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International journal of molecular sciences
Mar 28, 2023;24 (7):

The Role of Adipokines in the Pathogenesis of Psoriasis.

Kajetan Kiełbowski, Estera Bakinowska, Piotr Ostrowski, Bartłomiej Pala, Ewa Gromowska, Klaudia Gurazda, Paweł Dec, Andrzej Modrzejewski, Andrzej Pawlik
Author Information
  1. Kajetan Kiełbowski: Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland. ORCID
  2. Estera Bakinowska: Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland.
  3. Piotr Ostrowski: Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland. ORCID
  4. Bartłomiej Pala: Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland.
  5. Ewa Gromowska: Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland.
  6. Klaudia Gurazda: Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland.
  7. Paweł Dec: Plastic and Reconstructive Surgery Department, 109 Military Hospital, 71-422 Szczecin, Poland. ORCID
  8. Andrzej Modrzejewski: Department of Surgery, Pomeranian Medical University, 71-422 Szczecin, Poland.
  9. Andrzej Pawlik: Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland. ORCID
PMID: 37047363 DOI: 10.3390/ijms24076390

Abstract

Psoriasis is a chronic and immune-mediated skin condition characterized by pro-inflammatory cytokines and keratinocyte hyperproliferation. Dendritic cells, T lymphocytes, and keratinocytes represent the main cell subtypes involved in the pathogenesis of psoriasis, while the interleukin-23 (IL-23)/IL-17 pathway enhances the disease progression. Human adipose tissue is an endocrine organ, which secretes multiple proteins, known as adipokines, such as adiponectin, leptin, visfatin, or resistin. Current evidence highlights the immunomodulatory roles of adipokines, which may contribute to the progression or suppression of psoriasis. A better understanding of the complexity of psoriasis pathophysiology linked with adipokines could result in developing novel diagnostic or therapeutic strategies. This review aims to present the pathogenesis of psoriasis and the roles of adipokines in this process.

Keywords

adipokines adiponectin cytokines inflammation leptin psoriasis

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MeSH Term

Humans
Adipokines
Leptin
Psoriasis
Resistin
Adiponectin
Adipose Tissue

Chemicals

Adipokines
Leptin
Resistin
Adiponectin
Journal Article Review
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