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Frontiers in immunology
2022;13 1025945.

Apoptosis in megakaryocytes: Safeguard and threat for thrombopoiesis.

Shuo Yang, Long Wang, Yuesong Wu, Anguo Wu, Feihong Huang, Xiaoqin Tang, Fahsai Kantawong, Songyot Anuchapreeda, Dalian Qin, Qibing Mei, Jianping Chen, Xinwu Huang, Chunxiang Zhang, Jianming Wu
Author Information
  1. Shuo Yang: School of Pharmacy, Southwest Medical University, Luzhou, China.
  2. Long Wang: School of Pharmacy, Southwest Medical University, Luzhou, China.
  3. Yuesong Wu: School of Pharmacy, Southwest Medical University, Luzhou, China.
  4. Anguo Wu: School of Pharmacy, Southwest Medical University, Luzhou, China.
  5. Feihong Huang: School of Pharmacy, Southwest Medical University, Luzhou, China.
  6. Xiaoqin Tang: School of Pharmacy, Southwest Medical University, Luzhou, China.
  7. Fahsai Kantawong: Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
  8. Songyot Anuchapreeda: Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
  9. Dalian Qin: School of Pharmacy, Southwest Medical University, Luzhou, China.
  10. Qibing Mei: School of Pharmacy, Southwest Medical University, Luzhou, China.
  11. Jianping Chen: School of Chinese Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
  12. Xinwu Huang: School of Pharmacy, Southwest Medical University, Luzhou, China.
  13. Chunxiang Zhang: Institute of Cardiovascular Research, the Key Laboratory of Medical Electrophysiology, Ministry of Education of China, Medical Key Laboratory for Drug Discovery and Druggability Evaluation of Sichuan Province, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, Luzhou, China.
  14. Jianming Wu: School of Pharmacy, Southwest Medical University, Luzhou, China.
PMID: 36685543 DOI: 10.3389/fimmu.2022.1025945

Abstract

Platelets, generated from precursor megakaryocytes (MKs), are central mediators of hemostasis and thrombosis. The process of thrombopoiesis is extremely complex, regulated by multiple factors, and related to many cellular events including apoptosis. However, the role of apoptosis in thrombopoiesis has been controversial for many years. Some researchers believe that apoptosis is an ally of thrombopoiesis and platelets production is apoptosis-dependent, while others have suggested that apoptosis is dispensable for thrombopoiesis, and is even inhibited during this process. In this review, we will focus on this conflict, discuss the relationship between megakaryocytopoiesis, thrombopoiesis and apoptosis. In addition, we also consider why such a vast number of studies draw opposite conclusions of the role of apoptosis in thrombopoiesis, and try to figure out the truth behind the mystery. This review provides more comprehensive insights into the relationship between megakaryocytopoiesis, thrombopoiesis, and apoptosis and finds some clues for the possible pathological mechanisms of platelet disorders caused by abnormal apoptosis.

Keywords

apoptosis apoptosis-related molecules autophagy megakaryocytopoiesis thrombopoiesis

References

  1. J Cell Biochem. 2009 Jun 1;107(3):377-82 [PMID: 19350569]
  2. Blood. 2003 Dec 1;102(12):4229-35 [PMID: 12907434]
  3. Autophagy. 2013 Jan;9(1):115-7 [PMID: 23079699]
  4. Blood. 2017 Jul 13;130(2):192-204 [PMID: 28455282]
  5. J Thromb Haemost. 2013 Apr;11(4):593-604 [PMID: 23311859]
  6. Cell Stem Cell. 2015 Oct 1;17(4):422-34 [PMID: 26299573]
  7. Nature. 2005 Jun 2;435(7042):677-81 [PMID: 15902208]
  8. Int J Mol Sci. 2020 Dec 09;21(24): [PMID: 33317046]
  9. Cell Prolif. 2018 Feb;51(1): [PMID: 29193421]
  10. Blood. 2016 Feb 18;127(7):921-6 [PMID: 26647394]
  11. Leukemia. 2002 Jan;16(1):67-73 [PMID: 11840265]
  12. Front Immunol. 2021 Feb 26;12:607836 [PMID: 33717090]
  13. J Family Med Prim Care. 2017 Oct-Dec;6(4):859-861 [PMID: 29564278]
  14. Mol Cell Biol. 2009 Aug;29(15):4103-15 [PMID: 19470763]
  15. Cell Death Dis. 2016 Nov 24;7(11):e2485 [PMID: 27882946]
  16. Autophagy. 2010 Oct;6(7):961-3 [PMID: 20724821]
  17. Blood. 2015 Oct 15;126(16):1877-84 [PMID: 26330242]
  18. Int J Mol Sci. 2015 Feb 13;16(2):4083-94 [PMID: 25689426]
  19. Mol Med. 2022 May 4;28(1):51 [PMID: 35508969]
  20. Blood. 2010 Nov 18;116(20):4307-16 [PMID: 20671119]
  21. Cell Death Dis. 2013 Nov 21;4:e931 [PMID: 24263105]
  22. J Thromb Haemost. 2020 Jul;18(7):1535-1547 [PMID: 32350996]
  23. Int J Mol Sci. 2018 Dec 12;19(12): [PMID: 30545052]
  24. Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14458-63 [PMID: 11734646]
  25. Trends Cell Biol. 2018 Dec;28(12):976-986 [PMID: 29935893]
  26. iScience. 2020 May 22;23(5):101070 [PMID: 32361594]
  27. Cell Death Discov. 2020 Sep 18;6(1):90 [PMID: 33024575]
  28. Biomed Res Int. 2017;2017:9017902 [PMID: 28210630]
  29. Inorg Chem. 2013 Nov 4;52(21):12234-49 [PMID: 23738524]
  30. Methods Mol Biol. 2014;1165:19-29 [PMID: 24839016]
  31. Cell Death Differ. 2016 Jun;23(6):990-6 [PMID: 26943319]
  32. Nat Chem Biol. 2011 Jul 18;7(8):504-11 [PMID: 21769097]
  33. Front Bioeng Biotechnol. 2020 Sep 25;8:573282 [PMID: 33330414]
  34. J Clin Invest. 2007 Sep;117(9):2672-83 [PMID: 17717601]
  35. J Thromb Haemost. 2015 Jun;13 Suppl 1:S55-62 [PMID: 26149051]
  36. Cytotherapy. 2011 Jan;13(1):114-28 [PMID: 20230224]
  37. J Biol Chem. 2000 Jul 21;275(29):22479-86 [PMID: 10801894]
  38. Int J Mol Sci. 2019 Dec 05;20(24): [PMID: 31817549]
  39. Cell Physiol Biochem. 2017;42(6):2364-2376 [PMID: 28848149]
  40. Science. 1999 Nov 26;286(5445):1735-8 [PMID: 10576740]
  41. Mitochondrion. 2020 Jan;50:115-120 [PMID: 31669618]
  42. Blood. 2008 Feb 1;111(3):981-6 [PMID: 18223171]
  43. Fac Rev. 2021 Sep 01;10:68 [PMID: 34557872]
  44. Toxicol Pathol. 2007 Jun;35(4):495-516 [PMID: 17562483]
  45. PLoS One. 2013;8(3):e59512 [PMID: 23555687]
  46. Alcohol Clin Exp Res. 2016 Jun;40(6):1215-23 [PMID: 27130888]
  47. Arch Biochem Biophys. 2010 Mar 15;495(2):97-111 [PMID: 20018168]
  48. Blood. 2000 Jun 1;95(11):3451-9 [PMID: 10828028]
  49. Nat Cell Biol. 2011 Mar;13(3):184-90 [PMID: 21364565]
  50. Cancer Chemother Pharmacol. 2016 Jun;77(6):1103-24 [PMID: 26886018]
  51. Mol Cancer Res. 2010 Jan;8(1):46-56 [PMID: 20068062]
  52. J Cell Biol. 2013 Jun 10;201(6):785-96 [PMID: 23751492]
  53. Blood Coagul Fibrinolysis. 2020 Jul;31(5):310-316 [PMID: 32398462]
  54. Arthritis Rheumatol. 2015 Oct;67(10):2679-90 [PMID: 26097038]
  55. Dev Cell. 2004 Apr;6(4):463-77 [PMID: 15068787]
  56. Proc Natl Acad Sci U S A. 1978 May;75(5):2458-62 [PMID: 276884]
  57. Cell Death Dis. 2013 Jul 11;4:e722 [PMID: 23846224]
  58. Blood Sci. 2020 May 09;2(2):44-49 [PMID: 35402814]
  59. Cell Rep. 2018 Nov 13;25(7):1772-1785.e6 [PMID: 30428347]
  60. Theranostics. 2021 Jan 1;11(2):470-490 [PMID: 33391487]
  61. PLoS One. 2015 Apr 14;10(4):e0125057 [PMID: 25875470]
  62. Haematologica. 2013 Sep;98(9):1335-43 [PMID: 24006406]
  63. Exp Hematol. 2002 Dec;30(12):1373-80 [PMID: 12482498]
  64. Biosci Rep. 2020 Aug 28;40(8): [PMID: 32779719]
  65. J Cell Biol. 2003 Feb 17;160(4):577-87 [PMID: 12591916]
  66. Blood. 2002 Oct 1;100(7):2421-9 [PMID: 12239152]
  67. Annu Rev Cell Dev Biol. 2016 Oct 6;32:399-409 [PMID: 27482603]
  68. Transfus Med Rev. 2010 Jan;24(1):33-43 [PMID: 19962573]
  69. J Hematother Stem Cell Res. 2003 Apr;12(2):179-88 [PMID: 12804177]
  70. J Exp Med. 1997 Feb 3;185(3):517-30 [PMID: 9053452]
  71. Blood. 2016 Oct 20;128(16):2022-2032 [PMID: 27503502]
  72. Blood. 2017 Jun 29;129(26):3486-3494 [PMID: 28432223]
  73. Cell Death Differ. 2018 Mar;25(4):797-808 [PMID: 29339775]
  74. Antioxidants (Basel). 2021 May 28;10(6): [PMID: 34071633]
  75. Hepatology. 2002 Sep;36(3):592-601 [PMID: 12198651]
  76. Blood. 2019 Mar 28;133(13):1427-1435 [PMID: 30728145]
  77. Nature. 2016 Jan 21;529(7586):326-35 [PMID: 26791723]
  78. Immunol Rev. 2017 Nov;280(1):8-25 [PMID: 29027219]
  79. PLoS One. 2021 Jan 11;16(1):e0244848 [PMID: 33428668]
  80. Autophagy. 2008 Feb;4(2):151-75 [PMID: 18188003]
  81. Viruses. 2013 Jan 21;5(1):340-51 [PMID: 23337384]
  82. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14943-8 [PMID: 10611317]
  83. Cell Death Dis. 2020 May 4;11(5):308 [PMID: 32366831]
  84. Stem Cell Reports. 2017 Jul 11;9(1):5-11 [PMID: 28648895]
  85. Semin Hematol. 2010 Jul;47(3):227-34 [PMID: 20620433]
  86. EMBO J. 2010 Jan 20;29(2):457-68 [PMID: 20010697]
  87. Arterioscler Thromb Vasc Biol. 2017 Nov;37(11):2007-2013 [PMID: 28982668]
  88. Br J Pharmacol. 2005 Jun;145(3):271-3 [PMID: 15778735]
  89. PLoS One. 2012;7(9):e44608 [PMID: 22970264]
  90. Int J Mol Sci. 2018 Oct 09;19(10): [PMID: 30304824]
  91. Curr Opin Genet Dev. 2020 Oct;64:1-5 [PMID: 32570191]
  92. Blood. 2004 Jan 15;103(2):517-22 [PMID: 12969966]
  93. J Hematol Oncol. 2015 Oct 23;8:116 [PMID: 26497387]
  94. Nat Rev Mol Cell Biol. 2008 Jan;9(1):47-59 [PMID: 18097445]
  95. Biochim Biophys Acta. 2009 Sep;1793(9):1461-4 [PMID: 19168096]
  96. Cancers (Basel). 2022 Oct 12;14(20): [PMID: 36291779]
  97. FEBS J. 2019 Feb;286(3):430-440 [PMID: 30506628]
  98. Cytokine Growth Factor Rev. 2006 Aug;17(4):245-57 [PMID: 16750931]
  99. Cell Death Dis. 2020 Jan 6;11(1):8 [PMID: 31907357]
  100. J Clin Invest. 1997 Jul 15;100(2):350-6 [PMID: 9218511]
  101. Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):E8228-E8235 [PMID: 30104364]
  102. Biochim Biophys Acta. 2010 Apr;1805(2):123-40 [PMID: 19961901]
  103. Int J Hematol. 2012 Nov;96(5):600-10 [PMID: 22987294]
  104. Autophagy. 2009 Nov;5(8):1092-8 [PMID: 19786835]
  105. Exp Hematol. 2001 Jul;29(7):873-83 [PMID: 11438210]
  106. Blood. 1997 Sep 15;90(6):2234-43 [PMID: 9310474]
  107. Blood. 2002 Sep 1;100(5):1670-8 [PMID: 12176887]
  108. J Biol Chem. 2015 Mar 13;290(11):7304-13 [PMID: 25645916]
  109. Blood. 2002 Aug 15;100(4):1310-7 [PMID: 12149212]
  110. Nucleus. 2014;5(6):527-41 [PMID: 25482068]
  111. Oxid Med Cell Longev. 2019 Nov 4;2019:9030563 [PMID: 31781356]
  112. Biochim Biophys Acta. 2008 May;1780(5):757-63 [PMID: 18339327]
  113. Semin Hematol. 2017 Apr;54(2):75-80 [PMID: 28637620]
  114. Pharmaceuticals (Basel). 2019 Nov 17;12(4): [PMID: 31744203]
  115. Cell Death Dis. 2015 Apr 16;6:e1721 [PMID: 25880088]
  116. Blood. 2002 Aug 15;100(4):1111-2 [PMID: 12149186]
  117. Haematologica. 2020 Aug;105(8):2004-2019 [PMID: 32527953]
  118. Biochim Biophys Acta. 2016 Dec;1863(12):2977-2992 [PMID: 27646922]
  119. Nature. 2018 Feb 1;554(7690):106-111 [PMID: 29298288]
  120. Free Radic Biol Med. 2021 Mar;165:395-400 [PMID: 33548451]
  121. Platelets. 2018 Nov;29(7):729-732 [PMID: 29787328]
  122. Nat Commun. 2014 Mar 17;5:3455 [PMID: 24632563]
  123. Blood. 2010 Apr 22;115(16):3258-68 [PMID: 20185587]
  124. Cell. 2007 Mar 23;128(6):1173-86 [PMID: 17382885]
  125. Blood. 2004 Oct 15;104(8):2557-64 [PMID: 15238425]
  126. Platelets. 2016 Sep;27(6):497-504 [PMID: 27100842]
  127. Blood. 2018 Jul 12;132(2):210-222 [PMID: 29802222]
  128. J Exp Med. 2011 Sep 26;208(10):2017-31 [PMID: 21911424]
  129. J Cell Biol. 2004 May 10;165(3):347-56 [PMID: 15123740]
  130. Cell Death Differ. 2010 Dec;17(12):1842-54 [PMID: 20523355]
  131. Cancers (Basel). 2022 Jan 26;14(3): [PMID: 35158895]
  132. Annu Rev Immunol. 2001;19:623-55 [PMID: 11244049]
  133. Cell Death Dis. 2013 Nov 28;4:e937 [PMID: 24287698]
  134. Sci Rep. 2019 Feb 18;9(1):2208 [PMID: 30778108]
  135. Blood. 2005 May 1;105(9):3472-9 [PMID: 15542580]
  136. Br J Cancer. 1972 Aug;26(4):239-57 [PMID: 4561027]
  137. Mol Med Rep. 2021 Jun;23(6): [PMID: 33786632]
  138. Biomed Rep. 2016 Feb;4(2):153-160 [PMID: 26893830]
  139. Haematologica. 2019 Oct;104(10):2075-2083 [PMID: 30733267]
  140. Cancer Res. 2004 Dec 1;64(23):8502-6 [PMID: 15574753]
  141. Cancer Metab. 2021 Apr 21;9(1):17 [PMID: 33883040]
  142. Blood. 2016 Mar 10;127(10):1242-8 [PMID: 26787736]
  143. Cell. 2001 Feb 23;104(4):487-501 [PMID: 11239407]
  144. Blood Adv. 2021 Oct 26;5(20):4265-4277 [PMID: 34478523]
  145. Cell Biol Int. 2019 Jun;43(6):582-592 [PMID: 30958602]
  146. J Cell Biol. 2000 Aug 21;150(4):887-94 [PMID: 10953012]
  147. J Biol Chem. 2001 Sep 7;276(36):33869-74 [PMID: 11448953]
  148. Blood. 2005 Jul 15;106(2):494-504 [PMID: 15784726]
  149. Biochim Biophys Acta. 2013 Dec;1833(12):3460-3470 [PMID: 23850759]
  150. Platelets. 2019;30(7):809-816 [PMID: 30359163]
  151. Exp Hematol. 2015 Jun;43(6):488-94 [PMID: 25591498]
  152. PLoS Pathog. 2016 Apr 22;12(4):e1005591 [PMID: 27105352]
  153. Clin Cancer Res. 2005 May 1;11(9):3155-62 [PMID: 15867207]
  154. Nat Med. 2004 Mar;10(3):299-304 [PMID: 14966519]
  155. Exp Cell Res. 2010 Apr 1;316(6):887-99 [PMID: 20026107]
  156. Blood. 2018 Feb 8;131(6):605-610 [PMID: 29259001]
  157. Cell Death Differ. 2008 Jun;15(6):977-87 [PMID: 18369371]
  158. Mol Cell Biochem. 2006 Nov;292(1-2):155-67 [PMID: 16786195]
  159. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2432-7 [PMID: 12591950]
  160. Nature. 2018 Jan 11;553(7687):212-216 [PMID: 29323290]
  161. Int J Biochem Cell Biol. 2004 Dec;36(12):2405-19 [PMID: 15325581]
  162. Science. 2007 Sep 21;317(5845):1767-70 [PMID: 17885137]
  163. J Anim Sci Biotechnol. 2021 May 17;12(1):65 [PMID: 33993883]
  164. Nat Commun. 2020 Oct 2;11(1):4964 [PMID: 33009394]
  165. Cell Death Differ. 2018 Mar;25(3):486-541 [PMID: 29362479]
  166. Res Pract Thromb Haemost. 2021 May 03;5(4):e12506 [PMID: 33977209]
  167. Crit Rev Clin Lab Sci. 2016 Dec;53(6):409-30 [PMID: 27282765]
  168. Chin J Integr Med. 2016 Aug;22(8):611-8 [PMID: 25847779]
  169. Blood. 2007 Feb 15;109(4):1451-9 [PMID: 17047147]
  170. EMBO J. 2012 Jan 18;31(2):351-65 [PMID: 22068055]
  171. Front Cell Dev Biol. 2022 Jan 11;9:809516 [PMID: 35087837]
  172. Cell Mol Biol Lett. 2022 Mar 2;27(1):19 [PMID: 35236296]
  173. Molecules. 2020 Apr 04;25(7): [PMID: 32260423]
  174. Front Cell Neurosci. 2014 Jul 29;8:213 [PMID: 25120434]
  175. Apoptosis. 2016 Apr;21(4):432-42 [PMID: 26801321]
  176. Acta Pharm Sin B. 2018 Jan;8(1):14-22 [PMID: 29872619]
  177. Br J Haematol. 2014 Apr;165(2):259-68 [PMID: 24499199]
  178. Nanomaterials (Basel). 2021 Oct 21;11(11): [PMID: 34835553]
  179. Expert Rev Mol Med. 2016 Mar 08;18:e3 [PMID: 26953528]
  180. BMC Biol. 2018 Oct 18;16(1):116 [PMID: 30336771]
  181. Cell Mol Life Sci. 2013 Aug;70(16):3013-27 [PMID: 23475110]
  182. Int J Biochem Cell Biol. 2015 Sep;66:69-74 [PMID: 26210823]
  183. Exp Oncol. 2012 Oct;34(3):243-54 [PMID: 23070009]
  184. Free Radic Biol Med. 2010 Mar 15;48(6):749-62 [PMID: 20045723]

MeSH Term

Megakaryocytes
Thrombopoiesis
Blood Platelets
Hemostasis
Apoptosis
Fenbendazole

Chemicals

Fenbendazole
Journal Article Review Research Support, Non-U.S. Gov't
Article has an altmetric score of 1

Word Cloud

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