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International journal of molecular sciences
Nov 27, 2022;23 (23):

Metal Complexes with Schiff Bases: Data Collection and Recent Studies on Biological Activities.

Maria Stefania Sinicropi, Jessica Ceramella, Domenico Iacopetta, Alessia Catalano, Annaluisa Mariconda, Camillo Rosano, Carmela Saturnino, Hussein El-Kashef, Pasquale Longo
Author Information
  1. Maria Stefania Sinicropi: Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, Italy. ORCID
  2. Jessica Ceramella: Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, Italy. ORCID
  3. Domenico Iacopetta: Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, Italy. ORCID
  4. Alessia Catalano: Department of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", 70126 Bari, Italy. ORCID
  5. Annaluisa Mariconda: Department of Science, University of Basilicata, 85100 Potenza, Italy. ORCID
  6. Camillo Rosano: Proteomics and Mass Spectrometry Unit, IRCCS Policlinico San Martino, Largo Rosanna Benzi, 10, 16132 Genoa, Italy. ORCID
  7. Carmela Saturnino: Department of Science, University of Basilicata, 85100 Potenza, Italy. ORCID
  8. Hussein El-Kashef: Department of Chemistry, Faculty of Science, Assiut University, Assiut 71516, Egypt.
  9. Pasquale Longo: Department of Chemistry and Biology, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy. ORCID
PMID: 36499170 DOI: 10.3390/ijms232314840

Abstract

Metal complexes play a crucial role in pharmaceutical sciences owing to their wide and significant activities. Schiff bases (SBs) are multifaceted pharmacophores capable of forming chelating complexes with various metals in different oxidation states. Complexes with SBs are extensively studied for their numerous advantages, including low cost and simple synthetic strategies. They have been reported to possess a variety of biological activities, including antimicrobial, anticancer, antioxidant, antimalarial, analgesic, antiviral, antipyretic, and antidiabetic ones. This review summarizes the most recent studies on the antimicrobial and antiproliferative activities of SBs-metal complexes. Moreover, recent studies regarding mononuclear and binuclear complexes with SBs are described, including antioxidant, antidiabetic, antimalarial, antileishmanial, anti-Alzheimer, and catecholase activities.

Keywords

Alzheimer disease Schiff bases antibacterial antileishmanial antimalarial antimicrobial antiproliferative diabetes imine metal complexes

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MeSH Term

Coordination Complexes
Schiff Bases
Metals
Anti-Infective Agents
Antioxidants
Data Collection

Chemicals

Coordination Complexes
Schiff Bases
Metals
Anti-Infective Agents
Antioxidants
Journal Article Review
Article has an altmetric score of 4

Word Cloud

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