Structural Insights for β-Lactam Antibiotics. - National Genomics Data Center (CNCB-NGDC)

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Structural Insights for β-Lactam Antibiotics.

Dogyeoung Kim, Sumin Kim, Yongdae Kwon, Yeseul Kim, Hyunjae Park, Kiwoong Kwak, Hyeonmin Lee, Jung Hun Lee, Kyung-Min Jang, Donghak Kim, Sang Hee Lee, Lin-Woo Kang

Author Information

Dogyeoung Kim: Department of Biological Sciences, Konkuk University, Seoul 05029, Republic of Korea.
Sumin Kim: Department of Biological Sciences, Konkuk University, Seoul 05029, Republic of Korea.
Yongdae Kwon: Department of Biological Sciences, Konkuk University, Seoul 05029, Republic of Korea.
Yeseul Kim: Department of Biological Sciences, Konkuk University, Seoul 05029, Republic of Korea.
Hyunjae Park: Department of Biological Sciences, Konkuk University, Seoul 05029, Republic of Korea.
Kiwoong Kwak: Department of Biological Sciences, Konkuk University, Seoul 05029, Republic of Korea.
Hyeonmin Lee: Department of Biological Sciences, Konkuk University, Seoul 05029, Republic of Korea.
Jung Hun Lee: National Leading Research Laboratory of Drug Resistance Proteomics, Department of Biological Sciences, Myongji University, Yongin 17058, Republic of Korea.
Kyung-Min Jang: National Leading Research Laboratory of Drug Resistance Proteomics, Department of Biological Sciences, Myongji University, Yongin 17058, Republic of Korea.
Donghak Kim: Department of Biological Sciences, Konkuk University, Seoul 05029, Republic of Korea.
Sang Hee Lee: National Leading Research Laboratory of Drug Resistance Proteomics, Department of Biological Sciences, Myongji University, Yongin 17058, Republic of Korea.
Lin-Woo Kang: Department of Biological Sciences, Konkuk University, Seoul 05029, Republic of Korea.

PMID: 36788654 DOI: 10.4062/biomolther.2023.008

Antibiotic resistance has emerged as a global threat to modern healthcare systems and has nullified many commonly used antibiotics. β-Lactam antibiotics are among the most successful and occupy approximately two-thirds of the prescription antibiotic market. They inhibit the synthesis of the peptidoglycan layer in the bacterial cell wall by mimicking the D-Ala-D-Ala in the pentapeptide crosslinking neighboring glycan chains. To date, various β-lactam antibiotics have been developed to increase the spectrum of activity and evade drug resistance. This review emphasizes the three-dimensional structural characteristics of β-lactam antibiotics regarding the overall scaffold, working mechanism, chemical diversity, and hydrolysis mechanism by β-lactamases. The structural insight into various β-lactams will provide an in-depth understanding of the antibacterial efficacy and susceptibility to drug resistance in multidrug-resistant bacteria and help to develop better β-lactam antibiotics and inhibitors.

Antibiotic resistance Antibiotics Metallo-β-lactamases Peptidoglycan Serine β-lactamases β-Lactams

Nat Rev Microbiol. 2019 May;17(5):295-306 [PMID: 30837684]
Chem Rev. 2021 Jul 14;121(13):7957-8094 [PMID: 34129337]
PLoS One. 2015 Feb 17;10(2):e0117874 [PMID: 25689853]
Mol Biol Rep. 2020 Aug;47(8):6281-6294 [PMID: 32654052]
Cold Spring Harb Perspect Med. 2016 Dec 1;6(12): [PMID: 27599531]
FEMS Microbiol Rev. 2008 Mar;32(2):149-67 [PMID: 18194336]
Antimicrob Agents Chemother. 2018 Dec 21;63(1): [PMID: 30348667]
Lancet Infect Dis. 2016 Jan;16(1):17-18 [PMID: 26738826]
Nat Rev Microbiol. 2015 May;13(5):310-7 [PMID: 25817583]
PLoS Med. 2016 Nov 29;13(11):e1002184 [PMID: 27898664]
Int J Mol Sci. 2020 Jul 12;21(14): [PMID: 32664695]
Microbiol Mol Biol Rev. 1998 Dec;62(4):1079-93 [PMID: 9841666]
J Am Chem Soc. 2009 Oct 14;131(40):14345-54 [PMID: 19807181]
J Enzyme Inhib Med Chem. 2017 Dec;32(1):917-919 [PMID: 28719998]
Lancet Infect Dis. 2013 Dec;13(12):1057-98 [PMID: 24252483]
Molecules. 2020 Mar 16;25(6): [PMID: 32187986]
Pathogens. 2021 Oct 12;10(10): [PMID: 34684258]
Curr Opin Infect Dis. 2020 Apr;33(2):214-223 [PMID: 32068644]
Nat Rev Microbiol. 2015 Jan;13(1):42-51 [PMID: 25435309]
Immunohorizons. 2021 Jun 28;5(6):512-522 [PMID: 34183380]
Med Res Rev. 2020 Sep;40(5):1558-1592 [PMID: 32100311]
FEMS Microbiol Rev. 2008 Mar;32(2):234-58 [PMID: 18266856]
Sci Rep. 2017 Jan 11;7:40357 [PMID: 28074907]
Acc Chem Res. 2006 Oct;39(10):721-8 [PMID: 17042472]
J Mol Biol. 2007 Aug 10;371(2):528-39 [PMID: 17582436]

Journal Article Review

β-Lactam Antibiotics Renaissance.Allergy to β-lactam antibiotics.Skin testing with β-lactam antibiotics for diagnosis of β-lactam hypersensitivity in children.[Therapeutic drug monitoring of β-lactam antibiotics].Could β-Lactam Antibiotics Block Humoral Immunity?Hypersensitivity to non-β-lactam antibiotics.Overcoming resistance to β-lactam antibiotics.Occupational allergy to β-lactam antibiotics.Convergent biosynthetic pathways to β-lactam antibiotics.Inoculum effect of β-lactam antibiotics.

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