Investigation of d-Amino Acid-Based Surfactants and Nanocomposites with Gold and Silica Nanoparticles as against Multidrug-Resistant Bacteria Agents.
Jae Ho Shim, Sungduk Gwak, Byung Kook Ahn, Hogyu Han, Yeonsun Hong, Ok Sarah Shin
Author Information
Jae Ho Shim: Department of Anatomy, Korea University College of Medicine, Seoul 02842, Korea. ORCID
Sungduk Gwak: Department of Chemistry, Korea University, Seoul 02841, Korea. ORCID
Byung Kook Ahn: Department of Anatomy, Korea University College of Medicine, Seoul 02842, Korea.
Hogyu Han: Department of Chemistry, Korea University, Seoul 02841, Korea.
Yeonsun Hong: Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York 14642, United States.
Ok Sarah Shin: BK21 Graduate Program, Department of Biomedical Sciences, College of Medicine, Korea University Guro Hospital, Seoul 08308, Korea.
d-amino acid-based surfactants (d-AASs) were synthesized and their antimicrobial activity was evaluated. -α-lauroyl-d-arginine ethyl ester hydrochloride (d-LAE), d-proline dodecyl ester (d-PD), and d-alanine dodecyl ester (d-AD) were found to have antibacterial activity against both Gram-positive and -negative bacteria, but less efficacy against Gram-negative bacteria. For these reasons, combining antimicrobial agents with nanoparticles is a promising technique for improving their antibacterial properties to eliminate drug-resistant pathogens. d-LAE coated on gold (AuNP) and silica (SiNP) nanoparticles has more efficient antibacterial activity than that of d-LAE alone. However, unlike d-LAE, d-PD has enhanced antibacterial activity upon being coated on AuNP. The antibacterial d-AASs and their nanocomposites with nanoparticles were synthesized in an environmentally friendly manner and are expected to be valuable new antimicrobial agents against multidrug-resistant (MDR) pathogens.
