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Cell stem cell
05 04, 2023;30 (5): 512-529.

Advancing cell therapy for neurodegenerative diseases.

Sally Temple
Author Information
  1. Sally Temple: Neural Stem Cell Institute, Rensselaer, NY 12144, USA. Electronic address: sallytemple@neuralsci.org.
PMID: 37084729 DOI: 10.1016/j.stem.2023.03.017

Abstract

Cell-based therapies are being developed for various neurodegenerative diseases that affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in neurodegenerative pathology are being uncovered by genetic and single-cell studies. With a greater understanding of cellular contributions to health and disease and with the arrival of promising approaches to modulate them, effective therapeutic cell products are now emerging. This review examines how the ability to generate diverse CNS cell types from stem cells, along with a deeper understanding of cell-type-specific functions and pathology, is advancing preclinical development of cell products for the treatment of neurodegenerative diseases.

Keywords

Alzheimer disease GABAergic neurons Parkinson disease age-related macular degeneration astrocytes central nervous system dopaminergic neurons frontotemporal dementia microglia neurodegenerative disease neurons oligodendrocytes organoids photoreceptors preclinical studies progressive supranuclear palsy retina retinal pigment epithelium stem cell therapy transplantation

References

  1. J Neurosci Res. 1993 Jan;34(1):1-13 [PMID: 7678656]
  2. Nat Med. 2022 Mar;28(3):517-527 [PMID: 35190726]
  3. Acta Neuropathol. 2010 Jan;119(1):7-35 [PMID: 20012068]
  4. Nat Commun. 2016 Jun 07;7:11758 [PMID: 27273432]
  5. Mol Ther Methods Clin Dev. 2022 May 31;26:84-94 [PMID: 35795779]
  6. Proc Natl Acad Sci U S A. 2022 May 10;119(19):e2117553119 [PMID: 35522714]
  7. Stem Cells. 2020 Nov;38(11):1375-1386 [PMID: 32638460]
  8. Nat Genet. 2022 Apr;54(4):412-436 [PMID: 35379992]
  9. Hum Mol Genet. 2021 Jul 28;30(16):1543-1558 [PMID: 34014299]
  10. Cell Stem Cell. 2021 Feb 4;28(2):343-355.e5 [PMID: 33545081]
  11. Mol Neurodegener. 2021 Sep 25;16(1):68 [PMID: 34563212]
  12. Brain Pathol. 2007 Jan;17(1):74-82 [PMID: 17493041]
  13. Stem Cell Reports. 2022 Aug 9;17(8):1824-1841 [PMID: 35905738]
  14. Nature. 2022 Mar;603(7903):893-899 [PMID: 35158371]
  15. Stem Cell Reports. 2022 Dec 13;17(12):2690-2703 [PMID: 36368332]
  16. Nat Biotechnol. 2016 Apr;34(4):393-400 [PMID: 27054995]
  17. Cells. 2019 Mar 11;8(3): [PMID: 30862089]
  18. Cell Rep. 2017 Feb 21;18(8):2058-2072 [PMID: 28228269]
  19. Graefes Arch Clin Exp Ophthalmol. 1993 Nov;231(11):635-41 [PMID: 8258397]
  20. Ann Transl Med. 2021 Feb;9(3):245 [PMID: 33708872]
  21. Nat Biotechnol. 2015 Feb;33(2):204-9 [PMID: 25580598]
  22. Mol Neurodegener. 2019 Dec 19;14(1):46 [PMID: 31856864]
  23. Nat Methods. 2019 Jan;16(1):75-78 [PMID: 30573846]
  24. Curr Opin Neurobiol. 2023 Apr;79:102672 [PMID: 36634408]
  25. Cells. 2019 Oct 22;8(10): [PMID: 31652490]
  26. Annu Rev Vis Sci. 2020 Sep 15;6:195-213 [PMID: 32936739]
  27. Mov Disord. 2021 Aug;36(8):1772-1780 [PMID: 33963552]
  28. Int J Mol Sci. 2022 Jun 06;23(11): [PMID: 35683020]
  29. Nat Rev Neurol. 2021 Jun;17(6):333-348 [PMID: 33927394]
  30. Nat Med. 2022 Sep;28(9):1813-1822 [PMID: 36064599]
  31. Front Cell Dev Biol. 2021 May 13;9:666675 [PMID: 34055800]
  32. J Clin Invest. 2022 Jul 15;132(14): [PMID: 35700056]
  33. Nat Commun. 2020 Jul 15;11(1):3630 [PMID: 32669619]
  34. Nat Med. 2006 Nov;12(11):1259-68 [PMID: 17057709]
  35. Nat Genet. 2022 Jan;54(1):4-17 [PMID: 34992268]
  36. Cell. 2021 Sep 2;184(18):4651-4668.e25 [PMID: 34450028]
  37. STAR Protoc. 2021 Oct 20;2(4):100902 [PMID: 34746863]
  38. Semin Ophthalmol. 2011 May;26(3):181-91 [PMID: 21609231]
  39. Acta Neuropathol Commun. 2020 Feb 18;8(1):19 [PMID: 32070434]
  40. Nature. 2017 Jan 26;541(7638):481-487 [PMID: 28099414]
  41. Neuron. 2015 Mar 4;85(5):982-97 [PMID: 25741724]
  42. J Exp Med. 2023 Jan 2;220(1): [PMID: 36399126]
  43. Methods Mol Biol. 2021;2311:73-108 [PMID: 34033079]
  44. Restor Neurol Neurosci. 2020;38(2):131-140 [PMID: 31815704]
  45. Curr Opin Neurobiol. 2019 Jun;56:194-198 [PMID: 31051421]
  46. Front Cell Dev Biol. 2021 May 14;9:663854 [PMID: 34055795]
  47. Cell Stem Cell. 2014 Nov 6;15(5):559-73 [PMID: 25517465]
  48. Stem Cell Reports. 2018 Sep 11;11(3):665-680 [PMID: 30100409]
  49. Front Neurosci. 2020 Jun 30;14:660 [PMID: 32714136]
  50. Nat Biotechnol. 2018 Apr;36(4):328-337 [PMID: 29553577]
  51. Front Oncol. 2022 May 13;12:885639 [PMID: 35646708]
  52. J Exp Med. 2023 Dec 4;220(12): [PMID: 37728563]
  53. Nature. 2012 May 3;485(7396):99-103 [PMID: 22522934]
  54. Cell Stem Cell. 2017 Nov 2;21(5):569-573 [PMID: 29100010]
  55. EClinicalMedicine. 2022 Jul 22;51:101580 [PMID: 35898316]
  56. Stem Cell Reports. 2022 Jul 12;17(7):1636-1649 [PMID: 35714595]
  57. Cell. 2022 Jun 23;185(13):2213-2233.e25 [PMID: 35750033]
  58. Schizophr Res. 2022 May;243:154-162 [PMID: 35344853]
  59. Hum Mol Genet. 2014 Nov 1;23(21):5838-46 [PMID: 24899047]
  60. Nature. 2021 Nov;599(7883):102-107 [PMID: 34616039]
  61. Nat Commun. 2020 Jul 6;11(1):3369 [PMID: 32632153]
  62. Nat Neurosci. 2022 Sep;25(9):1149-1162 [PMID: 35953545]
  63. Neuron. 2022 Nov 2;110(21):3513-3533 [PMID: 36327897]
  64. Stem Cell Res Ther. 2015 May 14;6:93 [PMID: 25971252]
  65. Transl Psychiatry. 2022 Dec 3;12(1):500 [PMID: 36463316]
  66. J Cell Mol Med. 2022 Jun;26(11):3183-3195 [PMID: 35543222]
  67. Stem Cell Reports. 2022 Nov 8;17(11):2392-2408 [PMID: 36306783]
  68. Pediatrics. 2021 Sep;148(3): [PMID: 34426533]
  69. J Neurochem. 2020 Jun;153(6):759-771 [PMID: 31883380]
  70. Cell Rep. 2017 Jan 10;18(2):391-405 [PMID: 28076784]
  71. Sci Transl Med. 2019 Jan 16;11(475): [PMID: 30651323]
  72. Cells. 2022 Oct 15;11(20): [PMID: 36291110]
  73. J Clin Invest. 2022 Nov 15;132(22): [PMID: 36136587]
  74. Acta Neuropathol. 2022 Feb;143(2):143-157 [PMID: 34860266]
  75. Nat Commun. 2018 Dec 6;9(1):5206 [PMID: 30523248]
  76. Front Cell Dev Biol. 2022 Aug 08;10:902261 [PMID: 36003149]
  77. Proc Natl Acad Sci U S A. 2020 Aug 11;117(32):19287-19298 [PMID: 32723825]
  78. J Transl Med. 2023 Feb 28;21(1):161 [PMID: 36855199]
  79. Stem Cell Reports. 2021 Feb 9;16(2):237-251 [PMID: 33450191]
  80. Stem Cell Res Ther. 2013 Aug 29;4(4):102 [PMID: 23987648]
  81. Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):E81-90 [PMID: 26699487]
  82. Cell. 2021 Aug 19;184(17):4547-4563.e17 [PMID: 34314701]
  83. Curr Protoc. 2021 Mar;1(3):e88 [PMID: 33725407]
  84. Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):1101-6 [PMID: 23288902]
  85. Mol Neurodegener. 2018 Dec 22;13(1):67 [PMID: 30577865]
  86. Dev Neurobiol. 2022 Jan;82(1):125-137 [PMID: 34874625]
  87. Cell Stem Cell. 2017 Aug 3;21(2):195-208.e6 [PMID: 28736215]
  88. Cell Stem Cell. 2013 Mar 7;12(3):342-53 [PMID: 23472873]
  89. Nat Commun. 2022 Jul 26;13(1):4233 [PMID: 35882847]
  90. Cell Stem Cell. 2013 Feb 7;12(2):252-64 [PMID: 23395447]
  91. J Exp Med. 2023 Mar 6;220(3): [PMID: 36584406]
  92. Neurotherapeutics. 2023 Jan;20(1):39-47 [PMID: 36357662]
  93. Nat Neurosci. 2019 Dec;22(12):2111-2116 [PMID: 31659342]
  94. Nat Biotechnol. 2019 Oct;37(10):1137-1144 [PMID: 31427818]
  95. Neuron. 2017 Apr 19;94(2):278-293.e9 [PMID: 28426964]
  96. Nature. 2019 Feb;566(7745):543-547 [PMID: 30747918]
  97. Nat Commun. 2015 Mar 25;6:6626 [PMID: 25806427]
  98. Brain Res Bull. 2023 Mar;194:64-81 [PMID: 36690163]
  99. Nat Biotechnol. 2019 Mar;37(3):267-275 [PMID: 30804533]
  100. Front Mol Neurosci. 2021 Jul 08;14:699562 [PMID: 34305528]
  101. Elife. 2018 Sep 25;7: [PMID: 30251953]
  102. Stem Cell Res Ther. 2018 Jun 6;9(1):152 [PMID: 29871694]
  103. EMBO Rep. 2017 Jul;18(7):1186-1198 [PMID: 28483841]
  104. Stem Cell Reports. 2019 Feb 12;12(2):191-200 [PMID: 30661995]
  105. Nature. 2017 Aug 30;548(7669):592-596 [PMID: 28858313]
  106. Nat Biotechnol. 2011 May 22;29(6):528-34 [PMID: 21602806]
  107. Retina. 2001;21(4):293-303 [PMID: 11508873]
  108. Lancet Public Health. 2022 Feb;7(2):e105-e125 [PMID: 34998485]
  109. Sci Rep. 2020 Oct 15;10(1):17359 [PMID: 33060618]
  110. Mol Ther. 2017 Mar 1;25(3):634-653 [PMID: 28143742]
  111. Stem Cell Reports. 2018 Apr 10;10(4):1282-1293 [PMID: 29576537]
  112. Nat Commun. 2021 Mar 12;12(1):1610 [PMID: 33712570]
  113. Neurotherapeutics. 2020 Jul;17(3):874-885 [PMID: 33029722]
  114. J Ocul Pharmacol Ther. 2016 Jun;32(5):317-30 [PMID: 27182743]
  115. Front Cell Dev Biol. 2022 Aug 12;10:956279 [PMID: 36035999]
  116. Cell Rep. 2022 Jun 14;39(11):110961 [PMID: 35705056]
  117. NPJ Regen Med. 2022 Apr 21;7(1):24 [PMID: 35449132]
  118. Ophthalmic Res. 2012;48(4):186-91 [PMID: 22868580]
  119. Nature. 2011 Nov 06;480(7378):547-51 [PMID: 22056989]
  120. Cell Stem Cell. 2021 Feb 4;28(2):217-229.e7 [PMID: 33545080]
  121. Ophthalmic Surg Lasers Imaging Retina. 2016 Apr 1;47(4):342-51 [PMID: 27065374]
  122. Cell Stem Cell. 2015 Feb 5;16(2):198-210 [PMID: 25658373]
  123. Nat Commun. 2020 Oct 15;11(1):5196 [PMID: 33060592]
  124. Development. 2019 Jan 9;146(1): [PMID: 30567931]
  125. Elife. 2022 May 04;11: [PMID: 35506651]
  126. Cell Transplant. 2022 Jan-Dec;31:9636897221105499 [PMID: 35770772]
  127. Nat Rev Neurol. 2017 Apr;13(4):232-243 [PMID: 28303913]
  128. Nat Neurosci. 2022 May;25(5):588-595 [PMID: 35513515]
  129. Regen Med. 2019 May;14(4):295-307 [PMID: 31074319]
  130. Nature. 2022 Mar;603(7903):885-892 [PMID: 35165441]
  131. Neuron. 2022 Nov 2;110(21):3458-3483 [PMID: 36327895]
  132. Stem Cell Reports. 2018 Jan 9;10(1):58-72 [PMID: 29233555]
  133. Mol Neurodegener. 2019 Aug 16;14(1):34 [PMID: 31419995]
  134. Science. 2017 Jun 23;356(6344): [PMID: 28546318]
  135. Nature. 2022 Jan;601(7893):397-403 [PMID: 34912114]
  136. Front Genet. 2022 May 04;13:686739 [PMID: 35601482]
  137. Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):E2243-E2252 [PMID: 28246330]
  138. Stem Cells Transl Med. 2015 Oct;4(10):1155-63 [PMID: 26315572]
  139. Methods Mol Biol. 2022;2375:1-12 [PMID: 34591294]
  140. Nat Commun. 2016 Oct 04;7:13028 [PMID: 27701381]
  141. Nat Commun. 2018 Jul 17;9(1):2759 [PMID: 30018341]
  142. Sci Transl Med. 2019 Aug 14;11(505): [PMID: 31413141]
  143. Neuron. 2020 Aug 5;107(3):436-453.e12 [PMID: 32485136]
  144. Hum Mol Genet. 2014 Jan 15;23(2):342-54 [PMID: 24006477]
  145. Stem Cell Reports. 2022 Jan 11;17(1):14-34 [PMID: 34971564]
  146. Cell Stem Cell. 2013 May 2;12(5):573-86 [PMID: 23642366]
  147. Mol Diagn Ther. 2021 Nov;25(6):803-809 [PMID: 34424497]
  148. Cell Stem Cell. 2020 Oct 1;27(4):523-531 [PMID: 33007237]
  149. Semin Cell Dev Biol. 2021 Aug;116:62-70 [PMID: 33414060]
  150. N Engl J Med. 2020 May 14;382(20):1926-1932 [PMID: 32402162]
  151. Nat Biotechnol. 2019 Mar;37(3):252-258 [PMID: 30778232]
  152. Trends Immunol. 2020 Sep;41(9):758-770 [PMID: 32819810]
  153. Nat Neurosci. 2022 May;25(5):659-674 [PMID: 35524141]
  154. Sci Transl Med. 2022 Mar 16;14(636):eabl9945 [PMID: 35294256]
  155. Glia. 2020 Apr;68(4):685-704 [PMID: 31926040]
  156. Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):7089-7094 [PMID: 30894491]
  157. Methods Cell Biol. 2020;159:279-302 [PMID: 32586447]
  158. Stem Cells Dev. 2018 Jul 15;27(14):958-959 [PMID: 29790422]
  159. Nat Med. 2020 Jun;26(6):952-963 [PMID: 32514169]
  160. EJNMMI Res. 2017 Dec;7(1):59 [PMID: 28741281]
  161. Nat Protoc. 2014;9(6):1514-31 [PMID: 24874816]
  162. Stem Cell Reports. 2017 Aug 8;9(2):600-614 [PMID: 28757165]
  163. Stem Cell Reports. 2023 Aug 8;18(8):1599-1609 [PMID: 36563687]
  164. Cell Tissue Res. 2020 Dec;382(3):463-476 [PMID: 32737576]
  165. Stem Cell Reports. 2020 Aug 11;15(2):467-481 [PMID: 32679062]
  166. J Mov Disord. 2023 Jan;16(1):22-41 [PMID: 36628428]
  167. Cell Stem Cell. 2008 Jun 5;2(6):553-65 [PMID: 18522848]
  168. Arterioscler Thromb Vasc Biol. 2019 Jul;39(7):1317-1329 [PMID: 31242035]
  169. J Clin Invest. 2012 Aug;122(8):2928-39 [PMID: 22751106]
  170. Elife. 2020 Jul 07;9: [PMID: 32633719]
  171. Nat Neurosci. 2021 Mar;24(3):312-325 [PMID: 33589835]
  172. Proc Natl Acad Sci U S A. 2021 Feb 23;118(8): [PMID: 33542154]
  173. EMBO Mol Med. 2018 Dec;10(12): [PMID: 30482868]
  174. Neuro Oncol. 2016 Apr;18(4):557-64 [PMID: 26449250]
  175. Nat Commun. 2016 Oct 04;7:13029 [PMID: 27701378]
  176. Stem Cells. 2021 Aug;39(8):1017-1024 [PMID: 33754425]
  177. Nat Neurosci. 2021 Dec;24(12):1745-1756 [PMID: 34737447]
  178. Nat Neurosci. 2007 May;10(5):615-22 [PMID: 17435755]
  179. Dev Neurobiol. 2010 Oct;70(12):826-41 [PMID: 20629049]
  180. Neuron. 2019 Sep 25;103(6):1016-1033.e10 [PMID: 31375314]
  181. Transl Vis Sci Technol. 2021 Aug 12;10(10):9 [PMID: 34383873]
  182. Nat Commun. 2020 Oct 23;11(1):5370 [PMID: 33097708]
  183. Acta Neuropathol. 2022 Oct;144(4):603-614 [PMID: 35947184]
  184. Sci Transl Med. 2010 Jun 30;2(38):38ra46 [PMID: 20592420]
  185. Sci Data. 2021 Feb 2;8(1):39 [PMID: 33531477]
  186. Nat Med. 2008 May;14(5):504-6 [PMID: 18391962]
  187. Stem Cell Reports. 2021 Aug 10;16(8):1923-1937 [PMID: 34297942]
  188. Front Neurosci. 2021 Oct 26;15:752958 [PMID: 34764853]
  189. Front Neurosci. 2019 Jun 28;13:669 [PMID: 31316341]
  190. Cells. 2021 Aug 07;10(8): [PMID: 34440788]
  191. Nat Med. 2016 Nov;22(11):1358-1367 [PMID: 27668937]
  192. Nat Genet. 2011 Dec 25;44(2):200-5 [PMID: 22197934]
  193. Front Cell Dev Biol. 2021 Jul 09;9:696434 [PMID: 34307372]
  194. Alzheimers Dement. 2017 Apr;13(4):381-387 [PMID: 27520774]
  195. Stem Cell Res. 2022 Mar;59:102642 [PMID: 34971934]
  196. EBioMedicine. 2019 Jan;39:562-574 [PMID: 30502055]
  197. Cell Rep. 2020 Nov 17;33(7):108398 [PMID: 33207193]
  198. Development. 2001 Apr;128(7):1059-68 [PMID: 11245571]
  199. Stem Cells. 2018 Jul;36(7):1122-1131 [PMID: 29656478]
  200. Cell Stem Cell. 2017 Jan 5;20(1):135-148 [PMID: 28094017]
  201. Stem Cell Reports. 2014 Apr 24;2(5):662-74 [PMID: 24936453]
  202. J Clin Med. 2019 May 10;8(5): [PMID: 31083442]
  203. Curr Opin Neurobiol. 2021 Feb;66:195-204 [PMID: 33412482]
  204. Front Immunol. 2022 Feb 01;12:813957 [PMID: 35178046]
  205. Stem Cell Reports. 2022 Mar 8;17(3):448-458 [PMID: 35120620]
  206. Stem Cell Reports. 2020 Mar 10;14(3):406-419 [PMID: 32109367]
  207. Stem Cell Reports. 2017 Sep 12;9(3):820-837 [PMID: 28844659]
  208. Front Cardiovasc Med. 2020 Mar 31;7:42 [PMID: 32296715]
  209. Front Cell Dev Biol. 2022 Mar 16;10:851613 [PMID: 35372346]
  210. Cells. 2022 Oct 30;11(21): [PMID: 36359825]
  211. Trends Immunol. 2020 Sep;41(9):771-784 [PMID: 32792173]
  212. Graefes Arch Clin Exp Ophthalmol. 1999 Apr;237(4):313-25 [PMID: 10208265]
  213. Nat Commun. 2022 Dec 26;13(1):7945 [PMID: 36572698]
  214. Cell Rep. 2020 May 19;31(7):107658 [PMID: 32433967]
  215. Cell Stem Cell. 2013 May 2;12(5):559-72 [PMID: 23642365]
  216. Hum Gene Ther. 2005 Apr;16(4):509-21 [PMID: 15871682]
  217. Glia. 2019 Oct;67(10):1797-1805 [PMID: 30968471]
  218. Cell Prolif. 2021 Aug;54(8):e13082 [PMID: 34152047]
  219. Brain. 2015 Jun;138(Pt 6):1738-55 [PMID: 25833819]
  220. Front Cell Dev Biol. 2021 Dec 17;9:802457 [PMID: 34977041]
  221. Cell Rep. 2020 Jun 9;31(10):107732 [PMID: 32521257]
  222. Stem Cells. 2018 Dec;36(12):1816-1827 [PMID: 30171748]
  223. Proc Natl Acad Sci U S A. 2020 Oct 13;117(41):25800-25809 [PMID: 32989152]
  224. Stem Cell Reports. 2017 Jul 11;9(1):42-49 [PMID: 28625537]
  225. Nat Neurosci. 2018 Oct;21(10):1318-1331 [PMID: 30250261]
  226. Stem Cell Reports. 2018 Oct 9;11(4):998-1008 [PMID: 30269954]
  227. Int J Mol Sci. 2022 Jan 08;23(2): [PMID: 35054869]
  228. Nat Commun. 2020 May 15;11(1):2434 [PMID: 32415072]
  229. Cells. 2021 Jun 01;10(6): [PMID: 34206038]
  230. Science. 2014 Apr 11;344(6180):1240622 [PMID: 24723614]
  231. Nat Biotechnol. 2018 Jun;36(5):432-441 [PMID: 29658944]
  232. Commun Biol. 2021 Jun 25;4(1):798 [PMID: 34172826]
  233. Neuron. 2023 Mar 15;111(6):807-823.e7 [PMID: 36626901]
  234. Brain. 2020 Dec 5;143(11):3449-3462 [PMID: 33141154]
  235. Biomaterials. 2020 Feb;230:119603 [PMID: 31732225]
  236. Brain Res. 2021 May 1;1758:147291 [PMID: 33516810]
  237. Stem Cells Transl Med. 2022 Dec 30;11(12):1196-1209 [PMID: 36181767]
  238. Stem Cells Transl Med. 2021 Feb;10(2):198-208 [PMID: 32946199]
  239. Invest Ophthalmol Vis Sci. 2016 Apr 1;57(5):ORSFc1-9 [PMID: 27116660]
  240. Asia Pac J Ophthalmol (Phila). 2022 Jul-Aug 01;11(4):314-327 [PMID: 36041146]
  241. Glia. 2021 Mar;69(3):513-531 [PMID: 33052610]
  242. Nature. 2022 Oct;610(7931):319-326 [PMID: 36224417]
  243. Nat Med. 2022 Jun;28(6):1149-1156 [PMID: 35715505]
  244. Stem Cell Reports. 2016 Jan 12;6(1):1-8 [PMID: 26724902]

Grants

  1. R01 EY032138/NEI NIH HHS
  2. R35 NS097277/NINDS NIH HHS
  3. RF1 NS123568/NINDS NIH HHS
  4. U01 AG072464/NIA NIH HHS

MeSH Term

Humans
Neurodegenerative Diseases
Central Nervous System
Stem Cells
Cell- and Tissue-Based Therapy
Journal Article Review Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't
Article has an altmetric score of 34

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