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European journal of applied physiology
Jun, 2023;123 (6): 1323-1342.

The benefits of regular aerobic exercise training on cerebrovascular function and cognition in older adults.

Edward S Bliss, Samia M Biki, Rachel H X Wong, Peter R C Howe, Dean E Mills
Author Information
  1. Edward S Bliss: Respiratory and Exercise Physiology Research Group, School of Health and Medical Sciences, University of Southern Queensland, Toowoomba Campus, 11 Salisbury Rd, Ipswich, QLD, 4305, Australia. Edward.Bliss@usq.edu.au. ORCID
  2. Samia M Biki: Respiratory and Exercise Physiology Research Group, School of Health and Medical Sciences, University of Southern Queensland, Toowoomba Campus, 11 Salisbury Rd, Ipswich, QLD, 4305, Australia.
  3. Rachel H X Wong: Centre for Health Research, Institute for Resilient Regions, University of Southern Queensland, Ipswich, QLD, Australia.
  4. Peter R C Howe: Centre for Health Research, Institute for Resilient Regions, University of Southern Queensland, Ipswich, QLD, Australia.
  5. Dean E Mills: Respiratory and Exercise Physiology Research Group, School of Health and Medical Sciences, University of Southern Queensland, Toowoomba Campus, 11 Salisbury Rd, Ipswich, QLD, 4305, Australia.
PMID: 36801969 DOI: 10.1007/s00421-023-05154-y

Abstract

We compared the differences in cerebrovascular and cognitive function between 13 aerobic exercise trained, older adults and 13 age-, height- and sex-matched sedentary, untrained controls. We determined whether other measures accounted for differences in cerebrovascular and cognitive function between these groups and examined the associations between these functions. Participants undertook anthropometric, mood, cardiovascular, exercise performance, strength, cerebrovascular, and cognitive measurements, and a blood collection. Transcranial Doppler ultrasonography determined cerebrovascular responsiveness (CVR) to hypercapnia and cognitive stimuli. The trained group had a higher CVR to hypercapnia (80.3 ± 7.2 vs 35.1 ± 6.7%, P < 0.001), CVR to cognitive stimuli (30.1 ± 2.9 vs 17.8 ± 1.4%, P = 0.001) and total composite cognitive score (117 ± 2 vs 98 ± 4, P < 0.001) than the controls. These parameters no longer remained statistically different between the groups following adjustments for covariates. There were positive correlations between the total composite cognitive score and CVR to hypercapnia (r = 0.474, P = 0.014) and CVR to cognitive stimuli (r = 0.685, P < 0.001). We observed a relationship between cerebrovascular and cognitive function in older adults and an interaction between regular lifelong aerobic exercise training and cardiometabolic factors that may directly influence these functions.

Keywords

Aerobic exercise training Ageing Cardiometabolic Cerebrovascular function Cognition

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MeSH Term

Humans
Aged
Hypercapnia
Cognition
Exercise
Cerebrovascular Circulation
Journal Article
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