Combination venetoclax and olverembatinib (HQP1351) as a successful therapeutic strategy for relapsed/refractory (R/R) mixed-phenotype blast phase of chronic myeloid leukemia.

Tongtong Zhang, Haixia Zhou, Mingzhu Xu, Chongsheng Qian, Aining Sun, Depei Wu, Shengli Xue
Author Information
  1. Tongtong Zhang: Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, 215000, China. ORCID
  2. Haixia Zhou: Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, 215000, China.
  3. Mingzhu Xu: Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, 215000, China.
  4. Chongsheng Qian: Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, 215000, China.
  5. Aining Sun: Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, 215000, China.
  6. Depei Wu: Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, 215000, China.
  7. Shengli Xue: Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, 215000, China. slxue@suda.edu.cn.

Abstract

No abstract text available.

References

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  2. Jiang Q, Li Z, Qin Y et al (2022) Olverembatinib (HQP1351), a well-tolerated and effective tyrosine kinase inhibitor for patients with T315I-mutated chronic myeloid leukemia: results of an open-label, multicenter phase 1/2 trial. J Hematol Oncol 15(1):113 [DOI: 10.1186/s13045-022-01334-z]
  3. Dhillon S (2022) Olverembatinib: First Approval. Drugs 82(4):469–475 [DOI: 10.1007/s40265-022-01680-9]
  4. Liu X, Wang G, Yan X et al (2019) Preclinical development of HQP1351, a multikinase inhibitor targeting a broad spectrum of mutant KIT kinases, for the treatment of imatinib-resistant gastrointestinal stromal tumors. Cell Biosci 9:88 [DOI: 10.1186/s13578-019-0351-6]
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  7. Short NJ, Konopleva M, Kadia T et al (2021) An effective chemotherapy-free regimen of ponatinib plus venetoclax for relapsed/refractory Philadelphia chromosome-positive acute lymphoblastic leukemia. Am J Hematol 96(7):E229–E232 [DOI: 10.1002/ajh.26175]
  8. Maiti A, Franquiz MJ, Ravandi F et al (2020) Venetoclax and BCR-ABL tyrosine kinase inhibitor combinations: outcome in patients with Philadelphia chromosome-positive advanced myeloid leukemias. Acta Haematol 143(6):567–573 [DOI: 10.1159/000506346]
  9. Fang DD, Zhu H, Tang Q et al (2021) FLT3 inhibition by olverem batinib (HQP1351) downregulates MCL-1 and synergizes with BCL-2 inhibitor lisaftoclax (APG-2575) in preclinical models of FLT3-ITD mutant acute myeloid leukemia. Transl Oncol 15(1):101244 [DOI: 10.1016/j.tranon.2021.101244]
  10. Wang N, He J, Liu F (2022) Venetoclax in combination with hypomethylating agents for the treatment of treatment-naive B/myeloid mixed-phenotype acute leukemia and relapsed/refractory acute myeloid leukemia: a report of 3 cases. Chemotherapy 67(3):178–182 [DOI: 10.1159/000519882]

Grants

  1. 81970138/National Natural Science Foundation of China
  2. 81900130/National Natural Science Foundation of China
  3. 2020ZKMB05/Translational Research Grant of NCRCH
  4. BE2021649/Social Development Project of the Science and Technology Department of Jiangsu
  5. GSWS2019007/Gusu Key Medical Talent Program

MeSH Term

Humans
Blast Crisis
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Leukemia, Myeloid
Bridged Bicyclo Compounds, Heterocyclic
Antineoplastic Combined Chemotherapy Protocols
Leukemia, Myeloid, Acute

Chemicals

venetoclax
olverembatinib
Bridged Bicyclo Compounds, Heterocyclic