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International journal of molecular sciences
Jan 12, 2023;24 (2):

Rejuvenating the Activity of Usual Antibiotics on Resistant Gram-Negative Bacteria: Recent Issues and Perspectives.

Jinane Tabcheh, Julia Vergalli, Anne Davin-R��gli, Noha Ghanem, Jean-Marie Pages, Charbel Al-Bayssari, Jean Michel Brunel
Author Information
  1. Jinane Tabcheh: Aix Marseille University, INSERM, SSA, MCT, 13385 Marseille, France.
  2. Julia Vergalli: Aix Marseille University, INSERM, SSA, MCT, 13385 Marseille, France. ORCID
  3. Anne Davin-R��gli: Aix Marseille University, INSERM, SSA, MCT, 13385 Marseille, France. ORCID
  4. Noha Ghanem: Faculty of Science 3, Lebanese University, Michel Slayman Tripoli Campus, Tripoli 1352, Lebanon.
  5. Jean-Marie Pages: Aix Marseille University, INSERM, SSA, MCT, 13385 Marseille, France. ORCID
  6. Charbel Al-Bayssari: Department of Medical Laboratory Sciences, Faculty of Health Sciences, University of Balamand, Beirut P.O. Box 55251, Lebanon. ORCID
  7. Jean Michel Brunel: Aix Marseille University, INSERM, SSA, MCT, 13385 Marseille, France. ORCID
PMID: 36675027 DOI: 10.3390/ijms24021515

Abstract

Antibiotic resistance continues to evolve and spread beyond all boundaries, resulting in an increase in morbidity and mortality for non-curable infectious diseases. Due to the failure of conventional antimicrobial therapy and the lack of introduction of a novel class of antibiotics, novel strategies have recently emerged to combat these multidrug-resistant infectious microorganisms. In this review, we highlight the development of effective antibiotic combinations and of antibiotics with non-antibiotic activity-enhancing compounds to address the widespread emergence of antibiotic-resistant strains.

Keywords

antibiotic activity enhancement bacteria gram-negative multi drug resistance new strategies

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MeSH Term

Anti-Bacterial Agents
Drug Resistance, Multiple, Bacterial
Gram-Negative Bacteria
Anti-Infective Agents

Chemicals

Anti-Bacterial Agents
Anti-Infective Agents
Journal Article Review

Word Cloud

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