Adding High-Intensity Interval Training to Classical Resistance Training Does Not Impede the Recovery from Inactivity-Induced Leg Muscle Weakness.
Tomas Venckunas, Marius Brazaitis, Audrius Snieckus, Mantas Mickevicius, Nerijus Eimantas, Andrejus Subocius, Dalia Mickeviciene, Håkan Westerblad, Sigitas Kamandulis
Author Information
Tomas Venckunas: Institute of Sports Science and Innovations, Lithuanian Sports University, 44221 Kaunas, Lithuania. ORCID
Marius Brazaitis: Institute of Sports Science and Innovations, Lithuanian Sports University, 44221 Kaunas, Lithuania. ORCID
Audrius Snieckus: Institute of Sports Science and Innovations, Lithuanian Sports University, 44221 Kaunas, Lithuania.
Mantas Mickevicius: Institute of Sports Science and Innovations, Lithuanian Sports University, 44221 Kaunas, Lithuania.
Nerijus Eimantas: Institute of Sports Science and Innovations, Lithuanian Sports University, 44221 Kaunas, Lithuania.
Andrejus Subocius: Institute of Sports Science and Innovations, Lithuanian Sports University, 44221 Kaunas, Lithuania.
Dalia Mickeviciene: Institute of Sports Science and Innovations, Lithuanian Sports University, 44221 Kaunas, Lithuania.
Håkan Westerblad: Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden. ORCID
Sigitas Kamandulis: Institute of Sports Science and Innovations, Lithuanian Sports University, 44221 Kaunas, Lithuania.
Inactivity is known to induce muscle weakness, and chronically increased levels of reactive oxygen species (ROS) are proposed to have a central causative role in this process. Intriguingly, high-intensity interval training (HIIT), which involves bursts of high ROS production, can have positive effects in pathological conditions with chronically increased ROS. Here, young male volunteers were exposed to 3 weeks of unloading of the dominant leg followed by 3 weeks of resistance training without (Ctrl group) or with the addition of all-out cycling HIIT. Changes in muscle thickness were assessed by ultrasonography, and contractile function was studied by measuring the torque during maximal voluntary contractions (MVC). The results show an ~6% decrease in vastus lateralis thickness after the unloading period, which was fully restored after the subsequent training period in both the Ctrl and HIIT groups. MVC torque was decreased by ~11% after the unloading period and recovered fully during the subsequent training period in both groups. All-out cycling performance was improved by the 3 weeks of HIIT. In conclusion, the decline in muscle size and function after 3 weeks of unloading was restored by 3 weeks of resistance training regardless of whether it was combined with HIIT.
