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Nov 24, 2022;10 (12):

A Possibility of Vasospastic Angina after mRNA COVID-19 Vaccination.

Toru Awaya, Masao Moroi, Fuminori Nakamura, Satoru Toi, Momoko Wakiya, Yoshinari Enomoto, Taeko Kunimasa, Masato Nakamura
Author Information
  1. Toru Awaya: Department of Cardiovascular Medicine, Toho University Ohashi Medical Center, 2-22-36 Ohashi Meguro-ku, Tokyo 153-8515, Japan.
  2. Masao Moroi: Department of Cardiovascular Medicine, Toho University Ohashi Medical Center, 2-22-36 Ohashi Meguro-ku, Tokyo 153-8515, Japan.
  3. Fuminori Nakamura: Department of Cardiovascular Medicine, Toho University Ohashi Medical Center, 2-22-36 Ohashi Meguro-ku, Tokyo 153-8515, Japan.
  4. Satoru Toi: Department of Cardiovascular Medicine, Toho University Ohashi Medical Center, 2-22-36 Ohashi Meguro-ku, Tokyo 153-8515, Japan.
  5. Momoko Wakiya: Department of Cardiovascular Medicine, Toho University Ohashi Medical Center, 2-22-36 Ohashi Meguro-ku, Tokyo 153-8515, Japan.
  6. Yoshinari Enomoto: Department of Cardiovascular Medicine, Toho University Ohashi Medical Center, 2-22-36 Ohashi Meguro-ku, Tokyo 153-8515, Japan.
  7. Taeko Kunimasa: Department of Cardiovascular Medicine, Toho University Ohashi Medical Center, 2-22-36 Ohashi Meguro-ku, Tokyo 153-8515, Japan.
  8. Masato Nakamura: Department of Cardiovascular Medicine, Toho University Ohashi Medical Center, 2-22-36 Ohashi Meguro-ku, Tokyo 153-8515, Japan.
PMID: 36560408 DOI: 10.3390/vaccines10121998

Abstract

We report a case of vasospastic angina (VSA) following COVID-19 mRNA vaccination. Despite the widespread occurrence of myocarditis, there have been few reports of post-vaccinal VSA. A 41-year-old male patient was referred for chest pain at rest following mRNA vaccination; he had never experienced chest pain prior to vaccination. He was diagnosed by an acetylcholine (Ach) provocation test that showed multivessel vasospasm. After the initiation of treatment with a calcium channel blocker and nitrate, no further exacerbation of chest pain was observed. To our knowledge, this constitutes the first reported case of VSA proven by Ach provocation test after COVID-19 vaccination. The vaccination may increase coronary artery spasticity. VSA should be ruled out in post-vaccine new onset resting chest pain.

Keywords

COVID-19 vaccination adverse reaction alcohol angiotensin-converting enzyme 2 cardiovascular diseases inflammatory cytokine lipid nanoparticles vasospastic angina

References

  1. Eur Heart J. 2017 Sep 1;38(33):2565-2568 [PMID: 26245334]
  2. Circ J. 2016 Dec 22;81(1):96-102 [PMID: 27904031]
  3. Am Heart J. 1981 Nov;102(5):819-22 [PMID: 6795908]
  4. Eur Heart J. 2004 Jun;25(11):970-7 [PMID: 15172469]
  5. Intern Med. 2022 Sep 1;61(17):2693-2695 [PMID: 35768219]
  6. Eur Cardiol. 2021 Sep 03;16:e30 [PMID: 34603510]
  7. Monaldi Arch Chest Dis. 2006 Mar;66(1):13-9 [PMID: 17125042]
  8. J Cardiovasc Med (Hagerstown). 2018 Feb;19 Suppl 1:e84-e87 [PMID: 29538150]
  9. Vaccines (Basel). 2022 May 28;10(6): [PMID: 35746474]
  10. Eur J Intern Med. 2020 Jun;76:14-20 [PMID: 32336612]
  11. Vaccines (Basel). 2021 Mar 05;9(3): [PMID: 33807579]
  12. Circ J. 2013;77(2):301-8 [PMID: 23328447]
  13. Atherosclerosis. 2007 Sep;194(1):125-33 [PMID: 17109863]
  14. iScience. 2021 Dec 17;24(12):103479 [PMID: 34841223]
  15. Adv Exp Med Biol. 2021;1321:109-113 [PMID: 33656717]
  16. Recenti Prog Med. 2005 Sep;96(9):411-5 [PMID: 16229320]
  17. Immunity. 2021 Dec 14;54(12):2877-2892.e7 [PMID: 34852217]
  18. Nanomedicine. 2014 May;10(4):775-82 [PMID: 24361386]
  19. Cardiol J. 2017;24(4):403-408 [PMID: 28353311]
  20. J Korean Med Sci. 2021 May 31;36(21):e153 [PMID: 34060261]
  21. Lancet Infect Dis. 2022 Jun;22(6):802-812 [PMID: 35271805]
  22. QJM. 2021 Sep 29;: [PMID: 34586408]
  23. Front Immunol. 2022 Aug 15;13:967226 [PMID: 36045681]
  24. Rev Esp Cardiol (Engl Ed). 2022 May;75(5):444-446 [PMID: 34824040]
Case Reports Journal Article
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