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BMJ open
04 21, 2023;13 (4): e062491.

Acupuncture for protracted amphetamine abstinence syndrome: study protocol for a systematic review and meta-analysis.

Su Zhang, Jun Luo, YiWei Zeng, Huan Ren, Zhihan Chen, Yulan Ren
Author Information
  1. Su Zhang: School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China. ORCID
  2. Jun Luo: School of Chinese Classics, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  3. YiWei Zeng: School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China. ORCID
  4. Huan Ren: School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
  5. Zhihan Chen: School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China. ORCID
  6. Yulan Ren: School of Chinese Classics, Chengdu University of Traditional Chinese Medicine, Chengdu, China renxg2468@163.com.
PMID: 37085314 DOI: 10.1136/bmjopen-2022-062491

Abstract

INTRODUCTION: Amphetamine-type stimulants (ATSs) are presenting a great challenge to global public health along with its worldwide abuse in recent years. Protracted amphetamine abstinence syndrome (PAAS) is one of the primary causes of relapse for ATS abusers during withdrawal. However, different conclusions are reached by previous trials. This study is designed to evaluate the efficacy and safety of acupuncture in treating PAAS.
METHODS AND ANALYSIS: Cochrane Central Register of Controlled Trials, PubMed, Embase, Web of Science, Cumulative Index to Nursing and Allied Health Literature (CINAHL), PsycINFO, ProQuest Dissertation and Theses, Allied and Complementary Medicine Database (AMED), ClinicalTrials.gov and who.int/trialsearch will be searched from the inception to February 2023 and language will be restricted to English and Chinese. Eligible randomised controlled trials will be included. The primary outcome is the intensity of withdrawal syndrome. The secondary outcomes include: (1) intensity of pain, anxiety, depression and other associated symptoms; (2) number of participants with relapse; (3) retention of treatment and (4) nature and rate of adverse effects. Data synthesis will be performed by using RevMan (V.5.4). The quality of evidence will be evaluated by the Grading of Recommendations, Assessment, Development and Evaluation approach. This study will strictly adhere to the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines.
ETHICS AND DISSEMINATION: Ethical approval is not required as this is a systematic review and meta-analysis based on previously published studies that do not involve patients' privacy. The results of this study will be disseminated in a peer-reviewed journal.
PROSPERO REGISTRATION NUMBER: CRD42022297761.

Keywords

complementary medicine psychiatry substance misuse

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MeSH Term

Humans
Amphetamine
Neoplasm Recurrence, Local
Systematic Reviews as Topic
Meta-Analysis as Topic
Acupuncture Therapy
Chronic Disease
Research Design

Chemicals

Amphetamine
Journal Article Research Support, Non-U.S. Gov't

Word Cloud

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