Synthesis and Evaluation of -Diaminophosphoryl Aminothioureas as Bifunctional Catalysts for Vinylogous Aldol Reactions of Isatins and 2(3)-Furanones.
Hrishikesh D V, Ritesh A Annadate, Sunil V Pansare
Author Information
Hrishikesh D V: Department of Chemistry, Memorial University, St. John's, Newfoundland and Labrador, Canada A1B 3X7.
Ritesh A Annadate: Department of Chemistry, Memorial University, St. John's, Newfoundland and Labrador, Canada A1B 3X7.
Sunil V Pansare: Department of Chemistry, Memorial University, St. John's, Newfoundland and Labrador, Canada A1B 3X7. ORCID
The organocatalytic asymmetric direct vinylogous aldol reaction of -methylisatins and γ-butenolides to provide 3-hydroxy-2-oxindole derivatives was investigated. A series of -diaminophosphoryl aminothiourea catalysts was synthesized, and their utility for the stereoselective formation of was examined.
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