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02 18, 2023;15 (2):

The Host Non-Coding RNA Response to Alphavirus Infection.

Mahgol Behnia, Steven B Bradfute
Author Information
  1. Mahgol Behnia: Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA. ORCID
  2. Steven B Bradfute: Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA. ORCID
PMID: 36851776 DOI: 10.3390/v15020562

Abstract

Alphaviruses are important human and animal pathogens that can cause a range of debilitating symptoms and are found worldwide. These include arthralgic diseases caused by Old-World viruses and encephalitis induced by infection with New-World alphaviruses. Non-coding RNAs do not encode for proteins, but can modulate cellular response pathways in a myriad of ways. There are several classes of non-coding RNAs, some more well-studied than others. Much research has focused on the mRNA response to infection against alphaviruses, but analysis of non-coding RNA responses has been more limited until recently. This review covers what is known regarding host cell non-coding RNA responses in alphavirus infections and highlights gaps in the knowledge that future research should address.

Keywords

RNA alphavirus chikungunya encephalitis lncRNA miRNA noncoding snoRNA

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MeSH Term

Animals
Humans
Alphavirus Infections
Alphavirus
Arthralgia
Encephalitis
RNA, Untranslated

Chemicals

RNA, Untranslated
Journal Article Review Research Support, U.S. Gov't, Non-P.H.S.
Article has an altmetric score of 3

Word Cloud

Created with Highcharts 10.0.0RNAnon-codingcanencephalitisinfectionalphavirusesRNAsresponseresearchresponsesalphavirusAlphavirusesimportanthumananimalpathogenscauserangedebilitatingsymptomsfoundworldwideincludearthralgicdiseasescausedOld-WorldvirusesinducedNew-WorldNon-codingencodeproteinsmodulatecellularpathwaysmyriadwaysseveralclasseswell-studiedothersMuchfocusedmRNAanalysislimitedrecentlyreviewcoversknownregardinghostcellinfectionshighlightsgapsknowledgefutureaddressHostNon-CodingResponseAlphavirusInfectionchikungunyalncRNAmiRNAnoncodingsnoRNA

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