Vitamin D in the Treatment of Oral Lichen Planus: A Systematic Review.
Shazina Saeed, Priyadarshini Choudhury, Syed Ansar Ahmad, Tanveer Alam, Rajat Panigrahi, Shahid Aziz, Sultan Mohammed Kaleem, Smita R Priyadarshini, Pradyumna Ku Sahoo, Shamimul Hasan
Author Information
Shazina Saeed: Amity Institute of Public Health, Amity University, Noida 201303, India.
Priyadarshini Choudhury: Nahar Hospital, Bhinmal 343029, India.
Syed Ansar Ahmad: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Jamia Millia Islamia, New Delhi 110025, India.
Tanveer Alam: Department of DDS, College of Dentistry, King Khalid University, Abha 61413, Saudi Arabia.
Rajat Panigrahi: Department of Oral Medicine and Radiology, Institute of Dental Sciences, Siksha 'O' Anusandhan University, Bhubaneswar 751003, India.
Shahid Aziz: Department of Medicine, College of Medicine, King Khalid University, Abha 61413, Saudi Arabia. ORCID
Sultan Mohammed Kaleem: Department of DDS, College of Dentistry, King Khalid University, Abha 61413, Saudi Arabia.
Smita R Priyadarshini: Department of Oral Medicine and Radiology, Institute of Dental Sciences, Siksha 'O' Anusandhan University, Bhubaneswar 751003, India.
Pradyumna Ku Sahoo: Department of Prosthodontics, Institute of Dental Sciences, Siksha 'O' Anusandhan University, Bhubaneswar 751003, India.
Shamimul Hasan: Department of Oral Medicine and Radiology, Faculty of Dentistry, Jamia Millia Islamia, New Delhi 110025, India. ORCID
Oral lichen planus (OLP) is a chronic mucocutaneous condition that affects up to 2% of the general population, and typically presents with long-standing, non-responsive lesions, with episodes of exacerbation and remissions. The etiopathogenesis of OLP is still unclear, although, it has been postulated that it is most likely a T-cell-mediated condition of an unknown antigen. The treatment remains a challenge with no defined treatment strategy. Vitamin D has anti-inflammatory and immunomodulatory properties, along with its regulatory effect on keratinocyte proliferation and differentiation; thus, suggesting its possible role in the treatment of OLP. This systematic review aims to evaluate the therapeutic role of vitamin D in OLP treatment. We searched PubMed/MEDLINE, and Google scholar search engines for studies evaluating vitamin D as a treatment modality in OLP from January 2000 to August 2022. Articles were searched with the combination of Medical Subject Heading (MeSH) terms. A web platform for visualizing risk-of-bias assessment was used in this review, and descriptive statistics were calculated. Out of the seventeen retrieved studies, five articles meeting the inclusion criteria were considered in this systematic review. All the included studies demonstrated significant amelioration in the OLP symptoms in patients who were given vitamin D supplements as an adjuvant to the conventional steroid therapy and or placebo. This systematic review signifies the role of vitamin D as adjuvant therapy for OLP. However, more studies with larger sample size are required to validate these results.
