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Jan 28, 2023;11 (2):

An Overview of Physiologically-Based Pharmacokinetic Models for Forensic Science.

Kiara Fairman, Me-Kyoung Choi, Pavani Gonnabathula, Annie Lumen, Andrew Worth, Alicia Paini, Miao Li
Author Information
  1. Kiara Fairman: Division of Biochemical Toxicology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, AR 72079, USA.
  2. Me-Kyoung Choi: Division of Biochemical Toxicology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, AR 72079, USA.
  3. Pavani Gonnabathula: Division of Biochemical Toxicology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, AR 72079, USA.
  4. Annie Lumen: Division of Biochemical Toxicology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, AR 72079, USA.
  5. Andrew Worth: European Commission, Joint Research Centre (JRC), 21027 Ispra, Italy. ORCID
  6. Alicia Paini: esqLABS GmbH, 26683 Saterland, Germany. ORCID
  7. Miao Li: Division of Biochemical Toxicology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, AR 72079, USA.
PMID: 36851001 DOI: 10.3390/toxics11020126

Abstract

A physiologically-based pharmacokinetic (PBPK) model represents the structural components of the body with physiologically relevant compartments connected via blood flow rates described by mathematical equations to determine drug disposition. PBPK models are used in the pharmaceutical sector for drug development, precision medicine, and the chemical industry to predict safe levels of exposure during the registration of chemical substances. However, one area of application where PBPK models have been scarcely used is forensic science. In this review, we give an overview of PBPK models successfully developed for several illicit drugs and environmental chemicals that could be applied for forensic interpretation, highlighting the gaps, uncertainties, and limitations.

Keywords

PBPK model exposure illicit drug post-mortem redistribution substance of abuse

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Created with Highcharts 10.0.0PBPKdrugmodelsmodelusedchemicalexposureforensicillicitphysiologically-basedpharmacokineticrepresentsstructuralcomponentsbodyphysiologicallyrelevantcompartmentsconnectedviabloodflowratesdescribedmathematicalequationsdeterminedispositionpharmaceuticalsectordevelopmentprecisionmedicineindustrypredictsafelevelsregistrationsubstancesHoweveroneareaapplicationscarcelysciencereviewgiveoverviewsuccessfullydevelopedseveraldrugsenvironmentalchemicalsappliedinterpretationhighlightinggapsuncertaintieslimitationsOverviewPhysiologically-BasedPharmacokineticModelsForensicSciencepost-mortemredistributionsubstanceabuse

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