hirakawa, Noriko Doki, Kazuhiro Ikegame, Ken-Ichi Matsuoka, Takahiro Fukuda, Hirohisa Nakamae, Shuichi Ota, Nobuhiro Hiramoto, Jun Ishikawa, Takahide Ara, Masatsugu Tanaka, Yuhki Koga, Toshiro Kawakita, Yumiko Maruyama, Yoshinobu Kanda, Masayuki Hino, Yoshiko Atsuta, Hiromasa Yabe, Nobuhiro Tsukada
Author Information
  1. Ryu Yanagisawa: Division of Blood Transfusion, Shinshu University Hospital, 3-1-1, Asahi, Matsumoto, 390-8621, Japan. ryu@shinshu-u.ac.jp. ORCID
  2. Tsuneaki Hirakawa: Department of Hematology, Nippon Medical School, Tokyo, Japan.
  3. Noriko Doki: Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.
  4. Kazuhiro Ikegame: Department of Hematology, Hyogo Medical University Hospital, Nishinomiya, Japan.
  5. Ken-Ichi Matsuoka: Department of Hematology and Oncology, Okayama University Hospital, Okayama, Japan.
  6. Takahiro Fukuda: Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.
  7. Hirohisa Nakamae: Hematology, Osaka Metropolitan University, Osaka, Japan.
  8. Shuichi Ota: Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan.
  9. Nobuhiro Hiramoto: Department of Hematology, Kobe City Medical Center General Hospital, Kobe, Japan.
  10. Jun Ishikawa: Department of Hematology, Osaka International Cancer Institute, Osaka, Japan.
  11. Takahide Ara: Department of Hematology, Hokkaido University Hospital, Sapporo, Japan.
  12. Masatsugu Tanaka: Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan.
  13. Yuhki Koga: Department of Pediatrics, Kyushu University Hospital, Fukuoka, Japan.
  14. Toshiro Kawakita: Department of Hematology, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan.
  15. Yumiko Maruyama: Department of Hematology, University of Tsukuba Hospital, Tsukuba, Japan.
  16. Yoshinobu Kanda: Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan.
  17. Masayuki Hino: Hematology, Osaka Metropolitan University, Osaka, Japan.
  18. Yoshiko Atsuta: Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan.
  19. Hiromasa Yabe: Department of Pediatrics, Tokai University School of Medicine, Isehara, Japan.
  20. Nobuhiro Tsukada: Department of Hematology, Japanese Red Cross Medical Center, Tokyo, Japan.
PMID: 36403180 DOI: 10.1007/s12185-022-03489-4

Abstract

The incidence of severe adverse events (SAEs) and associated risk factors in hematopoietic cell transplantation donors needs to be clarified for related donors (relatives of the transplant recipient), whose criteria for donation are more lenient than for unrelated donors. Data from related donors registered in the Japanese national data registry database between 2005 and 2021 were evaluated to determine the association of short-term SAE incidence with donor characteristics at registration.Fourteen of 4339 bone marrow (BM) donors (0.32%) and 54 of 10,684 peripheral blood stem cell (PBSC) donors (0.51%) experienced confirmed SAEs during the short donation period. No deaths were observed. Past medical history was a common risk factor for SAEs in both BM and PBSC donors. Age of 60 years or older and female sex were identified as risk factors for SAEs in PBSC donors. Female sex was also a risk factor for poor mobilization, which resulted in discontinuation of PBSC collection.Although donors should be selected carefully, a certain level of safety is ensured for related donors in Japan. Donor safety should be further increased by improving the selection method for related donors and extending the follow-up period.

Keywords

BM collection Donor safety Family donors PBSC harvest Poor mobilizer Related donation

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MeSH Term

Humans
Female
Middle Aged
Bone Marrow
Bone Marrow Transplantation
Peripheral Blood Stem Cells
Peripheral Blood Stem Cell Transplantation
Tissue Donors
Unrelated Donors
Blood Donors
Journal Article

Word Cloud

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