Steps toward nebulization in-use studies to understand the stability of new biological entities.

Carlos Victor Montefusco-Pereira
Author Information
  1. Carlos Victor Montefusco-Pereira: Independent Researcher. Electronic address: cmontefusco@gmail.com.

Abstract

The need for novel biological drugs against respiratory diseases has been highlighted during the Coronavirus (COVID-19) pandemic. The use of inhalation presents challenges to drug product stability, which is especially true for delivery using nebulizers (jet versus mesh technologies). The late-stage process of drug development in the pharmaceutical industry requires the investigation of in-use stability. In-use studies generate data that are guided by the requirements of regulatory authorities for inclusion in the clinical trial application dossier. In this review, I introduce the initial aspects of in-use stability studies during the development of an aerosol formulation to deliver biologics with a nebulizer. Lessons learned from this experience can guide future development and planning for formulation, analytics, material compatibility, nebulization process, and clinical trial preparations.

Keywords

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MeSH Term

Humans
Drug Delivery Systems
COVID-19
Respiratory Aerosols and Droplets
Nebulizers and Vaporizers
Administration, Inhalation
Equipment Design

Word Cloud

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