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Frontiers in neuroscience
2023;17 1132393.

DTI-ALPS: An MR biomarker for motor dysfunction in patients with subacute ischemic stroke.

Yue Qin, Xin Li, Yanqiang Qiao, Huili Zou, Yifan Qian, Xiaoshi Li, Yinhu Zhu, Wenli Huo, Lei Wang, Ming Zhang
Author Information
  1. Yue Qin: Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  2. Xin Li: Department of Radiology, Xi'an Daxing Hospital, Xi'an, China.
  3. Yanqiang Qiao: Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  4. Huili Zou: Department of Rehabilitation Medicine, Xi'an Daxing Hospital, Xi'an, China.
  5. Yifan Qian: Department of Radiology, Xi'an Daxing Hospital, Xi'an, China.
  6. Xiaoshi Li: Department of Radiology, Xi'an Daxing Hospital, Xi'an, China.
  7. Yinhu Zhu: Department of Radiology, Xi'an Daxing Hospital, Xi'an, China.
  8. Wenli Huo: Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  9. Lei Wang: Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  10. Ming Zhang: Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
PMID: 37065921 DOI: 10.3389/fnins.2023.1132393

Abstract

Purpose: Brain glymphatic dysfunction is involved in the pathologic process of acute ischemic stroke (IS). The relationship between brain glymphatic activity and dysfunction in subacute IS has not been fully elucidated. Diffusion tensor image analysis along the perivascular space (DTI-ALPS) index was used in this study to explore whether glymphatic activity was related to motor dysfunction in subacute IS patients.
Methods: Twenty-six subacute IS patients with a single lesion in the left subcortical region and 32 healthy controls (HCs) were recruited in this study. The DTI-ALPS index and DTI metrics (fractional anisotropy, FA, and mean diffusivity, MD) were compared within and between groups. Spearman's and Pearson's partial correlation analyses were performed to analyze the relationships of the DTI-ALPS index with Fugl-Meyer assessment (FMA) scores and with corticospinal tract (CST) integrity in the IS group, respectively.
Results: Six IS patients and two HCs were excluded. The left DTI-ALPS index of the IS group was significantly lower than that of the HC group ( = -3.02, = 0.004). In the IS group, a positive correlation between the left DTI-ALPS index and the simple Fugl-Meyer motor function score (ρ = 0.52, = 0.019) and a significant negative correlation between the left DTI-ALPS index and the FA ( = -0.55, = 0.023) and MD ( = -0.48, = 0.032) values of the right CST were found.
Conclusions: Glymphatic dysfunction is involved in subacute IS. DTI-ALPS could be a potential magnetic resonance (MR) biomarker of motor dysfunction in subacute IS patients. These findings contribute to a better understanding of the pathophysiological mechanisms of IS and provide a new target for alternative treatments for IS.

Keywords

analysis along perivascular space corticospinal tract glymphatic system ischemic stroke motor dysfunction

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Journal Article

Word Cloud

Created with Highcharts 10.0.0IS=dysfunctionDTI-ALPSsubacuteindexmotorpatients0glymphaticleftgroupischemicstrokecorrelationinvolvedactivityanalysisalongperivascularspacestudyHCsFAMDFugl-MeyercorticospinaltractCST-0MRbiomarkerPurpose:BrainpathologicprocessacuterelationshipbrainfullyelucidatedDiffusiontensorimageusedexplorewhetherrelatedMethods:Twenty-sixsinglelesionsubcorticalregion32healthycontrolsrecruitedDTImetricsfractionalanisotropymeandiffusivitycomparedwithingroupsSpearman'sPearson'spartialanalysesperformedanalyzerelationshipsassessmentFMAscoresintegrityrespectivelyResults:SixtwoexcludedsignificantlylowerHC-302004positivesimplefunctionscoreρ52019significantnegative5502348032valuesrightfoundConclusions:GlymphaticpotentialmagneticresonancefindingscontributebetterunderstandingpathophysiologicalmechanismsprovidenewtargetalternativetreatmentsDTI-ALPS:system

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