In an era of antibiotic resistance where natural antibiotic substitutes are considered essential, the antimicrobial and antibiofilm activities of extract on strains of pathogenic isolated from pork were evaluated. The strains which form biofilms were more resistant (MIC = 2.5 mgml) compared to non-biofilm forming strains (MIC = 1.25 mgml). Use of extract at 20 mgml concentration has resulted in inhibition of biofilm formation by 53.96%. Cyclobarbital, 5, 8-dimethoxycumarin, orotic acid and 3-methylsalicylhydrazide were the major phytochemicals in extract with highest docking affinities against the biofilm associated proteins in . The results of simulation studies have clearly illustrated the energy stability of the protein-ligand complexes. Absorption, distribution, metabolism, excretion and toxicity (ADMET) profiles revealed that the phytochemicals in could be used in the drug design studies to preferentially target the specific receptors to combat biofilms associated with
