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European journal of applied physiology
Apr, 2023;123 (4): 781-796.

Dynamic resistance exercise-induced pressor response does not alter hypercapnia-induced cerebral vasodilation in young adults.

Rintaro Sakamoto, Kohei Sato, Shigehiko Ogoh, Tatsuki Kamoda, Toru Neki, Masaki Katayose, Erika Iwamoto
Author Information
  1. Rintaro Sakamoto: Graduate School of Health Sciences, Sapporo Medical University, Sapporo, Japan.
  2. Kohei Sato: Graduate School of Health Sciences, Sapporo Medical University, Sapporo, Japan.
  3. Shigehiko Ogoh: Department of Biomedical Engineering, Toyo University, Kawagoe, Japan.
  4. Tatsuki Kamoda: Graduate School of Health Sciences, Sapporo Medical University, Sapporo, Japan.
  5. Toru Neki: Department of Physical Therapy, School of Health Sciences, Sapporo Medical University, Sapporo, Japan.
  6. Masaki Katayose: Department of Physical Therapy, School of Health Sciences, Sapporo Medical University, Sapporo, Japan.
  7. Erika Iwamoto: Department of Physical Therapy, School of Health Sciences, Sapporo Medical University, Sapporo, Japan. e.iwamoto@sapmed.ac.jp. ORCID
PMID: 36454281 DOI: 10.1007/s00421-022-05096-x

Abstract

Excessive arterial pressure elevation induced by resistance exercise (RE) attenuates peripheral vasodilatory function, but its effect on cerebrovascular function is unknown. We aimed to evaluate the effect of different pressor responses to RE on hypercapnia-induced vasodilation of the internal carotid artery (ICA), an index of cerebrovascular function. To manipulate pressor responses to RE, 15 healthy young adults (11M/4F) performed two RE: high intensity with low repetitions (HL) and low intensity with high repetitions (LH) dynamic knee extension. ICA dilation, induced by 3 min of hypercapnia, was measured before and 10 min after RE using Doppler ultrasound. HL exercise elicited a greater pressor response than LH exercise. In relaxation phases of RE, ICA blood velocity increased in both HL and LH trials. However, ICA shear rate did not significantly increase in either trial (P = 0.06). Consequently, neither exercise altered post-exercise hypercapnia-induced ICA dilation (HL, 3.9 ± 1.9% to 5.1 ± 1.7%; LH, 4.6 ± 1.4% to 4.8 ± 1.8%; P > 0.05 for all). When viewed individually, the changes in ICA shear rate were positively correlated with changes in end-tidal partial pressure of carbon dioxide (PCO) (r = 0.46, P < 0.01) than with mean arterial pressure (r = 0.32, P = 0.02). These findings suggest that the effects of RE-induced pressor response on cerebrovascular function may be different from peripheral arteries. An increase in PCO during the relaxation phase may play a more crucial role than elevated pressure in increasing cerebral shear during dynamic RE.

Keywords

Dynamic resistance exercise Hypercapnia-induced cerebral vasodilation Internal carotid artery Pressor response

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Grants

  1. 21J22042/Japanese Ministry of Education, Culture, Sports, Science and Technology
  2. 20K11186/Japanese Ministry of Education, Culture, Sports, Science and Technology

MeSH Term

Humans
Young Adult
Hypercapnia
Carbon Dioxide
Carotid Artery, Internal
Vasodilation
Resistance Training
Cerebrovascular Circulation
Blood Flow Velocity

Chemicals

Carbon Dioxide
Journal Article
Article has an altmetric score of 1

Word Cloud

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