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Frontiers in endocrinology
2022;13 1094394.

Endoplasmic reticulum stress associates with the development of intervertebral disc degeneration.

Jishang Huang, Qingluo Zhou, Qun Ren, Liliang Luo, Guanglin Ji, Tiansheng Zheng
Author Information
  1. Jishang Huang: Department of Orthopedics, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
  2. Qingluo Zhou: Department of Orthopedics, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
  3. Qun Ren: College of Pharmacy, Gannan Medical University, Ganzhou, China.
  4. Liliang Luo: Department of Orthopedics, Shangyou Hospital of traditional Chinese Medicine, Ganzhou, China.
  5. Guanglin Ji: Department of Orthopedics, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
  6. Tiansheng Zheng: Department of Orthopedics, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
PMID: 36714579 DOI: 10.3389/fendo.2022.1094394

Abstract

Endoplasmic reticulum (ER) is an important player in various intracellular signaling pathways that regulate cellular functions in many diseases. Intervertebral disc degeneration (IDD), an age-related degenerative disease, is one of the main clinical causes of low back pain. Although the pathological development of IDD is far from being fully elucidated, many studies have been shown that ER stress (ERS) is involved in IDD development and regulates various processes, such as inflammation, cellular senescence and apoptosis, excessive mechanical loading, metabolic disturbances, oxidative stress, calcium homeostasis imbalance, and extracellular matrix (ECM) dysregulation. This review summarizes the formation of ERS and the potential link between ERS and IDD development. ERS can be a promising new therapeutic target for the clinical management of IDD.

Keywords

ATF6 IRE1α PERK apoptosis endoplasmic reticulum stress intervertebral disc degeneration

References

  1. Nature. 2008 Jul 24;454(7203):455-62 [PMID: 18650916]
  2. Biores Open Access. 2018 Feb 01;7(1):2-9 [PMID: 29445584]
  3. Lancet. 2021 Dec 19;396(10267):2006-2017 [PMID: 33275908]
  4. Eur Spine J. 2019 Sep;28(9):2129-2144 [PMID: 31201565]
  5. Front Cell Dev Biol. 2022 Jan 31;9:803132 [PMID: 35174163]
  6. Transl Perioper Pain Med. 2019;6(3):81-90 [PMID: 31687422]
  7. Spine (Phila Pa 1976). 2006 Jun 15;31(14):1532-8 [PMID: 16778684]
  8. Osteoarthritis Cartilage. 2014 Jan;22(1):104-10 [PMID: 24239943]
  9. Int J Med Sci. 2021 May 27;18(13):2799-2813 [PMID: 34220308]
  10. Cell. 2009 Aug 7;138(3):562-75 [PMID: 19665977]
  11. Lancet. 2017 Feb 18;389(10070):736-747 [PMID: 27745712]
  12. Stem Cells Transl Med. 2016 Sep;5(9):1171-81 [PMID: 27388238]
  13. Dis Model Mech. 2019 Jun 20;12(6): [PMID: 31171565]
  14. J Cell Biol. 2019 Mar 4;218(3):929-948 [PMID: 30587510]
  15. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1395-E1404 [PMID: 28137856]
  16. Biosci Rep. 2018 Apr 13;38(2): [PMID: 29273676]
  17. J Biol Chem. 2019 Feb 8;294(6):2133-2141 [PMID: 30541925]
  18. Biosci Rep. 2020 Jun 26;40(7): [PMID: 32515472]
  19. Oxid Med Cell Longev. 2019 May 16;2019:8574386 [PMID: 31223428]
  20. Annu Rev Pathol. 2008;3:399-425 [PMID: 18039139]
  21. Spine (Phila Pa 1976). 2007 Nov 1;32(23):2596-603 [PMID: 17978660]
  22. BMC Musculoskelet Disord. 2002 Mar 21;3:9 [PMID: 11914152]
  23. Spine (Phila Pa 1976). 2005 Jan 1;30(1):44-53; discussion 54 [PMID: 15626980]
  24. Nat Rev Mol Cell Biol. 2012 Jan 18;13(2):89-102 [PMID: 22251901]
  25. J Orthop Res. 2014 Feb;32(2):253-61 [PMID: 24307209]
  26. Pediatr Res. 2002 Dec;52(6):832-6 [PMID: 12438657]
  27. DNA Cell Biol. 2018 Apr;37(4):347-358 [PMID: 29381432]
  28. Biochem Soc Trans. 2007 Aug;35(Pt 4):652-5 [PMID: 17635113]
  29. Acta Neuropathol. 2007 Nov;114(5):527-35 [PMID: 17661063]
  30. Science. 2007 Nov 9;318(5852):944-9 [PMID: 17991856]
  31. Cell Commun Signal. 2022 Mar 24;20(1):38 [PMID: 35331264]
  32. Life Sci. 2021 Jan 15;265:118740 [PMID: 33188833]
  33. J Cell Biol. 2004 Feb 2;164(3):341-6 [PMID: 14757749]
  34. IUBMB Life. 2016 Dec;68(12):943-954 [PMID: 27797166]
  35. Spine (Phila Pa 1976). 2009 May 15;34(11):1127-33 [PMID: 19407676]
  36. J Clin Neurosci. 2001 Jan;8(1):10-3 [PMID: 11320971]
  37. Ann N Y Acad Sci. 2007 Jan;1096:44-54 [PMID: 17405915]
  38. Science. 2012 Nov 9;338(6108):818-22 [PMID: 23042294]
  39. Adv Drug Deliv Rev. 2016 Feb 1;97:4-27 [PMID: 26562801]
  40. Trends Cell Biol. 2013 Nov;23(11):547-55 [PMID: 23880584]
  41. J Biol Chem. 2017 Oct 20;292(42):17216-17224 [PMID: 28860186]
  42. Trends Biochem Sci. 2014 May;39(5):245-54 [PMID: 24657016]
  43. J Cell Physiol. 2021 May;236(5):3780-3788 [PMID: 33151568]
  44. Arthritis Res Ther. 2015 Nov 05;17:316 [PMID: 26542776]
  45. Am J Physiol Cell Physiol. 2017 Feb 1;312(2):C93-C102 [PMID: 27856431]
  46. J Orthop Res. 2019 Mar;37(3):697-705 [PMID: 30561076]
  47. Biomed Res Int. 2021 May 17;2021:5510124 [PMID: 34055972]
  48. Cell Death Dis. 2016 Oct 27;7(10):e2441 [PMID: 27787519]
  49. Surg Neurol. 2006 Aug;66(2):152-4 [PMID: 16876608]
  50. Curr Opin Cell Biol. 2015 Apr;33:67-73 [PMID: 25543896]
  51. Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17775-80 [PMID: 19822759]
  52. Trends Biochem Sci. 2018 Aug;43(8):593-605 [PMID: 30056836]
  53. J Anat. 2020 Feb;236(2):243-251 [PMID: 31670389]
  54. Eur Cell Mater. 2015 Sep 04;30:89-102; discussion 103 [PMID: 26337541]
  55. Biomed Pharmacother. 2017 May;89:529-535 [PMID: 28254665]
  56. Spine (Phila Pa 1976). 2000 Jul 1;25(13):1625-36 [PMID: 10870137]
  57. Oxid Med Cell Longev. 2019 Sep 9;2019:7959573 [PMID: 31583043]
  58. Osteoarthritis Cartilage. 2016 Mar;24(3):398-408 [PMID: 26455958]
  59. Theranostics. 2019 May 31;9(14):4084-4100 [PMID: 31281533]
  60. Eur Cell Mater. 2021 Feb 23;41:194-203 [PMID: 33620083]
  61. Phytother Res. 2016 Nov;30(11):1745-1764 [PMID: 27528198]
  62. J Bone Joint Surg Am. 2006 Apr;88 Suppl 2:21-4 [PMID: 16595438]
  63. J Cell Physiol. 2016 Feb;231(2):288-94 [PMID: 26201832]
  64. Age (Dordr). 2010 Jun;32(2):161-77 [PMID: 19960285]
  65. Nature. 2016 Jan 21;529(7586):326-35 [PMID: 26791723]
  66. Mol Ther Nucleic Acids. 2020 Sep 26;22:601-614 [PMID: 33230460]
  67. Arthritis Rheum. 2012 Aug;64(8):2601-10 [PMID: 22392593]
  68. Chin J Nat Med. 2015 Dec;13(12):896-905 [PMID: 26721708]
  69. Science. 2001 May 25;292(5521):1552-5 [PMID: 11375494]
  70. Cell. 2009 Feb 20;136(4):731-45 [PMID: 19239892]
  71. Evid Based Complement Alternat Med. 2018 Mar 12;2018:6719460 [PMID: 29721028]
  72. Int J Mol Sci. 2017 Mar 20;18(3): [PMID: 28335520]
  73. Mol Cell. 2014 May 22;54(4):559-72 [PMID: 24746698]
  74. Cell Biol Int. 2022 Apr;46(4):568-578 [PMID: 35019194]
  75. J Cell Sci. 2014 Sep 1;127(Pt 17):3649-58 [PMID: 25107370]
  76. Cell Rep. 2013 Apr 25;3(4):1279-92 [PMID: 23583182]
  77. Antioxid Redox Signal. 2009 Oct;11(10):2409-27 [PMID: 19388824]
  78. Am J Chin Med. 2011;39(3):523-35 [PMID: 21598419]
  79. Int J Mol Sci. 2016 Mar 02;17(3):327 [PMID: 26950115]
  80. Spine (Phila Pa 1976). 2004 Mar 1;29(5):568-75 [PMID: 15129075]
  81. J Cell Physiol. 2019 Jul;234(7):11631-11645 [PMID: 30515797]
  82. Biomed Pharmacother. 2020 Nov;131:110660 [PMID: 32853910]
  83. Exp Ther Med. 2020 Oct;20(4):3244-3252 [PMID: 32855694]
  84. Eur Rev Med Pharmacol Sci. 2020 Nov;24(21):11295-11304 [PMID: 33215449]
  85. Arch Gerontol Geriatr. 2014 Nov-Dec;59(3):665-9 [PMID: 25081833]
  86. Spine (Phila Pa 1976). 2020 Apr 15;45(8):E457-E464 [PMID: 31651681]
  87. Curr Drug Metab. 2014;15(7):719-42 [PMID: 25429675]
  88. Bone. 2017 Apr;97:2-14 [PMID: 27989543]
  89. Sci Rep. 2016 May 20;6:26449 [PMID: 27197886]
  90. J Clin Invest. 2014 Jun;124(6):2585-98 [PMID: 24812669]
  91. Oxid Med Cell Longev. 2017;2017:5601593 [PMID: 28392887]
  92. Cancer Res. 2013 Mar 15;73(6):1993-2002 [PMID: 23333938]
  93. Osteoarthritis Cartilage. 2015 Jul;23(7):1057-70 [PMID: 25827971]
  94. Am J Pathol. 2021 Mar;191(3):487-502 [PMID: 33307037]
  95. J Orthop Res. 2018 May;36(5):1334-1345 [PMID: 29080374]
  96. Clin Chim Acta. 2015 Aug 25;448:238-46 [PMID: 26162271]
  97. Biosci Rep. 2019 Apr 2;39(4): [PMID: 30872412]
  98. Science. 2011 Nov 25;334(6059):1081-6 [PMID: 22116877]
  99. Anat Rec (Hoboken). 2015 Apr;298(4):720-6 [PMID: 25284686]
  100. Mol Cell. 2018 Aug 16;71(4):629-636.e5 [PMID: 30118681]
  101. Pain Pract. 2008 Jan-Feb;8(1):18-44 [PMID: 18211591]
  102. Apoptosis. 2011 Jun;16(6):594-605 [PMID: 21479580]
  103. J Cell Biol. 2006 Dec 18;175(6):901-11 [PMID: 17178908]
  104. FASEB J. 2020 Aug;34(8):10835-10849 [PMID: 32592441]
  105. Spine J. 2013 Mar;13(3):331-41 [PMID: 23369495]
  106. Biochem J. 1992 Jan 15;281 ( Pt 2):419-24 [PMID: 1310595]
  107. Front Cell Dev Biol. 2019 Jun 07;7:98 [PMID: 31231650]
  108. Cells. 2020 Dec 07;9(12): [PMID: 33297501]
  109. FEBS J. 2019 Nov;286(21):4356-4373 [PMID: 31230413]
  110. Appl Microbiol Biotechnol. 2020 Jul;104(14):6129-6140 [PMID: 32447438]
  111. Rev Neurosci. 2015;26(5):581-606 [PMID: 25996483]
  112. Science. 2009 Nov 27;326(5957):1216-9 [PMID: 19965464]
  113. Life Sci. 2017 Apr 15;175:1-10 [PMID: 28286226]
  114. Oxid Med Cell Longev. 2021 Mar 16;2021:8810698 [PMID: 33815661]
  115. J Orthop Translat. 2022 Jul 15;36:33-43 [PMID: 35891924]
  116. Biochem Pharmacol. 2022 Mar;197:114932 [PMID: 35085541]
  117. Int J Biochem Cell Biol. 2015 Apr;61:45-52 [PMID: 25660369]
  118. Pharmacol Res. 2017 Mar;117:357-369 [PMID: 28087442]
  119. Nature. 2016 Apr 21;532(7599):394-7 [PMID: 27007849]
  120. Nature. 1999 Jan 21;397(6716):271-4 [PMID: 9930704]
  121. Eur Spine J. 2011 Aug;20(8):1233-43 [PMID: 21336971]
  122. J Orthop Res. 2016 May;34(5):865-75 [PMID: 26505752]
  123. Life Sci. 2019 Jul 1;228:85-97 [PMID: 31047897]
  124. Cell Tissue Res. 2022 Oct;390(1):1-22 [PMID: 35792910]
  125. Mol Cell. 2004 Jul 2;15(1):95-105 [PMID: 15225551]
  126. J Biomed Sci. 2014 May 04;21:38 [PMID: 24884462]
  127. Mol Med Rep. 2022 May;25(5): [PMID: 35315493]
  128. J Cell Physiol. 2019 Aug;234(10):18192-18205 [PMID: 30854676]
  129. J Cell Sci. 2002 Feb 1;115(Pt 3):485-97 [PMID: 11861756]
  130. Sci Transl Med. 2018 May 2;10(439): [PMID: 29720449]
  131. Arthritis Res Ther. 2007;9(4):R77 [PMID: 17688691]
  132. Apoptosis. 2002 Aug;7(4):335-45 [PMID: 12101393]
  133. Neurosci Bull. 2016 Feb;32(1):61-9 [PMID: 26762342]
  134. Oxid Med Cell Longev. 2021 Mar 24;2021:6492879 [PMID: 33833850]
  135. Front Cell Dev Biol. 2022 Feb 01;9:819139 [PMID: 35178406]
  136. Ageing Res Rev. 2020 Jan;57:100978 [PMID: 31669486]
  137. Acta Neuropathol. 2017 Sep;134(3):489-506 [PMID: 28341998]
  138. Nat Rev Cancer. 2021 Feb;21(2):71-88 [PMID: 33214692]
  139. Nat Rev Mol Cell Biol. 2007 Jul;8(7):519-29 [PMID: 17565364]
  140. Mol Biol Cell. 2015 Aug 15;26(16):2873-84 [PMID: 26108623]
  141. Nat Rev Rheumatol. 2014 Sep;10(9):561-6 [PMID: 24914695]
  142. J Tissue Eng Regen Med. 2015 Oct;9(10):1120-32 [PMID: 24616324]
  143. Oxid Med Cell Longev. 2020 Dec 07;2020:6697577 [PMID: 33488928]
  144. Front Immunol. 2018 Aug 17;9:1706 [PMID: 30174670]
  145. Annu Rev Pathol. 2015;10:173-94 [PMID: 25387057]
  146. DNA Cell Biol. 2017 Aug;36(8):627-637 [PMID: 28622016]
  147. Cell Mol Life Sci. 2016 Jan;73(1):79-94 [PMID: 26433683]
  148. J Biol Chem. 2000 Nov 10;275(45):35098-105 [PMID: 11063750]
  149. Front Cell Dev Biol. 2021 Jun 07;9:675486 [PMID: 34164397]
  150. Mol Cell. 2000 May;5(5):897-904 [PMID: 10882126]
  151. Cell Mol Bioeng. 2015 Mar 1;8(1):51-62 [PMID: 25848407]
  152. Front Cell Dev Biol. 2021 Nov 04;9:745621 [PMID: 34805156]
  153. Rheumatology (Oxford). 2016 Nov;55(11):1993-2000 [PMID: 27498355]
  154. Oxid Med Cell Longev. 2021 Feb 10;2021:8884922 [PMID: 33628392]
  155. Trends Pharmacol Sci. 2018 Jul;39(7):610-623 [PMID: 29691058]
  156. Mol Aspects Med. 2018 Oct;63:18-29 [PMID: 29559224]
  157. J Cell Biol. 2009 Sep 21;186(6):783-92 [PMID: 19752026]

MeSH Term

Humans
Intervertebral Disc Degeneration
Apoptosis
Signal Transduction
Cellular Senescence
Endoplasmic Reticulum Stress
Journal Article Review Research Support, Non-U.S. Gov't
Article has an altmetric score of 1

Word Cloud

Created with Highcharts 10.0.0IDDdevelopmentstressERSreticulumdiscdegenerationEndoplasmicERvariouscellularmanyclinicalapoptosisintervertebralimportantplayerintracellularsignalingpathwaysregulatefunctionsdiseasesIntervertebralage-relateddegenerativediseaseonemaincauseslowbackpainAlthoughpathologicalfarfullyelucidatedstudiesshowninvolvedregulatesprocessesinflammationsenescenceexcessivemechanicalloadingmetabolicdisturbancesoxidativecalciumhomeostasisimbalanceextracellularmatrixECMdysregulationreviewsummarizesformationpotentiallinkcanpromisingnewtherapeutictargetmanagementassociatesATF6IRE1αPERKendoplasmic

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