OpenLB
Open Library of Bioscience
Advanced Search
Frontiers in cellular and infection microbiology
2023;13 1119037.

A new approach to overcoming antibiotic-resistant bacteria: Traditional Chinese medicine therapy based on the gut microbiota.

Peng Xue, Rui Sang, Nan Li, Siyuan Du, Xiuwen Kong, Mingliang Tai, Zhihao Jiang, Ying Chen
Author Information
  1. Peng Xue: Medical School of Nantong University, Nantong, Jiangsu, China.
  2. Rui Sang: Center for Basic Medical Research, Medical School of Nantong University, Nantong, Jiangsu, China.
  3. Nan Li: Department of Histology and Embryology, Medical College, Nantong University, Nantong, Jiangsu, China.
  4. Siyuan Du: Medical School of Nantong University, Nantong, Jiangsu, China.
  5. Xiuwen Kong: Medical School of Nantong University, Nantong, Jiangsu, China.
  6. Mingliang Tai: Medical School of Nantong University, Nantong, Jiangsu, China.
  7. Zhihao Jiang: Center for Basic Medical Research, Medical School of Nantong University, Nantong, Jiangsu, China.
  8. Ying Chen: Department of Histology and Embryology, Medical College, Nantong University, Nantong, Jiangsu, China.
PMID: 37091671 DOI: 10.3389/fcimb.2023.1119037

Abstract

With the irrational use of antibiotics and the increasing abuse of oral antibiotics, the drug resistance of gastrointestinal pathogens has become a prominent problem in clinical practice. Gut microbiota plays an important role in maintaining human health, and the change of microbiota also affects the activity of pathogenic bacteria. Interfering with antibiotic resistant bacteria by affecting gut microbiota has also become an important regulatory signal. In clinical application, due to the unique advantages of traditional Chinese medicine in sterilization and drug resistance, it is possible for traditional Chinese medicine to improve the gut microbial microenvironment. This review discusses the strategies of traditional Chinese medicine for the treatment of drug-resistant bacterial infections by changing the gut microenvironment, unlocking the interaction between microbiota and drug resistance of pathogenic bacteria.

Keywords

drug-resistant bacteria gut microbiota multi-drug resistance reversion mechanism traditional Chinese medicine

References

  1. Diagn Microbiol Infect Dis. 2018 Nov;92(3):262-266 [PMID: 30098852]
  2. Eur J Pharmacol. 2020 Sep 5;882:173267 [PMID: 32569674]
  3. Nat Rev Gastroenterol Hepatol. 2017 Apr;14(4):230-240 [PMID: 28053340]
  4. Viruses. 2019 Jan 24;11(2): [PMID: 30678377]
  5. Zhong Yao Cai. 2008 May;31(5):707-10 [PMID: 18826148]
  6. Antimicrob Agents Chemother. 2000 Jul;44(7):1771-7 [PMID: 10858329]
  7. Antimicrob Agents Chemother. 2016 Dec 27;61(1): [PMID: 27821450]
  8. Front Cell Infect Microbiol. 2017 Mar 13;7:55 [PMID: 28348979]
  9. PLoS One. 2015 Mar 17;10(3):e0119564 [PMID: 25781975]
  10. J Glob Antimicrob Resist. 2020 Sep;22:620-624 [PMID: 32590188]
  11. Microb Pathog. 2021 Jan;150:104676 [PMID: 33278518]
  12. Sci Rep. 2021 Nov 5;11(1):21726 [PMID: 34741111]
  13. FEMS Microbiol Ecol. 2014 Jul;89(1):1-14 [PMID: 24754832]
  14. Microb Pathog. 2022 Dec;173(Pt A):105824 [PMID: 36243382]
  15. Toxins (Basel). 2021 Nov 15;13(11): [PMID: 34822588]
  16. Food Chem Toxicol. 2019 Mar;125:322-332 [PMID: 30654101]
  17. Curr Opin Microbiol. 2020 Feb;53:35-43 [PMID: 32143027]
  18. Exp Biol Med (Maywood). 2017 Apr;242(7):731-743 [PMID: 28118725]
  19. Microbiol Immunol. 2005;49(4):391-6 [PMID: 15840965]
  20. World J Gastroenterol. 2015 Apr 14;21(14):4225-31 [PMID: 25892872]
  21. J Infect Dis. 2021 Jun 16;223(12 Suppl 2):S209-S213 [PMID: 33326581]
  22. J Appl Microbiol. 2013 May;114(5):1294-9 [PMID: 23414263]
  23. Nature. 2019 Sep;573(7773):276-280 [PMID: 31485077]
  24. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17025-30 [PMID: 12482953]
  25. Phytomedicine. 2021 May;85:153279 [PMID: 32675044]
  26. Microb Drug Resist. 2021 Jan;27(1):13-17 [PMID: 32522082]
  27. Helicobacter. 2018 Apr;23(2):e12475 [PMID: 29512258]
  28. Int J Med Microbiol. 2015 Sep;305(6):501-4 [PMID: 26028441]
  29. Pol J Microbiol. 2014;63(2):137-45 [PMID: 25115107]
  30. Antibiotics (Basel). 2021 Jul 17;10(7): [PMID: 34356792]
  31. Chem Rev. 2021 Mar 24;121(6):3390-3411 [PMID: 32441527]
  32. Drugs. 2009 Aug 20;69(12):1555-623 [PMID: 19678712]
  33. Nat Prod Res. 2021 Nov;35(22):4643-4647 [PMID: 34798693]
  34. Small. 2008 Jan;4(1):26-49 [PMID: 18165959]
  35. J Pharm Pharmacol. 2015 Jan;67(1):107-16 [PMID: 25212982]
  36. J Agric Food Chem. 2019 Sep 11;67(36):10222-10234 [PMID: 31385700]
  37. J Ethnopharmacol. 2011 Apr 12;134(3):1006-9 [PMID: 21296143]
  38. Emerg Infect Dis. 2004 Mar;10(3):514-7 [PMID: 15109426]
  39. J Bioenerg Biomembr. 2021 Aug;53(4):489-498 [PMID: 34159523]
  40. Cell Host Microbe. 2019 Feb 13;25(2):219-232 [PMID: 30763536]
  41. Antimicrob Agents Chemother. 2004 May;48(5):1848-55 [PMID: 15105143]
  42. Int J Antimicrob Agents. 2017 Feb;49(2):137-152 [PMID: 28089172]
  43. Int J Antimicrob Agents. 2019 Jan;53(1):70-73 [PMID: 30176356]
  44. J Cell Mol Med. 2020 Aug;24(15):8763-8771 [PMID: 32588543]
  45. Int J Nanomedicine. 2019 Feb 25;14:1469-1487 [PMID: 30880959]
  46. mSystems. 2018 Jun 26;3(3): [PMID: 29963640]
  47. J Microbiol. 2017 Oct;55(10):753-766 [PMID: 28956348]
  48. J Pharm Pharmacol. 2007 Nov;59(11):1567-72 [PMID: 17976269]
  49. Molecules. 2022 Aug 08;27(15): [PMID: 35956993]
  50. Curr Microbiol. 2022 Apr 9;79(5):149 [PMID: 35397072]
  51. Clin Ther. 2020 Sep;42(9):1637-1648 [PMID: 32800382]
  52. J Bacteriol. 1984 May;158(2):513-6 [PMID: 6563036]
  53. Nature. 2016 Jul 06;535(7610):85-93 [PMID: 27383983]
  54. Gut Microbes. 2022 Jan-Dec;14(1):2113717 [PMID: 36037202]
  55. J Ethnopharmacol. 2021 May 10;271:113895 [PMID: 33524512]
  56. Infect Disord Drug Targets. 2021;21(7):e160921191517 [PMID: 33596813]
  57. J Nanobiotechnology. 2014 Jan 14;12:2 [PMID: 24422704]
  58. Med Sci (Paris). 2008 May;24(5):449-51 [PMID: 18466714]
  59. Front Microbiol. 2022 Sep 06;13:962354 [PMID: 36147839]
  60. Front Public Health. 2014 Sep 16;2:145 [PMID: 25279369]
  61. Microbiol Spectr. 2018 Jul;6(4): [PMID: 30003866]
  62. BMC Microbiol. 2022 Feb 3;22(1):41 [PMID: 35114945]
  63. Expert Opin Pharmacother. 2023 Feb;24(3):331-346 [PMID: 36548447]
  64. J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Feb 15;1165:122524 [PMID: 33486218]
  65. Nat Rev Microbiol. 2014 Jan;12(1):35-48 [PMID: 24336183]
  66. Microorganisms. 2021 Jan 27;9(2): [PMID: 33513949]
  67. Microbiology (Reading). 2005 Dec;151(Pt 12):3873-3880 [PMID: 16339933]
  68. J Pak Med Assoc. 2022 Mar;72(3):509-515 [PMID: 35320234]
  69. Front Pharmacol. 2022 Jun 02;13:837907 [PMID: 35721131]
  70. Microbiol Spectr. 2016 Apr;4(2): [PMID: 27227291]
  71. Environ Res. 2021 Aug;199:111321 [PMID: 33989619]
  72. Clin Microbiol Infect. 2012 Mar;18(3):E37-45 [PMID: 22264314]
  73. Microb Pathog. 2020 Oct;147:104411 [PMID: 32745664]
  74. Antimicrob Agents Chemother. 2011 Mar;55(3):947-53 [PMID: 21173183]
  75. Exp Ther Med. 2016 Jun;11(6):2597-2601 [PMID: 27284353]
  76. Antimicrob Agents Chemother. 2016 Dec 27;61(1): [PMID: 27821441]
  77. Antimicrob Agents Chemother. 2013 May;57(5):2066-75 [PMID: 23403434]
  78. J Mater Chem B. 2021 Jan 28;9(3):864-875 [PMID: 33392614]
  79. Colloids Surf B Biointerfaces. 2013 Feb 1;102:540-5 [PMID: 23104023]
  80. Sci Rep. 2021 Mar 30;11(1):7134 [PMID: 33785834]
  81. mBio. 2013 Jul 23;4(4): [PMID: 23882013]
  82. Int J Biol Sci. 2021 Aug 18;17(13):3573-3582 [PMID: 34512166]
  83. Front Cell Infect Microbiol. 2019 Feb 18;9:22 [PMID: 30834237]
  84. Phytomedicine. 2022 Nov;106:154421 [PMID: 36054995]
  85. Nat Rev Microbiol. 2009 Apr;7(4):263-73 [PMID: 19287449]
  86. Mater Sci Eng C Mater Biol Appl. 2019 Sep;102:247-253 [PMID: 31146997]
  87. Microbiol Spectr. 2019 Mar;7(2): [PMID: 30900543]
  88. Nat Rev Drug Discov. 2003 Feb;2(2):114-22 [PMID: 12563302]
  89. Front Microbiol. 2020 Dec 22;11:610070 [PMID: 33414777]
  90. Int J Antimicrob Agents. 2020 Feb;55(2):105851 [PMID: 31770624]
  91. Infect Drug Resist. 2015 Jul 24;8:217-30 [PMID: 26244026]
  92. J Phys Chem B. 2018 Feb 1;122(4):1427-1438 [PMID: 29309144]
  93. Biomed Pharmacother. 2017 Sep;93:709-712 [PMID: 28700974]
  94. Infect Immun. 2012 Jan;80(1):62-73 [PMID: 22006564]
  95. Antimicrob Resist Infect Control. 2018 Apr 25;7:58 [PMID: 29713465]
  96. J Antimicrob Chemother. 2015 Mar;70(3):701-9 [PMID: 25433011]
  97. Clin Microbiol Rev. 2019 Aug 28;32(4): [PMID: 31462403]
  98. Molecules. 2015 Jul 28;20(8):13705-24 [PMID: 26225951]
  99. Cell Physiol Biochem. 2011;28(5):1045-50 [PMID: 22178954]
  100. Food Funct. 2022 Oct 3;13(19):9761-9771 [PMID: 36124641]
  101. Int J Antimicrob Agents. 2020 Sep;56(3):106098 [PMID: 32707171]
  102. Ann Med. 2016;48(4):246-55 [PMID: 27092975]
  103. J Hosp Med. 2012 Mar;7(3):243-8 [PMID: 22076962]
  104. Biomed Res Int. 2014;2014:635152 [PMID: 25050369]
  105. Crit Rev Microbiol. 2019 May;45(3):315-333 [PMID: 31012772]
  106. BMC Microbiol. 2020 Oct 19;20(1):317 [PMID: 33076836]
  107. Infect Dis Clin North Am. 2020 Dec;34(4):751-771 [PMID: 33131572]
  108. Pathogens. 2021 Jul 11;10(7): [PMID: 34358027]
  109. Microb Pathog. 2021 Oct;159:105094 [PMID: 34280500]
  110. Antimicrob Agents Chemother. 2007 Jul;51(7):2445-53 [PMID: 17502409]
  111. Evid Based Complement Alternat Med. 2022 Feb 16;2022:1488141 [PMID: 35222666]
  112. Molecules. 2020 Jun 23;25(12): [PMID: 32586045]
  113. Biochem Biophys Res Commun. 2019 Oct 20;518(3):459-464 [PMID: 31443962]
  114. Foodborne Pathog Dis. 2019 Aug;16(8):573-580 [PMID: 30994374]
  115. J Mater Sci Mater Med. 2011 Apr;22(4):789-96 [PMID: 21442192]
  116. Gut. 2016 Apr;65(4):575-83 [PMID: 26511795]
  117. Infect Drug Resist. 2021 Oct 21;14:4363-4374 [PMID: 34707380]

MeSH Term

Humans
Anti-Bacterial Agents
Gastrointestinal Microbiome
Medicine, Chinese Traditional
Bacteria
Microbiota

Chemicals

Anti-Bacterial Agents
Journal Article Review Research Support, Non-U.S. Gov't
Article has an altmetric score of 1

Word Cloud

Similar Articles

Cited By