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Phytotherapy research : PTR
May, 2023;37 (5): 2051-2066.

Berberine and health outcomes: An umbrella review.

Zhongyu Li, Yang Wang, Qing Xu, Jinxin Ma, Xuan Li, Jiaxing Yan, Yibing Tian, Yandong Wen, Ting Chen
Author Information
  1. Zhongyu Li: Department of Gastroenterology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China. ORCID
  2. Yang Wang: Department of Gastroenterology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China. ORCID
  3. Qing Xu: Department of Gastroenterology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China. ORCID
  4. Jinxin Ma: Department of Gastroenterology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China. ORCID
  5. Xuan Li: Department of Gastroenterology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China. ORCID
  6. Jiaxing Yan: Department of Gastroenterology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China. ORCID
  7. Yibing Tian: Department of Gastroenterology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China. ORCID
  8. Yandong Wen: Department of Chinese Medicine, Eye Hospital, China Academy of Chinese Medical Sciences, Beijing, China. ORCID
  9. Ting Chen: Department of Gastroenterology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China. ORCID
PMID: 36999891 DOI: 10.1002/ptr.7806

Abstract

Berberine is a plant extract widely used in clinical practice. This review aimed to summarize and to grade the available evidence on the association between berberine consumption and health-related outcomes. The PubMed, Cochrane Library, and Embase databases were searched for meta-analyses of randomized controlled trials (RCTs) assessing the efficacy and safety of berberine from inception to June 30, 2022. The AMSTAR-2 and GRADE system were used to assess the methodological quality and evidence level of the included meta-analyses. A total of 11 eligible meta-analyses were identified from 235 publications, which were published in peer-reviewed journals between 2013 and 2022. The results revealed that berberine significantly affects blood glucose levels, insulin resistance, blood lipids, body parameters and composition, inflammatory markers, colorectal adenomas, and Helicobacter pylori infections as compared to controls. Common side effects of berberine consumption include gastrointestinal symptoms, such as constipation and diarrhea. Berberine is a safe medicinal plant ingredient that improves various clinical outcomes; however, there is a need for improvement of methodological quality in published meta-analyses. Additionally, the clinical effects of berberine need to be confirmed in high-quality RCTs.

Keywords

AMSTAR-2 berberine health outcomes meta-analysis

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Grants

  1. 8207153155/National Natural Science Foundation of China
  2. CI2021A01005/Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences

MeSH Term

Humans
Berberine
Lipids
Constipation
Colorectal Neoplasms

Chemicals

Berberine
Lipids
Journal Article Systematic Review
Article has an altmetric score of 15

Word Cloud

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