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Clinical journal of the American Society of Nephrology : CJASN
01 01, 2023;18 (1): 60-71.

Global, Regional, and National Burden of CKD due to Glomerulonephritis from 1990 to 2019: A Systematic Analysis from the Global Burden of Disease Study 2019.

Junjie Hu, Runjiang Ke, Wilhem Teixeira, Yimin Dong, Rong Ding, Jincui Yang, Xing Ai, Da-Wei Ye, Jiwen Shang
Author Information
  1. Junjie Hu: Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  2. Runjiang Ke: Department of Urology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
  3. Wilhem Teixeira: Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  4. Yimin Dong: Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  5. Rong Ding: Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  6. Jincui Yang: Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  7. Xing Ai: Department of Urinary Surgery, The Seventh Medical Center of PLA General Hospital, Beijing, China.
  8. Da-Wei Ye: Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  9. Jiwen Shang: Department of Ambulatory Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Science, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, China.
PMID: 36719159 DOI: 10.2215/CJN.0000000000000017

Abstract

BACKGROUND: CKD is becoming a major human health concern. Limited quantitative assessments of the burden of CKD due to glomerulonephritis have been performed. We performed a comprehensive analysis of the disease burden to update the epidemiology of this disease.
METHODS: Incidence, prevalence, deaths, and disability-adjusted life-years (DALYs) data and percent changes in these indicators were extracted from Global Burden of Disease Study 2019 to analyze the burden of CKD due to glomerulonephritis.
RESULTS: Globally, there were 606,300 (95% uncertainty interval [UI], 560,100 to 658,100) incident patients, 17,300,000 (95% UI, 16,100,000 to 18,600,000) prevalent patients, 183,700 (95% UI, 146,300 to 228,900) deaths, and 6,900,000 (95% UI, 5,900,000 to 8,100,000) DALYs of CKD due to glomerulonephritis in 2019. Compared with those in 1990, the numbers of incident patients, prevalent patients, deaths, and DALYs increased by 77%, 81%, 100%, and 66%, respectively. Most of the disease burden was concentrated in countries with lower sociodemographic index. In Central Latin America, the disease burden was much higher than expected on the basis of its sociodemographic index. Decomposition analysis showed that population aging and growth were the two major drivers of the increase in DALYs. Frontier analysis revealed considerable opportunities to reduce the age-standardized DALYs in the middle of the sociodemographic-index spectrum. Although middle-aged and elderly individuals accounted for the majority of the disease burden, the highest incidence rate was observed in children aged 1-4 years.
CONCLUSIONS: The disease burden of CKD due to glomerulonephritis has increased worldwide, especially in regions and countries with lower sociodemographic indexes.

References

  1. Kidney Int. 2021 Jan;99(1):34-47 [PMID: 33127436]
  2. Kidney Int Suppl (2011). 2018 Feb;8(2):52-63 [PMID: 30675439]
  3. Popul Health Metr. 2012 Jan 06;10:1 [PMID: 22226226]
  4. Lancet. 2010 Jun 12;375(9731):2073-81 [PMID: 20483451]
  5. J Diabetes Investig. 2021 Mar;12(3):346-356 [PMID: 32654341]
  6. Lancet. 2017 Sep 16;390(10100):1211-1259 [PMID: 28919117]
  7. Lancet Public Health. 2021 Dec;6(12):e897-e906 [PMID: 34838196]
  8. Lancet. 2010 Apr 10;375(9722):1296-309 [PMID: 20382326]
  9. Lancet Respir Med. 2021 Sep;9(9):1030-1049 [PMID: 34411511]
  10. Lancet. 2017 Mar 25;389(10075):1238-1252 [PMID: 27887750]
  11. Int J Nephrol Renovasc Dis. 2020 Oct 22;13:261-272 [PMID: 33116757]
  12. Lancet. 2020 Feb 29;395(10225):709-733 [PMID: 32061315]
  13. Kidney Int. 2018 Sep;94(3):567-581 [PMID: 30078514]
  14. PLoS Med. 2006 Nov;3(11):e442 [PMID: 17132052]
  15. Pediatr Clin North Am. 2009 Dec;56(6):1363-82 [PMID: 19962026]
  16. Lancet. 2018 Nov 10;392(10159):1995-2051 [PMID: 30496106]
  17. Lancet. 2013 Jul 20;382(9888):260-72 [PMID: 23727169]
  18. Front Endocrinol (Lausanne). 2021 Jul 01;12:672350 [PMID: 34276558]
  19. Lancet. 2018 Nov 10;392(10159):2052-2090 [PMID: 30340847]
  20. Nephron. 1990;55(1):1-5 [PMID: 2191230]
  21. Front Med (Lausanne). 2021 Jun 21;8:690487 [PMID: 34235163]
  22. BMJ. 2020 Mar 26;368:m791 [PMID: 32217608]
  23. Lancet. 2020 Oct 17;396(10258):1160-1203 [PMID: 33069325]
  24. Pediatr Nephrol. 2012 Mar;27(3):363-73 [PMID: 21713524]
  25. Lancet. 2020 Oct 17;396(10258):1204-1222 [PMID: 33069326]
  26. Ann Intern Med. 2013 Jun 4;158(11):825-30 [PMID: 23732715]

MeSH Term

Aged
Middle Aged
Child
Humans
Global Burden of Disease
Quality-Adjusted Life Years
Persons with Disabilities
Cost of Illness
Incidence
Prevalence
Renal Insufficiency, Chronic
Global Health
Journal Article
Article has an altmetric score of 20

Word Cloud

Created with Highcharts 10.0.0burdenCKDdisease000dueDALYsglomerulonephritis95%100patientsanalysisdeathsGlobalBurden2019300UI900sociodemographicmajorperformedDiseaseStudyincidentprevalent1990increasedcountrieslowerindexBACKGROUND:becominghumanhealthconcernLimitedquantitativeassessmentscomprehensiveupdateepidemiologyMETHODS:Incidenceprevalencedisability-adjustedlife-yearsdatapercentchangesindicatorsextractedanalyzeRESULTS:Globally606uncertaintyinterval[UI]560658171618600183700146228658Comparednumbers77%81%100%66%respectivelyconcentratedCentralLatinAmericamuchhigherexpectedbasisDecompositionshowedpopulationaginggrowthtwodriversincreaseFrontierrevealedconsiderableopportunitiesreduceage-standardizedmiddlesociodemographic-indexspectrumAlthoughmiddle-agedelderlyindividualsaccountedmajorityhighestincidencerateobservedchildrenaged1-4yearsCONCLUSIONS:worldwideespeciallyregionsindexesRegionalNationalGlomerulonephritis2019:SystematicAnalysis

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