OpenLB
Open Library of Bioscience
Advanced Search
Advances in experimental medicine and biology
2022;1391 97-117.

A Perspective on Reproductive Toxicity of Metallic Nanomaterials.

Usha Singh Gaharwar, Sonali Pardhiya, Paulraj Rajamani
Author Information
  1. Usha Singh Gaharwar: School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, India.
  2. Sonali Pardhiya: School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, India.
  3. Paulraj Rajamani: School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, India. paulrajr@yahoo.com.
PMID: 36472819 DOI: 10.1007/978-3-031-12966-7_7

Abstract

Nanotechnological tools have been greatly exploited in all possible fields. However, advancement of nanotechnology has raised concern about their adverse effects on human and environment. These deleterious effects cannot be ignored and need to be explored due to safety purpose. Several recent studies have demonstrated possible health hazard of nanoparticles on organism. Moreover, studies showed that toxicity of metallic nanomaterial could also lead to reproductive toxicity. Various deleterious effects have demonstrated decreased sperm motility, increased abnormal spermatozoa, altered sperm count, and altered sperm morphology. Morphological and ultrastructural changes also have been reported due to the accumulation of these nanomaterials in reproductive organs. Nonetheless, studies also suggest crossing of metallic nanoparticles through blood testes barrier and generation of oxidative stress which plays major role in reproductive toxicity. In the present study, we have incorporated updated information by gathering all available literature about various metallic nanomaterials and risk related to reproductive system.

Keywords

Fertility Gold nanoparticles Histopathological changes Iron oxide nanoparticles Reactive oxygen species Teratogenicity

References

  1. Agarwal R, Barrelet CJ, Lieber CM. Lasing in single cadmium sulfide nanowire optical cavities. Nano Lett. 2005;5(5):917–20. [DOI: 10.1021/nl050440u]
  2. Ahmadian E, Dizaj SM, Rahimpour E, Hasanzadeh A, Eftekhari A, Halajzadeh J, Ahmadian H. Effect of silver nanoparticles in the induction of apoptosis on human hepatocellular carcinoma (HepG2) cell line. Mater Sci Eng C. 2018;93:465–71. [DOI: 10.1016/j.msec.2018.08.027]
  3. Alexander JW. History of the medical use of silver. Surg Infect. 2009;10(3):289–92. [DOI: 10.1089/sur.2008.9941]
  4. Al-Sheddi ES, Farshori NN, Al-Oqail MM, Al-Massarani SM, Saquib Q, Wahab R, et al. Anticancer potential of green synthesized silver nanoparticles using extract of Nepeta deflersiana against human cervical cancer cells (HeLA). Bioinorg Chem Appl. 2018;2018:9390784. [DOI: 10.1155/2018/9390784]
  5. Ali N, Amiri BA, Melika G. The effect of titanium dioxide nanoparticles injection in neonatal period on ovaries in mature rats. GSC Biol. Pharm. Sci. 2019;6(1).
  6. Anderson K, Poulter B, Dudgeon J, Li SE, Ma X. A highly sensitive nonenzymatic glucose biosensor based on the regulatory effect of glucose on electrochemical behaviors of colloidal silver nanoparticles on MoS2. Sensors. 2017;17(8):1807. [DOI: 10.3390/s17081807]
  7. Asgary V, Shoari A, Baghbani-Arani F, Shandiz SAS, Khosravy MS, Janani A, et al. Green synthesis and evaluation of silver nanoparticles as adjuvant in rabies veterinary vaccine. Int J Nanomed. 2016;11:3597. [DOI: 10.2147/IJN.S109098]
  8. Asharani PV, Lianwu YI, Gong Z, Valiyaveettil S. Comparison of the toxicity of silver, gold and platinum nanoparticles in developing zebrafish embryos. Nanotoxicology. 2011;5(1):43–54. [DOI: 10.3109/17435390.2010.489207]
  9. Azenabor A, Ekun AO, Akinloye O. Impact of inflammation on male reproductive tract. J Reprod Infertil. 2015;16:123.
  10. Bailly AL, Correard F, Popov A, Tselikov G, Chaspoul F, Appay R, et al. In vivo evaluation of safety, biodistribution and pharmacokinetics of laser-synthesized gold nanoparticles. Sci Rep. 2019;9(1):1–12. [DOI: 10.1038/s41598-019-48748-3]
  11. Bajaj VK, Goyal A, Sharma G, Sharma KB, Gupta RS. Synthesis of CdS nanoparticle and reveal its effect on reproductive system of male albino rats. BioNanoScience. 2013;3(1):58–66. [DOI: 10.1007/s12668-012-0068-z]
  12. Bakare AA, Udoakang AJ, Anifowoshe AT, Fadoju OM, Ogunsuyi OI, Alabi OA, Alimba CG, Oyeyemi IT. Genotoxicity of titanium dioxide nanoparticles using the mouse bone marrow micronucleus and sperm morphology assays. J Pollut Eff. Control. 2016;7:1–7.
  13. Baki ME, Miresmaili SM, Pourentezari M, Amraii E, Yousefi V, Spenani HR, et al. Effects of silver nano-particles on sperm parameters, number of Leydig cells and sex hormones in rats. Iran J Reprod Med. 2014;12(2):139.
  14. Bar-Ilan O, Albrecht RM, Fako VE, Furgeson DY. Toxicity assessments of multisized gold and silver nanoparticles in zebrafish embryos. Small. 2009;5(16):1897–910. [DOI: 10.1002/smll.200801716]
  15. Barillo DJ, Marx DE. Silver in medicine: a brief history BC 335 to present. Burns. 2014;40:S3–8. [DOI: 10.1016/j.burns.2014.09.009]
  16. Behnammorshedi M, Nazem H. The effect of gold nanoparticle on luteinizing hormone, follicle stimulating hormone, testosterone and testis in male rat. Biomed Res. 2015;26(2):348–52.
  17. Besov AS, Krivova NA, Vorontsov AV, Zaeva OB, Kozlov DV, Vorozhtsov AB, Parmon VN, Sakovich GV, Komarov VF, Smirniotis PG, Eisenreich N. Air detoxification with nanosize TiO aerosol tested on mice. J Hazard Mater. 2010;173(1–3):40–6.
  18. Bisht S, Faiq M, Tolahunase M, Dada R. Oxidative stress and male infertility. Nat Rev Urol. 2017;14:470–85. [DOI: 10.1038/nrurol.2017.69]
  19. Blum JL, Xiong JQ, Hoffman C, Zelikoff JT. Cadmium associated with inhaled cadmium oxide nanoparticles impacts fetal and neonatal development and growth. Toxicol Sci. 2012;126(2):478–86. [DOI: 10.1093/toxsci/kfs008]
  20. Balmuri SR, Selvaraj U, Kumar VV, Anthony SP, Tsatsakis AM, Golokhvast KS, Raman T. Effect of surfactant in mitigating cadmium oxide nanoparticle toxicity: implications for mitigating cadmium toxicity in environment. Environ Res. 2017;152:141–9.
  21. Bowers MJ, McBride JR, Rosenthal SJ. White-light emission from magic-sized cadmium selenide nanocrystals. J Am Chem Soc. 2005;127(44):15378–9. [DOI: 10.1021/ja055470d]
  22. Browning LM, Lee KJ, Huang T, Nallathamby PD, Lowman JE, Xu XH. Random walk of single gold nanoparticles in zebrafish embryos leading to stochastic toxic effects on embryonic developments. Nanoscale. 2009;1(1):138–52.
  23. Burygin GL, Khlebtsov BN, Shantrokha AN, Dykman LA, Bogatyrev VA, Khlebtsov NG. On the enhanced antibacterial activity of antibiotics mixed with gold nanoparticles. Nanoscale Res Lett. 2009;4(8):794–801. [DOI: 10.1007/s11671-009-9316-8]
  24. Campagnolo L, Massimiani M, Magrini A, Camaioni A, Pietroiusti A. Physico-chemical properties mediating reproductive and developmental toxicity of engineered nanomaterials. Curr Med Chem. 2012;19(26):4488–94. [DOI: 10.2174/092986712803251566]
  25. Chan WH, Shiao NH. Cytotoxic effect of CdSe quantum dots on mouse embryonic development. Acta Pharmacol Sin. 2008;29(2):259–66. [DOI: 10.1111/j.1745-7254.2008.00743.x]
  26. Chen H, Dorrigan A, Saad S, Hare DJ, Cortie MB, Valenzuela SM. In vivo study of spherical gold nanoparticles: inflammatory effects and distribution in mice. PLoS One. 2013;8(2):e58208. [DOI: 10.1371/journal.pone.0058208]
  27. Chen SX, Yang XZ, Deng Y, Huang J, Li Y, Sun Q, et al. Silver nanoparticles induce oocyte maturation in zebrafish (Danio rerio). Chemosphere. 2017;170:51–60. [DOI: 10.1016/j.chemosphere.2016.12.016]
  28. Choi H, Stathatos E, Dionysiou DD. Sol–gel preparation of mesoporous photocatalytic TiO2 films and TiO2/Al2O3 composite membranes for environmental applications. Applied Catalysis B: Environmental. 2006;63(1–2):60–7.
  29. Chu M, Wu Q, Yang H, Yuan R, Hou S, Yang Y, et al. Transfer of quantum dots from pregnant mice to pups across the placental barrier. Small. 2010;6(5):670–8. [DOI: 10.1002/smll.200902049]
  30. Das J, Choi YJ, Song H, Kim JH. Potential toxicity of engineered nanoparticles in mammalian germ cells and developing embryos: treatment strategies and anticipated applications of nanoparticles in gene delivery. Hum Reprod. 2016;22:588–619.
  31. Dayal N, Singh D, Patil P, Thakur M, Vanage G, Joshi DS. Effect of bioaccumulation of gold nanoparticles on ovarian morphology of female zebrafish (Danio rerio). World J Pathol. 2017;6(1).
  32. de Brito JLM, Lima VND, Ansa DO, Moya SE, Morais PC, Azevedo RBD, Lucci CM. Acute reproductive toxicology after intratesticular injection of silver nanoparticles (AgNPs) in Wistar rats. Nanotoxicology. 2020;14(7):893–907. [DOI: 10.1080/17435390.2020.1774812]
  33. De La Cruz GG, Gomez-Cansino R, Rodriguez-Fragoso P, Jaimeschavez P, Barbosa-Rayo AL, Reyes-Esparza J, Rodriguez-Fragoso L. Disposition and biocompatibility of dextrin-coated cadmium sulphide nanoparticles after a single dose and multiple doses in rats. Indian J Pharm Sci. 2019;81(5):876–84.
  34. Deng QF, Ren TZ, Yuan ZY. Mesoporous manganese oxide nanoparticles for the catalytic total oxidation of toluene. React Kinet Mech Catal. 2013;108(2):507–18. [DOI: 10.1007/s11144-012-0528-z]
  35. Dziendzikowska K, Krawczyńska A, Oczkowski M, Królikowski T, Brzóska K, Lankoff A, Gromadzka-Ostrowska J. Progressive effects of silver nanoparticles on hormonal regulation of reproduction in male rats. Toxicol Appl Pharmacol. 2016;313:35–46. [DOI: 10.1016/j.taap.2016.10.013]
  36. El-Deab MS, Ohsaka T. Manganese oxide nanoparticles electrodeposited on platinum are superior to platinum for oxygen reduction. Angew Chem Int Ed. 2006;45(36):5963–6. [DOI: 10.1002/anie.200600692]
  37. Elder A, Gelein R, Silva V, Feikert T, Opanashuk L, Carter J, Oberdörster G. Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Environ Health Perspect. 2006;114(8):1172–8. [DOI: 10.1289/ehp.9030]
  38. El-Sayed YS, Shimizu R, Onoda A, Takeda K, Umezawa M. Carbon black nanoparticle exposure during middle and late fetal development induces immune activation in male offspring mice. Toxicology. 2015;327:53–61. [DOI: 10.1016/j.tox.2014.11.005]
  39. Ema M, Kobayashi N, Naya M, Hanai S, Nakanishi J. Reproductive and developmental toxicity studies of manufactured nanomaterials. Reprod Toxicol. 2010;30(3):343–52. [DOI: 10.1016/j.reprotox.2010.06.002]
  40. Ema M, Hougaard KS, Kishimoto A, Honda K. Reproductive and developmental toxicity of carbon-based nanomaterials: a literature review. Nanotoxicology. 2016;10:391–412. [DOI: 10.3109/17435390.2015.1073811]
  41. Erikson KM, Aschner M. Manganese neurotoxicity and glutamate-GABA interaction. Neurochem Int. 2003;43(4–5):475–80. [DOI: 10.1016/S0197-0186(03)00037-8]
  42. Estelrich J, Sánchez-Martín MJ, Busquets MA. Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents. Int J Nanomedicine. 2015;10:1727.
  43. Fard NN, Noorbazargan H, Mirzaie A, Hedayati C, M., Moghimiyan, Z., & Rahimi, A. Biogenic synthesis of AgNPs using Artemisia oliveriana extract and their biological activities for an effective treatment of lung cancer. Artif Cells Nanomed Biotechnol. 2018;46(sup3):S1047–58. [DOI: 10.1080/21691401.2018.1528983]
  44. Fathi N, Hoseinipanah SM, Alizadeh Z, Assari MJ, Moghimbeigi A, Mortazavi M, et al. The effect of silver nanoparticles on the reproductive system of adult male rats: a morphological, histological and DNA integrity study. Adv Clin Exp Med. 2019;28(3):299–305. [DOI: 10.17219/acem/81607]
  45. Fraga S, Brandão A, Soares ME, Morais T, Duarte JA, Pereira L, et al. Short-and long-term distribution and toxicity of gold nanoparticles in the rat after a single-dose intravenous administration. Nanomedicine. 2014;10(8):1757–66. [DOI: 10.1016/j.nano.2014.06.005]
  46. Fredericks J, Senapati S, Wannemuehler MJ. Cytotoxic effects of manganese oxide nanoparticles in combination with microbial components on intestinal epithelial cells. F1000Research. 2020;9(975):975. [DOI: 10.12688/f1000research.25238.1]
  47. Frey NA, Peng S, Cheng K, Sun S. Magnetic nanoparticles: synthesis, functionalization, and applications in bioimaging and magnetic energy storage. Chem Soc Rev. 2009;38(9):2532–42. [DOI: 10.1039/b815548h]
  48. Gaharwar US, Meena R, Rajamani P. Biodistribution, clearance and morphological alterations of intravenously administered iron oxide nanoparticles in male wistar rats. Int J Nanomedicine. 2019;14:9677–9692. https://doi.org/10.2147/IJN.S223142 .
  49. Gao G, Ze Y, Li B, Zhao X, Zhang T, Sheng L, Hu R, Gui S, Sang X, Sun Q, Cheng J. Ovarian dysfunction and gene-expressed characteristics of female mice caused by long-term exposure to titanium dioxide nanoparticles. J Hazard Mater. 2012;243:19–27.
  50. Gao G, Ze Y, Zhao X, Sang X, Zheng L, Ze X, Gui S, Sheng L, Sun Q, Hong J, Yu X. Titanium dioxide nanoparticle-induced testicular damage, spermatogenesis suppression, and gene expression alterations in male mice. J Hazard Mater. 2013;258:133–43.
  51. Gao M, Yang Y, Lv M, Song W, Song Z. Oxidative stress and DNA damage in zebrafish liver due to hydroxyapatite nanoparticles-loaded cadmium. Chemosphere. 2018;202:498–505. [DOI: 10.1016/j.chemosphere.2018.03.146]
  52. Geraets L, Oomen AG, Schroeter JD, Coleman VA, Cassee FR. Tissue distribution of inhaled micro-and nano-sized cerium oxide particles in rats: results from a 28-day exposure study. Toxicol Sci. 2012;127(2):463–73. [DOI: 10.1093/toxsci/kfs113]
  53. Gupta H, Singh D, Vanage G, Joshi DS, Thakur M. Evaluation of histopathological and ultrastructural changes in the testicular cells of Wistar rats post chronic exposure to gold nanoparticles. 2018;17:9–15.
  54. Gurunathan S, Park JH, Han JW, Kim JH. Comparative assessment of the apoptotic potential of silver nanoparticles synthesized by Bacillus tequilensis and Calocybe indica in MDA-MB-231 human breast cancer cells: targeting p53 for anticancer therapy. Int J Nanomedicine. 2015;10:4203. [DOI: 10.2147/IJN.S83953]
  55. Gurunathan S, Qasim M, Park C, Yoo H, Kim JH, Hong K. Cytotoxic potential and molecular pathway analysis of silver nanoparticles in human colon cancer cells HCT116. Int J Mol Sci. 2018;19(8):2269. [DOI: 10.3390/ijms19082269]
  56. Han JW, Jeong JK, Gurunathan S, Choi YJ, Das J, Kwon DN, Cho SG, Park C, Seo HG, Park JK, et al. Maleand female-derived somatic and germ cell-specific toxicity of silver nanoparticles in mouse. Nanotoxicology. 2016;10:361–73. [DOI: 10.3109/17435390.2015.1073396]
  57. Haneefa M, Jayandran M, Balasubramanian M. Evaluation of antimicrobial activity of green-synthesized manganese oxide nanoparticles and comparative studies with curcuminaniline functionalized nanoform. Asian J Pharm Clin Res. 2017;10(3):347–52. [DOI: 10.22159/ajpcr.2017.v10i3.16246]
  58. Haque MM, Im HY, Seo JE, Hasan M, Woo K, Kwon OS. Acute toxicity and tissue distribution of CdSe/CdS-MPA quantum dots after repeated intraperitoneal injection to mice. J Appl Toxicol. 2013;33(9):940–50. [DOI: 10.1002/jat.2775]
  59. Horvath E, Oszlánczi G, Máté Z, Szabó A, Kozma G, Sápi A, et al. Nervous system effects of dissolved and nanoparticulate cadmium in rats in subacute exposure. J Appl Toxicol. 2011;31(5):471–6. [DOI: 10.1002/jat.1664]
  60. Hougaard KS, Campagnolo L, Chavatte-Palmer P, Tarrade A, Rousseau-Ralliard D, Valentino S, Park MV, de Jong WH, Wolterink G, Piersma AH, Ross BL, Hutchison GR, Hansen JS, Vogel U, Jackson P, Slama R, Pietroiusti A, Cassee FR. A perspective on the developmental toxicity of inhaled nanoparticles. Reprod Toxicol. 2015;56:118–40. [DOI: 10.1016/j.reprotox.2015.05.015]
  61. Hoyt VW, Mason E. Nanotechnology: emerging health issues. J Chem Health Saf. 2008;15:10–5. [DOI: 10.1016/j.jchas.2007.07.015]
  62. Hsieh MS, Shiao NH, Chan WH. Cytotoxic effects of CdSe quantum dots on maturation of mouse oocytes, fertilization, and fetal development. Int J Mol Sci. 2009;10(5):2122–35. [DOI: 10.3390/ijms10052122]
  63. Hu R, Gong X, Duan Y, Li N, Che Y, Cui Y, Zhou M, Liu C, Wang H, Hong F. Neurotoxicological effects and the impairment of spatial recognition memory in mice caused by exposure to TiO nanoparticles. Biomaterials. 2010;31(31):8043–50.
  64. Hussain SM, Hess KL, Gearhart JM, Geiss KT, Schlager JJ. In vitro toxicity of nanoparticles in BRL 3A rat liver cells. Toxicol In Vitro. 2005;19(7):975–83. [DOI: 10.1016/j.tiv.2005.06.034]
  65. Jia YP, Ma BY, Wei XW, Qian ZY. The in vitro and in vivo toxicity of gold nanoparticles. Chin Chem Lett. 2017;28(4):691–702. [DOI: 10.1016/j.cclet.2017.01.021]
  66. Kadar E, Dyson O, Handy RD, Al-Subiai SN. Are reproduction impairments of free spawning marine invertebrates exposed to zero-valent nano-iron associated with dissolution of nanoparticles? Nanotoxicology. 2013;7(2):135–43. [DOI: 10.3109/17435390.2011.647927]
  67. Kaiser JP, Zuin S, Wick P. Is nanotechnology revolutionizing the paint and lacquer industry? A critical opinion. Science of the Total Environment. 2013;442:282–9.
  68. Kalynovskyi VY, Pustovalov AS, Grodzyuk GY, Andriushyna NS, Dzerzhynsky ME. Effect of gold and silver nanoparticles on the morpho-functional state of the epididymis and prostate gland in rats. Regul Mech Biosyst. 2016;7(2):106–11.
  69. Karmakar A, Zhang Q, Zhang Y. Neurotoxicity of nanoscale materials. J Food Drug Anal. 2014;22(1):147–60. [DOI: 10.1016/j.jfda.2014.01.012]
  70. Kirchner C, Liedl T, Kudera S, Pellegrino T, Muñoz Javier A, Gaub HE, et al. Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles. Nano Lett. 2005;5(2):331–8. [DOI: 10.1021/nl047996m]
  71. Kovács D, Igaz N, Keskeny C, Bélteky P, Tóth T, Gáspár R, et al. Silver nanoparticles defeat p53-positive and p53-negative osteosarcoma cells by triggering mitochondrial stress and apoptosis. Sci Rep. 2016;6(1):1–13. [DOI: 10.1038/srep27902]
  72. Krystek P, Tentschert J, Nia Y, Trouiller B, Noël L, Goetz ME, … & De Jong WH. Method development and inter-laboratory comparison about the determination of titanium from titanium dioxide nanoparticles in tissues by inductively coupled plasma mass spectrometry. Anal Bioanal Chem. 2014;406(16), 3853–3861.
  73. Kumar SD, Singaravelu G, Ajithkumar S, Murugan K, Nicoletti M, Benelli G. Mangrove-mediated green synthesis of silver nanoparticles with high HIV-1 reverse transcriptase inhibitory potential. J Clust Sci. 2017;28(1):359–67. [DOI: 10.1007/s10876-016-1100-1]
  74. Kumara BP, Karikkatb S, Krishna SH, Udayashankarab TH, Shivaprasada KH, Nagabhushanac BM. Synthesis, characterization of nano MnO2 and its adsorption characteristics over an azo dye. J Mater Sci. 2014;2(1):27–31.
  75. Lafuente D, Garcia T, Blanco J, Sánchez DJ, Sirvent JJ, Domingo JL, Gómez M. Effects of oral exposure to silver nanoparticles on the sperm of rats. Reprod Toxicol. 2016;60:133–9. [DOI: 10.1016/j.reprotox.2016.02.007]
  76. Lan Z, Yang WX. Nanoparticles and spermatogenesis: how do nanoparticles affect spermatogenesis and penetrate the blood–testis barrier. Nanomedicine. 2012;7:579–96. [DOI: 10.2217/nnm.12.20]
  77. Lansdown AB. Silver in health care: antimicrobial effects and safety in use. Biofunct Text Skin. 2006;33:17–34. [DOI: 10.1159/000093928]
  78. Leclerc L, Klein JP, Forest V, Boudard D, Martini M, Pourchez J, et al. Testicular biodistribution of silica-gold nanoparticles after intramuscular injection in mice. Biomed Microdevices. 2015;17(4):1–11. [DOI: 10.1007/s10544-015-9968-3]
  79. Lee J, Jeong JS, Kim SY, Park MK, Choi SD, Kim UJ, Park K, Jeong EJ, Nam SY, Yu WJ. Titanium dioxide nanoparticles oral exposure to pregnant rats and its distribution. Part Fibre Toxicol. 2019;16(1):1–12.
  80. Li WN, Yuan J, Shen XF, Gomez-Mower S, Xu LP, Sithambaram S, et al. hydrothermal synthesis of structure-and shape-controlled manganese oxide octahedral molecular sieve nanomaterials. Adv Funct Mater. 2006;16(9):1247–53. [DOI: 10.1002/adfm.200500504]
  81. Li KG, Chen JT, Bai SS, Wen X, Song SY, Yu Q, et al. Intracellular oxidative stress and cadmium ions release induce cytotoxicity of unmodified cadmium sulfide quantum dots. Toxicol In Vitro. 2009;23(6):1007–13. [DOI: 10.1016/j.tiv.2009.06.020]
  82. Liu S, Krewski D, Shi Y, Chen Y, Burnett RT. Association between maternal exposure to ambient air pollutants during pregnancy and fetal growth restriction. J Expo Sci Environ Epidemiol. 2007;17(5):426–32. [DOI: 10.1038/sj.jes.7500503]
  83. Liu L, Sun M, Li Q, Zhang H, Alvarez PJ, Liu H, Chen W. Genotoxicity and cytotoxicity of cadmium sulfide nanomaterials to mice: comparison between nanorods and nanodots. Environ Eng Sci. 2014;31(7):373–80. [DOI: 10.1089/ees.2013.0417]
  84. Liu Y, Li X, Xiao S, Liu X, Chen X, Xia Q, et al. The effects of gold nanoparticles on Leydig cells and male reproductive function in mice. Int J Nanomed. 2020;15:9499. [DOI: 10.2147/IJN.S276606]
  85. Lytvynenko A, Rieznichenko L, Sribna V, Stupchuk M, Grushka N, Shepel A, et al. Functional status of reproductive system under treatment of silver nanoparticles in female mice. Int J Reprod Contracept Obstet Gynecol. 2017;6(5):1713–20. [DOI: 10.18203/2320-1770.ijrcog20171930]
  86. Ma L, Liu J, Li N, Wang J, Duan Y, Yan J, Liu H, Wang H, Hong F. Oxidative stress in the brain of mice caused by translocated nanoparticulate TiO2 delivered to the abdominal cavity. Biomaterials. 2010;31(1):99–105.
  87. Ma X, Wu Y, Jin S, Tian Y, Zhang X, Zhao Y, et al. Gold nanoparticles induce autophagosome accumulation through size-dependent nanoparticle uptake and lysosome impairment. ACS Nano. 2011;5(11):8629–39. [DOI: 10.1021/nn202155y]
  88. Ma YB, Lu CJ, Junaid M, Jia PP, Yang L, Zhang JH, Pei DS. Potential adverse outcome pathway (AOP) of silver nanoparticles mediated reproductive toxicity in zebrafish. Chemosphere. 2018;207:320–8. [DOI: 10.1016/j.chemosphere.2018.05.019]
  89. Máté Z, Horváth E, Kozma G, Simon T, Kónya Z, Paulik E, et al. Size-dependent toxicity differences of intratracheally instilled manganese oxide nanoparticles: conclusions of a subacute animal experiment. Biol Trace Elem Res. 2016;171(1):156–66. [DOI: 10.1007/s12011-015-0508-z]
  90. Meena R, Kajal K, Paulraj R. Cytotoxic and genotoxic effects of titanium dioxide nanoparticles in testicular cells of male wistar rat. Appl Biochem Biotechnol. 2014;75(2):825–40. [DOI: 10.1007/s12010-014-1299-y]
  91. Miura N, Ohtani K, Hasegawa T, Yoshioka H, Hwang GW. Biphasic adverse effect of titanium nanoparticles on testicular function in mice. Sci Rep. 2019;9(1):1–8.
  92. Miyamoto Y, Kuroda Y, Uematsu T, Oshikawa H, Shibata N, Ikuhara Y, et al. Synthesis of ultrasmall Li–Mn spinel oxides exhibiting unusual ion exchange, electrochemical and catalytic properties. Sci Rep. 2015;5(1):1–13. [DOI: 10.1038/srep15011]
  93. Morgan AM, Ibrahim MA, Noshy PA. Reproductive toxicity provoked by titanium dioxide nanoparticles and the ameliorative role of Tiron in adult male rats. Biochemical and biophysical research communications. 2017;486(2):595–600.
  94. Mozafari M, Khoradmehr A, Danafar A, Miresmaeili M, Kalantar SM. Toxic effects of maternal exposure to silver nanoparticles on mice fetal development during pregnancy. Birth Defects Res. 2020;112(1):81–92. [DOI: 10.1002/bdr2.1605]
  95. Myllynen PK, Loughran MJ, Howard CV, Sormunen R, Walsh AA, Vähäkangas KH. Kinetics of gold nanoparticles in the human placenta. Reprod Toxicol. 2008;26(2):130–7. [DOI: 10.1016/j.reprotox.2008.06.008]
  96. Nazar M, Talebi AR, Sharifabad MH, Abbasi A, Khoradmehr A, Danafar AH. Acute and chronic effects of gold nanoparticles on sperm parameters and chromatin structure in mice. Int J Reprod BioMed. 2016;14(10):637. [DOI: 10.29252/ijrm.14.10.637]
  97. Negahdary M, Arefian Z, Dastjerdi HA, Ajdary M. Toxic effects of Mn2O3 nanoparticles on rat testis and sex hormone. J Nat Sci Biol Med. 2015;6(2):335. [DOI: 10.4103/0976-9668.159998]
  98. Ng CT, Dheen ST, Yip WCG, Ong CN, Bay BH, Yung LYL. The induction of epigenetic regulation of PROS1 gene in lung fibroblasts by gold nanoparticles and implications for potential lung injury. Biomaterials. 2011;32(30):7609–15. [DOI: 10.1016/j.biomaterials.2011.06.038]
  99. Nirmal M, Dabbousi BO, Bawendi MG, Macklin JJ, Trautman JK, Harris TD, Brus LE. Fluorescence intermittency in single cadmium selenide nanocrystals. Nature. 1996;383(6603):802–4. [DOI: 10.1038/383802a0]
  100. Normandin L, Hazell AS. Manganese neurotoxicity: an update of pathophysiologic mechanisms. Metab Brain Dis. 2002;17(4):375–87. [DOI: 10.1023/A]
  101. Oberdorster G, Oberdorster E, Oberdorster J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect. 2005;113:823–39. [DOI: 10.1289/ehp.7339]
  102. Oei JD, Zhao WW, Chu L, DeSilva MN, Ghimire A, Rawls HR, Whang K. Antimicrobial acrylic materials with in situ generated silver nanoparticles. J Biomed Mater Res B Appl Biomater. 2012;100(2):409–15. [DOI: 10.1002/jbm.b.31963]
  103. Ong C, Lee QY, Cai Y, Liu X, Ding J, Yung LYL, et al. Silver nanoparticles disrupt germline stem cell maintenance in the Drosophila testis. Sci Rep. 2016;6(1):1–10. [DOI: 10.1038/srep20632]
  104. Opris R, Toma V, Olteanu D, Baldea I, Baciu AM, Lucaci FI, Berghian-Sevastre A, Tatomir C, Moldovan B, Clichici S, et al. Effects of silver nanoparticles functionalized with Cornus mas L. extract on architecture and apoptosis in rat testicle. Nanomedicine. 2019;14:275–99. [DOI: 10.2217/nnm-2018-0193]
  105. Pardhiya S, Gaharwar US, Gautam R, Priyadarshini E, Nirala JP, Rajamani P. Cumulative effects of manganese nanoparticle and radiofrequency radiation in male Wistar rats. Drug Chem Toxicol. 2020:1–13.
  106. Paredes D, Ortiz C, Torres R. Synthesis, characterization, and evaluation of antibacterial effect of Ag nanoparticles against Escherichia coli O157: H7 and methicillin-resistant Staphylococcus aureus (MRSA). Int J Nanomedicine. 2014;9:1717.
  107. Pawar K, Kaul G. Toxicity of titanium oxide nanoparticles causes functionality and DNA damage in buffalo (Bubalus bubalis) sperm in vitro. Toxicol Ind Health. 2014;30(6):520–33.
  108. Poley M, Shammai Y, Kaduri M, Koren L, Adir O, Shklover J, et al. Chemotherapeutic nanoparticles accumulate in the female reproductive system during ovulation affecting fertility and anticancer activity. bioRxiv. 2020.
  109. Qin F, Shen T, Li J, Qian J, Zhang J, Zhou G, Tong J. SF-1 mediates reproductive toxicity induced by Cerium oxide nanoparticles in male mice. J Nanobiotechnol. 2019;17(1):41. [DOI: 10.1186/s12951-019-0474-2]
  110. Rattanapinyopituk K, Shimada A, Morita T, Sakurai M, Asano A, Hasegawa T, et al. Demonstration of the clathrin-and caveolin-mediated endocytosis at the maternal–fetal barrier in mouse placenta after intravenous administration of gold nanoparticles. J Vet Med Sci. 2013:13-0512.
  111. Rónavári A, Igaz N, Gopisetty MK, Szerencsés B, Kovács D, Papp C, et al. Biosynthesized silver and gold nanoparticles are potent antimycotics against opportunistic pathogenic yeasts and dermatophytes. Int J Nanomed. 2018;13:695. [DOI: 10.2147/IJN.S152010]
  112. Roy R, Kumar S, Tripathi A, Das M, Dwivedi PD. Interactive threats of nanoparticles to the biological system. Immunol Lett. 2014;158(1–2):79–87. [DOI: 10.1016/j.imlet.2013.11.019]
  113. Salomoni R, Léo P, Rodrigues MFA. Antibacterial activity of silver nanoparticles (AgNPs) in Staphylococcus aureus and cytotoxicity effect in mammalian cells. SubStance. 2015;17:18.
  114. Salomoni R, Léo P, Montemor AF, Rinaldi BG, Rodrigues MFA. Antibacterial effect of silver nanoparticles in Pseudomonas aeruginosa. Nanotechnol Sci Appl. 2017;10:115. [DOI: 10.2147/NSA.S133415]
  115. Saratale GD, Saratale RG, Benelli G, Kumar G, Pugazhendhi A, Kim DS, Shin HS. Anti-diabetic potential of silver nanoparticles synthesized with Argyreia nervosa leaf extract high synergistic antibacterial activity with standard antibiotics against foodborne bacteria. J Clust Sci. 2017;28(3):1709–27. [DOI: 10.1007/s10876-017-1179-z]
  116. Sárközi L, Horváth E, Kónya Z, Kiricsi I, Szalay B, Vezér T, Papp A. Subacute intratracheal exposure of rats to manganese nanoparticles: behavioral, electrophysiological, and general toxicological effects. Inhal Toxicol. 2009;21:83–91. [DOI: 10.1080/08958370902939406]
  117. Selvaraj V, Grace AN, Alagar M, Hamerton I. Antimicrobial and anticancer efficacy of antineoplastic agent capped gold nanoparticles. J Biomed Nanotechnol. 2010;6(2):129–37. [DOI: 10.1166/jbn.2010.1115]
  118. Semmler-Behnke M, Fertsch S, Schmid G, Wenk A, Kreyling WG. Uptake of 1.4 nm versus 18 nm gold nanoparticles in secondary target organs is size dependent in control and pregnant rats after intratracheal or intravenous application. In: Proceedings of the EuroNanoForum; 2007. p. 19–21.
  119. Shehata AM, Salem FM, El-Saied EM, Abd El-Rahman SS, Mahmoud MY, Noshy PA. Zinc nanoparticles ameliorate the reproductive toxicity induced by silver nanoparticles in male rats. Int J Nanomedicine. 2021;16:2555. [DOI: 10.2147/IJN.S307189]
  120. Shi H, Magaye R, Castranova V, Zhao J. Titanium dioxide nanoparticles: a review of current toxicological data. Particle and fibre toxicology. 2013;(1):1–33.
  121. Shittu OK, Aaron SY, Oladuntoye MD, Lawal B. Diminazene aceturate modified nanocomposite for improved efficacy in acute trypanosome infection. J Acute Dis. 2018;7:36. [DOI: 10.4103/2221-6189.228876]
  122. Singh SP, Kumari M, Kumari SI, Rahman MF, Mahboob M, Grover P. Toxicity assessment of manganese oxide micro and nanoparticles in Wistar rats after 28 days of repeated oral exposure. J Appl Toxicol. 2013a;33(10):1165–79. [DOI: 10.1002/jat.2887]
  123. Singh SP, Kumari M, Kumari SI, Rahman MF, Kamal SK, Mahboob M, Grover P. Genotoxicity of nano-and micron-sized manganese oxide in rats after acute oral treatment. Mutat Res Genet Toxicol Environ Mutagen. 2013b;754(1–2):39–50. [DOI: 10.1016/j.mrgentox.2013.04.003]
  124. Singh R, Patil S, Singh N, Gupta S. Dual functionality nanobioconjugates targeting intracellular bacteria in cancer cells with enhanced antimicrobial activity. Sci Rep. 2017a;7(1):1–10.
  125. Singh SP, Bhargava CS, Dubey V, Mishra A, Singh Y. Silver nanoparticles: biomedical applications, toxicity, and safety issues. Int J Res Pharm Pharm Sci. 2017b;4(2):01–10.
  126. Skuridin SG, Dubinskaya VA, Rudoy VM, Dement’eva OV, Zakhidov ST, Marshak TL, et al. Effect of gold nanoparticles on DNA package in model systems. In: Doklady. Biochemistry and biophysics, vol. 432, no. 1. Dordrecht: Springer Nature BV. p. 141; 2010.
  127. Smith MA, Michael R, Aravindan RG, Dash S, Shah SI, Galileo DS, Martin-DeLeon PA. Anatase titanium dioxide nanoparticles in mice: evidence for induced structural and functional sperm defects after short-, but not long-, term exposure. Asian J Androl. 2015;17(2):261.
  128. Solaiman AA, Ramadan H, Eid AA. Histologic study of the possible protective effect of resveratrol versus resveratrol-loaded niosomes against titanium dioxide nanoparticles-induced toxicity on adult rat seminiferous tubules. Egypt. J. Histol. 2020;43(4):1143–61.
  129. Song MK, Zhang Y, Cairns EJ. A long-life, high-rate lithium/sulfur cell: a multifaceted approach to enhancing cell performance. Nano Lett. 2013;13(12):5891–9. [DOI: 10.1021/nl402793z]
  130. Srám RJ, Binková B, Rössner P, Rubes J, Topinka J, Dejmek J. Adverse reproductive outcomes from exposure to environmental mutagens. Mutat Res. 1999;428(1–2):203–15. [DOI: 10.1016/S1383-5742(99)00048-4]
  131. Stelzer R, Hutz RJ. Gold nanoparticles enter rat ovarian granulosa cells and subcellular organelles, and alter in-vitro estrogen accumulation. J Reprod Dev. 2009:0909170201.
  132. Sun RWY, Chen R, Chung NPY, Ho CM, Lin CLS, Che CM. Silver nanoparticles fabricated in Hepes buffer exhibit cytoprotective activities toward HIV-1 infected cells. Chem Commun. 2005;40:5059–61. [DOI: 10.1039/b510984a]
  133. Tassinari R, Cubadda F, Moracci G, Aureli F, D’Amato M, Valeri M, De Berardis B, Raggi A, Mantovani A, Passeri D, Rossi M. Oral, short-term exposure to titanium dioxide nanoparticles in Sprague-Dawley rat: focus on reproductive and endocrine systems and spleen. Nanotoxicology. 2014;8(6):654–62.
  134. Tavakoli F, Jahanban-Esfahlan R, Seidi K, Jabbari M, Behzadi R, Pilehvar-Soltanahmadi Y, Zarghami N. Effects of nano-encapsulated curcumin-chrysin on telomerase, MMPs and TIMPs gene expression in mouse B16F10 melanoma tumour model. Artif Cells Nanomed Biotechnol. 2018;46(sup2):75–86. [DOI: 10.1080/21691401.2018.1452021]
  135. Taylor U, Petersen S, Barchanski A, Mittag A, Barcikowski S, Rath D. Influence of gold nanoparticles on vitality parameters of bovine spermatozoa. In: Reproduction in domestic animals, vol. 45. Malden: Wiley-Blackwell Publishing, Inc; 2010. p. 60.
  136. Taylor UAWE, Barchanski A, Garrels W, Klein S, Kues W, Barcikowski S, Rath D. Toxicity of gold nanoparticles on somatic and reproductive cells. In: Nano-biotechnology for biomedical and diagnostic Research. Dordrecht: Springer; 2012. p. 125–33.
  137. Tian J, Hu J, Liu G, Yin H, Chen M, Miao P, et al. Altered Gene expression of ABC transporters, nuclear receptors and oxidative stress signaling in zebrafish embryos exposed to CdTe quantum dots. Environ Pollut. 2019;244:588–99. [DOI: 10.1016/j.envpol.2018.10.092]
  138. Tiedemann D, Taylor U, Rehbock C, Jakobi J, Klein S, Kues WA, et al. Reprotoxicity of gold, silver, and gold–silver alloy nanoparticles on mammalian gametes. Analyst. 2014;139(5):931–42. [DOI: 10.1039/C3AN01463K]
  139. Tran N, Webster TJ. Nanotechnology for bone materials. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 2009;1(3):336–51.
  140. Walczak-Jedrzejowska R, Wolski JK, Slowikowska-Hilczer J. The role of oxidative stress and antioxidants in male fertility. Cent Eur J Urol. 2013;66:60. [DOI: 10.5173/ceju.2013.01.art19]
  141. Wang E, Huang Y, Du Q, Sun Y. Silver nanoparticles (AgNPs) induced changes of reproductive parameters and gene expression was involved in apoptosis in the murine male testis. Fertil Steril. 2016a;106(3):e283–4. [DOI: 10.1016/j.fertnstert.2016.07.815]
  142. Wang Z, Xie D, Liu H, Bao Z, Wang Y. Toxicity assessment of precise engineered gold nanoparticles with different shapes in zebrafish embryos. RSC Adv. 2016b;6(39):33009–13. [DOI: 10.1039/C6RA00632A]
  143. Wei W, Cui X, Chen W, Ivey DG. Manganese oxide-based materials as electrochemical supercapacitor electrodes. Chem Soc Rev. 2011;40(3):1697–721. [DOI: 10.1039/C0CS00127A]
  144. Wiesenthal A, Hunter L, Wang S, Wickliffe J, Wilkerson M. Nanoparticles: small and mighty. Int J Dermatol. 2011;50(3):247–54.
  145. Wiwanitkit V, Sereemaspun A, Rojanathanes R. Effect of gold nanoparticles on spermatozoa: the first world report. Fertil Steril. 2009;91(1):e7–8. [DOI: 10.1016/j.fertnstert.2007.08.021]
  146. Xu L, Wang YY, Huang J, Chen CY, Wang ZX, Xie H. Silver nanoparticles: synthesis, medical applications and biosafety. Theranostics. 2020;10(20):8996. [DOI: 10.7150/thno.45413]
  147. Yahyaei B, Nouri M, Bakherad S, Hassani M, Pourali P. Effects of biologically produced gold nanoparticles: toxicity assessment in different rat organs after intraperitoneal injection. AMB Express. 2019;9(1):1–12. [DOI: 10.1186/s13568-019-0762-0]
  148. Yan SQ, Xing R, Zhou YF, Li KL, Su YY, Qiu JF, et al. Reproductive toxicity and gender differences induced by cadmium telluride quantum dots in an invertebrate model organism. Sci Rep. 2016;6(1):1–16. [DOI: 10.1038/srep34182]
  149. Yang H, Sun C, Fan Z, Tian X, Yan L, Du L, et al. Effects of gestational age and surface modification on materno-fetal transfer of nanoparticles in murine pregnancy. Sci Rep. 2012;2(1):1–8. [DOI: 10.1038/srep00847]
  150. Yokota S, Moriya N, Iwata M, Umezawa M, Oshio S, Takeda K. Exposure to diesel exhaust during fetal period affects behavior and neurotransmitters in male offspring mice. J Toxicol Sci. 2013;38(1):13–23. [DOI: 10.2131/jts.38.13]
  151. Younus AI, Yousef MI, Abdel-Nabi KM, Younus MI, Abdulrahman JM. Reproductive toxicity of iron oxide nanoparticles, silver nanoparticles and their mixture in male rats: effects on testicular gene expression. World J Adv Res Rev. 2020;7(2):075–81. [DOI: 10.30574/wjarr.2020.7.2.0278]
  152. Yousefalizadegan N, Mousavi Z, Rastegar T, Razavi Y, Najafizadeh P. Reproductive toxicity of manganese dioxide in forms of micro-and nanoparticles in male rats. Int J Reprod BioMed. 2019;17(5):361.
  153. Yuan YG, Peng QL, Gurunathan S. Silver nanoparticles enhance the apoptotic potential of gemcitabine in human ovarian cancer cells: combination therapy for effective cancer treatment. Int J Nanomedicine. 2017;12:6487. [DOI: 10.2147/IJN.S135482]
  154. Zaitseva NV, Zemlyanova MA. Toxicologic characteristics of nanodisperse manganese oxide: physical-chemical properties, biological accumulation, and morphological-functional properties at various exposure types. In: Heavy metal toxicity in public health. IntechOpen; 2019.
  155. Ze Y, Sheng L, Zhao X, Hong J, Ze X, Yu X, Pan X, Lin A, Zhao Y, Zhang C, Zhou Q. TiO2 nanoparticles induced hippocampal neuroinflammation in mice. PloS one. 2014;9(3):e92230.
  156. Zhang XF, Choi YJ, Han JW, Kim E, Park JH, Gurunathan S, Kim JH. Differential nanoreprotoxicity of silver nanoparticles in male somatic cells and spermatogonial stem cells. Int J Nanomedicine. 2015;10:1335.
  157. Zhang L, Xie X, Zhou Y, Yu D, Deng Y, Ouyang J, Yang B, Luo D, Zhang D, Kuang H. Gestational exposure to titanium dioxide nanoparticles impairs the placentation through dysregulation of vascularization, proliferation and apoptosis in mice. Int J Nanomedicine. 2018;13:777.
  158. Zhang X, Yue Z, Zhang H, Liu L, Zhou X. Repeated administrations of Mn3O4 nanoparticles cause testis damage and fertility decrease through PPAR-signaling pathway. Nanotoxicology. 2020;14(3):326–40. [DOI: 10.1080/17435390.2019.1695976]
  159. Zielinska E, Zauszkiewicz-Pawlak A, Wojcik M, Inkielewicz-Stepniak I. Silver nanoparticles of different sizes induce a mixed type of programmed cell death in human pancreatic ductal adenocarcinoma. Oncotarget. 2018;9(4):4675. [DOI: 10.18632/oncotarget.22563]

MeSH Term

Humans
Male
Semen
Sperm Motility
Nanotechnology
Journal Article

Word Cloud

Created with Highcharts 10.0.0nanoparticlesreproductiveeffectsstudiestoxicitymetallicalsospermpossibledeleteriousduedemonstratedalteredchangesnanomaterialsNanotechnologicaltoolsgreatlyexploitedfieldsHoweveradvancementnanotechnologyraisedconcernadversehumanenvironmentignoredneedexploredsafetypurposeSeveralrecenthealthhazardorganismMoreovershowednanomaterialleadVariousdecreasedmotilityincreasedabnormalspermatozoacountmorphologyMorphologicalultrastructuralreportedaccumulationorgansNonethelesssuggestcrossingbloodtestesbarriergenerationoxidativestressplaysmajorrolepresentstudyincorporatedupdatedinformationgatheringavailableliteraturevariousriskrelatedsystemPerspectiveReproductiveToxicityMetallicNanomaterialsFertilityGoldHistopathologicalIronoxideReactiveoxygenspeciesTeratogenicity

Similar Articles

Cited By