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Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine
Jan 01, 2024;23 (1): 1-13.

Interstitial Fluidopathy of the Central Nervous System: An Umbrella Term for Disorders with Impaired Neurofluid Dynamics.

Toshiaki Taoka, Rintaro Ito, Rei Nakamichi, Toshiki Nakane, Hisashi Kawai, Shinji Naganawa
Author Information
  1. Toshiaki Taoka: Department of Innovative Biomedical Visualization (iBMV), Nagoya University.
  2. Rintaro Ito: Department of Innovative Biomedical Visualization (iBMV), Nagoya University.
  3. Rei Nakamichi: Department of Radiology, Nagoya University.
  4. Toshiki Nakane: Department of Radiology, Nagoya University.
  5. Hisashi Kawai: Department of Radiology, Aichi Medical University.
  6. Shinji Naganawa: Department of Radiology, Nagoya University.
PMID: 36436975 DOI: 10.2463/mrms.rev.2022-0012

Abstract

Interest in interstitial fluid dynamics has increased since the proposal of the glymphatic system hypothesis. Abnormal dynamics of the interstitial fluid have been pointed out to be an important factor in various pathological statuses. In this article, we propose the concept of central nervous system interstitial fluidopathy as a disease or condition in which abnormal interstitial fluid dynamics is one of the important factors for the development of a pathological condition. We discuss the aspects of interstitial fluidopathy in various diseases, including Alzheimer's disease, Parkinson's disease, normal pressure hydrocephalus, and cerebral small vessel disease. We also discuss a method called "diffusion tensor image analysis along the perivascular space" using MR diffusion images, which is used to evaluate the degree of interstitial fluidopathy or the activity of the glymphatic system.

Keywords

cerebrospinal fluid glymphatic system interstitial fluid dynamics interstitial fluidopathy pathophysiology

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MeSH Term

Humans
Glymphatic System
Alzheimer Disease
Hydrocephalus, Normal Pressure
Parkinson Disease
Hydrodynamics
Brain
Journal Article
Article has an altmetric score of 11

Word Cloud

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