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02 06, 2023;68 (4):

estimation of anisotropic mechanical properties of the gastrocnemius during functional loading with MR elastography.

Daniel R Smith, Diego A Caban-Rivera, L Tyler Williams, Elijah E W Van Houten, Phil V Bayly, Keith D Paulsen, Matthew D J McGarry, Curtis L Johnson
Author Information
  1. Daniel R Smith: Department of Biomedical Engineering, University of Delaware, 19711, Newark DE, United States of America. ORCID
  2. Diego A Caban-Rivera: Department of Biomedical Engineering, University of Delaware, 19711, Newark DE, United States of America.
  3. L Tyler Williams: Department of Biomedical Engineering, University of Delaware, 19711, Newark DE, United States of America.
  4. Elijah E W Van Houten: Université de Sherbrooke, Sherbrooke, QC, J1K 2R1, Canada.
  5. Phil V Bayly: Department of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis MO, United States of America.
  6. Keith D Paulsen: Thayer School of Engineering, Dartmouth College, 03755, Hanover NH, United States of America.
  7. Matthew D J McGarry: Thayer School of Engineering, Dartmouth College, 03755, Hanover NH, United States of America.
  8. Curtis L Johnson: Department of Biomedical Engineering, University of Delaware, 19711, Newark DE, United States of America.
PMID: 36652716 DOI: 10.1088/1361-6560/acb482

Abstract

.imaging assessments of skeletal muscle structure and function allow for longitudinal quantification of tissue health. Magnetic resonance elastography (MRE) non-invasively quantifies tissue mechanical properties, allowing for evaluation of skeletal muscle biomechanics in response to loading, creating a better understanding of muscle functional health.. In this study, we analyze the anisotropic mechanical response of calf muscles using MRE with a transversely isotropic, nonlinear inversion algorithm (TI-NLI) to investigate the role of muscle fiber stiffening under load. We estimate anisotropic material parameters including fiber shear stiffness (μ1), substrate shear stiffness (μ2), shear anisotropy (ϕ), and tensile anisotropy (ζ) of the gastrocnemius muscle in response to both passive and active tension.. In passive tension, we found a significant increase inμ1,ϕ,andζwith increasing muscle length. While in active tension, we observed increasingμ2and decreasingϕandζduring active dorsiflexion and plantarflexion-indicating less anisotropy-with greater effects when the muscles act as agonist.. The study demonstrates the ability of this anisotropic MRE method to capture the multifaceted mechanical response of skeletal muscle to tissue loading from muscle lengthening and contraction.

Keywords

gastrocnemius magnetic resonance elastography skeletal muscle stiffness tension

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Grants

  1. R01 EB027577/NIBIB NIH HHS

MeSH Term

Elasticity Imaging Techniques
Anisotropy
Muscle, Skeletal
Magnetic Resonance Imaging
Biomechanical Phenomena
Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, N.I.H., Extramural

Word Cloud

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