Validation of depression determinants in caregivers of dementia patients with machine learning algorithms and statistical model.

Kangrim Cho, Junggu Choi, Sanghoon Han
Author Information
  1. Kangrim Cho: Yonsei Graduate Program in Cognitive Science, Yonsei University, Seoul, Republic of Korea.
  2. Junggu Choi: Yonsei Graduate Program in Cognitive Science, Yonsei University, Seoul, Republic of Korea.
  3. Sanghoon Han: Yonsei Graduate Program in Cognitive Science, Yonsei University, Seoul, Republic of Korea.

Abstract

Introduction: Due to its increasing prevalence, dementia is currently one of the most extensively studied health issues. Although it represents a comparatively less-addressed issue, the caregiving burden for dementia patients is likewise receiving attention.
Methods: To identify determinants of depression in dementia caregivers, using Community Health Survey (CHS) data collected by the Korea Disease Control and Prevention Agency (KDCA). By setting "dementia caregiver's status of residence with patient" as a standard variable, we selected corresponding CHS data from 2011 to 2019. After refining the data, we split dementia caregiver and general population groups among the dataset ( = 15,708; common variables = 34). We then applied three machine learning algorithms: Extreme Gradient Boosting (XGBoost), Logistic Regression (LR), and Support Vector Classifier (SVC). Subsequently, we selected XGBoost, as it exhibited superior performance to the other algorithms. On the feature importance of XGBoost, we performed a multivariate hierarchical regression analysis to validate the depression causes experienced in each group. We validated the results of the statistical model analysis by performing Welch's -test on the main determinants exhibited within each group.
Results: By verifying the results from machine learning statistical model analysis, we found "sex" to highly impact depression in dementia caregivers, whereas "status of economic activities" is significantly associated with depression in the general population.
Discussion: The evident difference in causes of depression between the two groups may serve as a basis for policy development to improve the mental health of dementia caregivers.

Keywords

References

  1. J Epidemiol Community Health. 2010 May;64(5):447-52 [PMID: 19679710]
  2. BMJ Glob Health. 2022 Apr;7(4): [PMID: 35379735]
  3. Am J Geriatr Psychiatry. 2014 May;22(5):481-8 [PMID: 23567432]
  4. Acta Psychiatr Scand. 2003 Feb;107(2):132-41 [PMID: 12534439]
  5. Arch Intern Med. 2003 Sep 22;163(17):2058-65 [PMID: 14504119]
  6. Int J Geriatr Psychiatry. 2011 Oct;26(10):1089-98 [PMID: 21308785]
  7. Am J Epidemiol. 1991 Jul 15;134(2):220-31 [PMID: 1862805]
  8. Ir J Med Sci. 2011 Jun;180(2):319-25 [PMID: 21076975]
  9. J Biomed Inform. 2002 Oct-Dec;35(5-6):352-9 [PMID: 12968784]
  10. Lancet Neurol. 2019 Jan;18(1):88-106 [PMID: 30497964]
  11. Gerontology. 2009;55(1):106-13 [PMID: 19023194]
  12. J Appl Gerontol. 2021 Jul;40(7):703-712 [PMID: 32854567]
  13. J Health Soc Behav. 1992 Sep;33(3):187-205; discussion 206-12 [PMID: 1401846]
  14. JMIR Med Inform. 2020 Apr 30;8(4):e15516 [PMID: 32352387]
  15. J Adv Nurs. 2012 Apr;68(4):846-55 [PMID: 21793872]
  16. Neurol Sci. 2009 Apr;30(2):171-4 [PMID: 19189044]
  17. Lancet Public Health. 2022 Feb;7(2):e105-e125 [PMID: 34998485]
  18. Age Ageing. 2010 Jan;39(1):23-30 [PMID: 19903775]
  19. PLoS One. 2020 Apr 20;15(4):e0231848 [PMID: 32310969]
  20. Sultan Qaboos Univ Med J. 2015 Feb;15(1):e4-6 [PMID: 25685384]
  21. Front Psychol. 2020 Nov 05;11:586202 [PMID: 33240178]
  22. Asia Pac J Public Health. 2023 Mar;35(2-3):214-216 [PMID: 36872615]
  23. Community Dent Oral Epidemiol. 2012 Apr;40(2):134-44 [PMID: 21883356]
  24. Int J Geriatr Psychiatry. 1997 Mar;12(3):331-6 [PMID: 9152717]
  25. J Am Coll Health. 2016 Jul;64(5):362-70 [PMID: 26943354]
  26. BMC Public Health. 2016 Aug 24;16(1):863 [PMID: 27558007]
  27. Gerontologist. 2019 Sep 17;59(5):e512-e520 [PMID: 31322654]
  28. Clin Oral Investig. 2018 Nov;22(8):2685-2702 [PMID: 30191327]
  29. J Health Soc Behav. 2000 Dec;41(4):421-36 [PMID: 11198566]
  30. BMJ Open. 2020 Feb 28;10(2):e033109 [PMID: 32114464]
  31. JAMA Netw Open. 2019 Aug 2;2(8):e199891 [PMID: 31441938]

Word Cloud

Created with Highcharts 10.0.0dementiadepressioncaregiversmachinelearningstatisticalmodelhealthdeterminantsdataXGBoostanalysispatientsCHSselectedcaregivergeneralpopulationgroups=exhibitedalgorithmscausesgroupresultsIntroduction:DueincreasingprevalencecurrentlyoneextensivelystudiedissuesAlthoughrepresentscomparativelyless-addressedissuecaregivingburdenlikewisereceivingattentionMethods:identifyusingCommunityHealthSurveycollectedKoreaDiseaseControlPreventionAgencyKDCAsetting"dementiacaregiver'sstatusresidencepatient"standardvariablecorresponding20112019refiningsplitamongdataset15708commonvariables34appliedthreealgorithms:ExtremeGradientBoostingLogisticRegressionLRSupportVectorClassifierSVCSubsequentlysuperiorperformancefeatureimportanceperformedmultivariatehierarchicalregressionvalidateexperiencedvalidatedperformingWelch's-testmainwithinResults:verifyingfound"sex"highlyimpactwhereas"statuseconomicactivities"significantlyassociatedDiscussion:evidentdifferencetwomayservebasispolicydevelopmentimprovementalValidationcommunitysurvey

Similar Articles

Cited By