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Journal of clinical medicine
Jan 30, 2023;12 (3):

Clinical Factors Associated with Arterial Stiffness in Chronic Kidney Disease.

Jin Yao, Zheyi Dong, Qian Wang, Zhe Li, Weiguang Zhang, Wenwen Lin, Yayong Luo, Hangtian Li, Xinru Guo, Li Zhang, Guangyan Cai, Wanjun Shen, Shuwei Duan, Xiangmei Chen
Author Information
  1. Jin Yao: School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China. ORCID
  2. Zheyi Dong: Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing 100853, China.
  3. Qian Wang: Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing 100853, China.
  4. Zhe Li: Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing 100853, China.
  5. Weiguang Zhang: Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing 100853, China.
  6. Wenwen Lin: School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China.
  7. Yayong Luo: School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China. ORCID
  8. Hangtian Li: School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China. ORCID
  9. Xinru Guo: Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing 100853, China.
  10. Li Zhang: Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing 100853, China.
  11. Guangyan Cai: Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing 100853, China.
  12. Wanjun Shen: Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing 100853, China.
  13. Shuwei Duan: Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing 100853, China.
  14. Xiangmei Chen: School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China.
PMID: 36769724 DOI: 10.3390/jcm12031077

Abstract

BACKGROUND: Arterial stiffness influences the prognosis of patients with end-stage kidney disease; however, the factors that promote arterial stiffness in chronic kidney disease (CKD) patients remain unknown. We aimed to explore the clinical factors associated with arterial stiffness in CKD.
METHODS: Between September 2017 and September 2022, all CKD patients treated at the Department of Nephrology, General Hospital of the Chinese People's Liberation Army, excluding dialysis patients, were screened and their medical records within the last month were collected. Arterial stiffness was measured by the augmentation index (AIx). The correlative clinical factors with arterial stiffness were explored in different linear regression models.
RESULTS: 559 patients were included in the study. AIx@75 increased as the deterioration of CKDG1-CKDG5, with values of 1 (-9, 11), 5.5 (-4, 13.25), 9 (0, 16), 12 (1.5, 23.5), and 22 (13, 28), respectively (Z = 63.03, < 0.001). Multivariate linear regression analysis showed that AIx@75 was positively associated with female sex (β = 8.926, 95% confidence interval (CI) 6.291, 11.562, < 0.001), age (β = 0. 485, 95% CI 0.39, 0.58, < 0.001), mean arterial pressure (MAP) (β = 0.255, 95% CI 0.159, 0.35, < 0.001), and was negatively associated with ACEI/ARB (β = -4.466, 95% CI -6.963, -1.969, < 0.001) and glucocorticoid (β = -3.163, 95% CI -6.143, -0.183, = 0.038). Smoking, eGFR, hemoglobin, and cause of disease were associated with AIx@75 in multivariate linear regression models when considering factors partly.
CONCLUSIONS: Female, age, smoking, MAP, eGFR, cause of disease, ACEI/ARB, and glucocorticoid were found to be associated with atherosclerosis in CKD patients.

Keywords

arterial stiffness augmentation index chronic kidney disease

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Grants

  1. No. 32141005/the National Natural Science Foundation of China
  2. No. D181100000118002/the Science and Technology Project of Beijing, China
  3. No.2019YFC1709903/the National Key Research and Development Program of China
Journal Article

Word Cloud

Created with Highcharts 10.0.00=stiffnesspatientsdiseasearterialassociated<001β95%CIfactorsCKD5ArterialkidneylinearregressionAIx@75chronicclinicalSeptemberaugmentationindexmodels111-413ageMAPACEI/ARB-6glucocorticoideGFRcauseBACKGROUND:influencesprognosisend-stagehoweverpromoteremainunknownaimedexploreMETHODS:20172022treatedDepartmentNephrologyGeneralHospitalChinesePeople'sLiberationArmyexcludingdialysisscreenedmedicalrecordswithinlastmonthcollectedmeasuredAIxcorrelativeexploreddifferentRESULTS:559includedstudyincreaseddeteriorationCKDG1-CKDG5values-92591612232228respectivelyZ6303Multivariateanalysisshowedpositivelyfemalesex8926confidenceinterval62915624853958meanpressure25515935negatively466963-1969-3163143-0183038SmokinghemoglobinmultivariateconsideringpartlyCONCLUSIONS:FemalesmokingfoundatherosclerosisClinicalFactorsAssociatedStiffnessChronicKidneyDisease

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